Extracellular microRNA and cognitive function in a prospective cohort of older men: The Veterans Affairs Normative Aging Study.
RNA-seq
cognitive decline
cognitive impairment
extracellular RNA
microRNA
plasma
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
06 Sep 2022
06 Sep 2022
Historique:
received:
29
03
2022
accepted:
17
08
2022
pubmed:
8
9
2022
medline:
24
9
2022
entrez:
7
9
2022
Statut:
ppublish
Résumé
Aging-related cognitive decline is an early symptom of Alzheimer's disease and other dementias, and on its own can have substantial consequences on an individual's ability to perform important everyday functions. Despite increasing interest in the potential roles of extracellular microRNAs (miRNAs) in central nervous system (CNS) pathologies, there has been little research on extracellular miRNAs in early stages of cognitive decline. We leverage the longitudinal Normative Aging Study (NAS) cohort to investigate associations between plasma miRNAs and cognitive function among cognitively normal men. This study includes data from up to 530 NAS participants (median age: 71.0 years) collected from 1996 to 2013, with a total of 1,331 person-visits (equal to 2,471 years of follow up). Global cognitive function was assessed using the Mini-Mental State Examination (MMSE). Plasma miRNAs were profiled using small RNA sequencing. Associations of expression of 381 miRNAs with current cognitive function and rate of change in cognitive function were assessed using linear regression ( In adjusted models, levels of 2 plasma miRNAs were associated with higher MMSE scores ( Circulating miRNAs were associated with both cross-sectional cognitive function and rate of change in cognitive function among cognitively normal men. Further research is needed to elucidate the potential functions of these miRNAs in the CNS and investigate relationships with other neurological outcomes.
Sections du résumé
BACKGROUND
Aging-related cognitive decline is an early symptom of Alzheimer's disease and other dementias, and on its own can have substantial consequences on an individual's ability to perform important everyday functions. Despite increasing interest in the potential roles of extracellular microRNAs (miRNAs) in central nervous system (CNS) pathologies, there has been little research on extracellular miRNAs in early stages of cognitive decline. We leverage the longitudinal Normative Aging Study (NAS) cohort to investigate associations between plasma miRNAs and cognitive function among cognitively normal men.
METHODS
This study includes data from up to 530 NAS participants (median age: 71.0 years) collected from 1996 to 2013, with a total of 1,331 person-visits (equal to 2,471 years of follow up). Global cognitive function was assessed using the Mini-Mental State Examination (MMSE). Plasma miRNAs were profiled using small RNA sequencing. Associations of expression of 381 miRNAs with current cognitive function and rate of change in cognitive function were assessed using linear regression (
RESULTS
In adjusted models, levels of 2 plasma miRNAs were associated with higher MMSE scores (
CONCLUSIONS
Circulating miRNAs were associated with both cross-sectional cognitive function and rate of change in cognitive function among cognitively normal men. Further research is needed to elucidate the potential functions of these miRNAs in the CNS and investigate relationships with other neurological outcomes.
Identifiants
pubmed: 36069796
pii: 204268
doi: 10.18632/aging.204268
pmc: PMC9512498
doi:
Substances chimiques
Fatty Acids
0
MicroRNAs
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
6859-6886Subventions
Organisme : NIEHS NIH HHS
ID : P42 ES030990
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES027747
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG018436
Pays : United States
Organisme : NIEHS NIH HHS
ID : F31 ES030973
Pays : United States
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