Effects of a mindfulness-based versus a health self-management intervention on objective cognitive performance in older adults with subjective cognitive decline (SCD): a secondary analysis of the SCD-Well randomized controlled trial.
Cognition
Compassion
Mindfulness
Randomized controlled trial
Subjective cognitive decline
Journal
Alzheimer's research & therapy
ISSN: 1758-9193
Titre abrégé: Alzheimers Res Ther
Pays: England
ID NLM: 101511643
Informations de publication
Date de publication:
06 09 2022
06 09 2022
Historique:
received:
22
12
2021
accepted:
29
07
2022
entrez:
6
9
2022
pubmed:
7
9
2022
medline:
9
9
2022
Statut:
epublish
Résumé
Older individuals with subjective cognitive decline (SCD) perceive that their cognition has declined but do not show objective impairment on neuropsychological tests. Individuals with SCD are at elevated risk of objective cognitive decline and incident dementia. Non-pharmacological interventions (including mindfulness-based and health self-management approaches) are a potential strategy to maintain or improve cognition in SCD, which may ultimately reduce dementia risk. This study utilized data from the SCD-Well randomized controlled trial. One hundred forty-seven older adults with SCD (M Across all cognitive composites, there were no significant time-by-trial arm interactions and no measurable cognitive retest effects; sensitivity analyses supported these results. Improvements, however, were observed within both trial arms on the PACC5 Two non-pharmacological interventions conferred small, non-differing improvements to a global cognitive composite sensitive to amyloid-beta-related decline. There was weaker evidence of an effect on attention, and no evidence of an effect on executive function. Importantly, observed improvements were maintained beyond the end of the interventions. Improving cognition is an important step toward dementia prevention, and future research is needed to delineate the mechanisms of action of these interventions and to utilize clinical endpoints (i.e., progression to mild cognitive impairment or dementia). ClinicalTrials.gov, NCT03005652.
Sections du résumé
BACKGROUND
Older individuals with subjective cognitive decline (SCD) perceive that their cognition has declined but do not show objective impairment on neuropsychological tests. Individuals with SCD are at elevated risk of objective cognitive decline and incident dementia. Non-pharmacological interventions (including mindfulness-based and health self-management approaches) are a potential strategy to maintain or improve cognition in SCD, which may ultimately reduce dementia risk.
METHODS
This study utilized data from the SCD-Well randomized controlled trial. One hundred forty-seven older adults with SCD (M
RESULTS
Across all cognitive composites, there were no significant time-by-trial arm interactions and no measurable cognitive retest effects; sensitivity analyses supported these results. Improvements, however, were observed within both trial arms on the PACC5
CONCLUSIONS
Two non-pharmacological interventions conferred small, non-differing improvements to a global cognitive composite sensitive to amyloid-beta-related decline. There was weaker evidence of an effect on attention, and no evidence of an effect on executive function. Importantly, observed improvements were maintained beyond the end of the interventions. Improving cognition is an important step toward dementia prevention, and future research is needed to delineate the mechanisms of action of these interventions and to utilize clinical endpoints (i.e., progression to mild cognitive impairment or dementia).
TRIAL REGISTRATION
ClinicalTrials.gov, NCT03005652.
Identifiants
pubmed: 36068621
doi: 10.1186/s13195-022-01057-w
pii: 10.1186/s13195-022-01057-w
pmc: PMC9446839
doi:
Banques de données
ClinicalTrials.gov
['NCT03005652']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
125Investigateurs
Amélie Michon
(A)
Raquel Sanchez-Valle
(R)
Claudia Schwars
(C)
Cindy Lai
(C)
Roxane Coueron
(R)
Eider M Arenaza-Urquijo
(EM)
Géraldine Poisnel
(G)
Floriane Delphin-Combe
(F)
Julien Asselineau
(J)
Pierre Krolak-Salmon
(P)
José Luis Molinuevo
(JL)
Florence Allais
(F)
Romain Bachelet
(R)
Viviane Belleoud
(V)
Clara Benson
(C)
Beatriz Bosch
(B)
Maria Pilar Casanova
(MP)
Hélène Espérou
(H)
Karine Goldet
(K)
Idir Hamdidouche
(I)
Maria Leon
(M)
Dix Meiberth
(D)
Hendrik Mueller
(H)
Theresa Mueller
(T)
Valentin Ourry
(V)
Leslie Reyrolle
(L)
Ana Salinero
(A)
Lena Sannemann
(L)
Yamna Satgunasingam
(Y)
Hilde Steinhauser
(H)
Patrik Vuilleumier
(P)
Cédrick Wallet
(C)
Janet Wingrove
(J)
Informations de copyright
© 2022. The Author(s).
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