Characterizing the Contributions of Various Clostridium perfringens Enterotoxin Properties to
Caco-2 cells
Clostridium perfringens
enterotoxemia
enterotoxin
permeability alterations
pore formation
Journal
mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533
Informations de publication
Date de publication:
26 Oct 2022
26 Oct 2022
Historique:
pubmed:
8
9
2022
medline:
29
10
2022
entrez:
7
9
2022
Statut:
ppublish
Résumé
Clostridium perfringens enterotoxin (CPE) is thought to cause lethal enterotoxemia when absorbed from the intestinal lumen into the circulation. CPE action sequentially involves receptor-binding, oligomerization into a prepore, and pore formation. To explore the mechanistic basis by which CPE alters permeability, this study tested the permeability effects of several recombinant CPE (rCPE) species: rCPE and rCPE
Identifiants
pubmed: 36069435
doi: 10.1128/msphere.00276-22
pmc: PMC9599344
doi:
Substances chimiques
enterotoxin, Clostridium
0
Evans Blue
45PG892GO1
Dextrans
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0027622Subventions
Organisme : NIAID NIH HHS
ID : R01 AI019844
Pays : United States
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