[Diagnostic problems in testicular tumours in consultant pathology : A practical guide].
Diagnostische Probleme bei Hodentumoren in der Konsiliarpathologie : Ein praktischer Leitfaden.
Germ cell tumours
Immunohistochemical algorithm
Sex cord stromal tumours
Somatic-type malignancies
Tumours of the testicular adnexa
Journal
Pathologie (Heidelberg, Germany)
ISSN: 2731-7196
Titre abrégé: Pathologie (Heidelb)
Pays: Germany
ID NLM: 9918384887506676
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
accepted:
14
07
2022
pubmed:
8
9
2022
medline:
25
10
2022
entrez:
7
9
2022
Statut:
ppublish
Résumé
The great variety of pathological patterns in germ cell tumours, especially in yolk sac tumours but also the possibility of somatic-type malignancies, can complicate daily diagnosis. For the correct diagnosis, knowledge of morphological aspects and additional immunohistochemical staining can be helpful. Also, rare entities like sex cord stromal tumours, tumours of testicular adnexa or mesenchymal tumours of the spermatic cord can be diagnostically challenging. Die große Vielfalt der histologischen Muster von Keimzelltumoren, insbesondere beim Dottersacktumor, aber auch das Phänomen der somatischen Malignität können die tägliche Diagnostik komplizieren. Verschiedene morphologische Aspekte und immunhistochemische Zusatzuntersuchungen können bei der Diagnosefindung hilfreich sein. Auch das Spektrum seltener Entitäten wie Gonadenstromatumoren, testikuläre Adnextumoren und Weichgewebstumoren des Samenstrangs können zu einer diagnostischen Herausforderung werden.
Autres résumés
Type: Publisher
(ger)
Die große Vielfalt der histologischen Muster von Keimzelltumoren, insbesondere beim Dottersacktumor, aber auch das Phänomen der somatischen Malignität können die tägliche Diagnostik komplizieren. Verschiedene morphologische Aspekte und immunhistochemische Zusatzuntersuchungen können bei der Diagnosefindung hilfreich sein. Auch das Spektrum seltener Entitäten wie Gonadenstromatumoren, testikuläre Adnextumoren und Weichgewebstumoren des Samenstrangs können zu einer diagnostischen Herausforderung werden.
Identifiants
pubmed: 36069909
doi: 10.1007/s00292-022-01103-2
pii: 10.1007/s00292-022-01103-2
doi:
Types de publication
English Abstract
Journal Article
Review
Langues
ger
Sous-ensembles de citation
IM
Pagination
425-433Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
Références
Ahmed T, Bosl GJ, Hajdu SI (1985) Teratoma with malignant transformation in germ cell tumors in men. Cancer 56:860–863. https://doi.org/10.1002/1097-0142(19850815)56:4<860::aid-cncr2820560426>3.0.co;2-3
doi: 10.1002/1097-0142(19850815)56:4<860::AID-CNCR2820560426>3.0.CO;2-3
Alvarado-Cabrero I, Hernández-Toriz N, Paner GP (2014) Clinicopathologic analysis of choriocarcinoma as a pure or predominant component of germ cell tumor of the testis. Am J Surg Pathol 38:111–118. https://doi.org/10.1097/PAS.0b013e3182a2926e
doi: 10.1097/PAS.0b013e3182a2926e
pubmed: 24145647
Angulo JC, González J, Rodríguez N et al (2009) Clinicopathological study of regressed testicular tumors (apparent extragonadal germ cell neoplasms). J Urol 182(5):2303–2310
doi: 10.1016/j.juro.2009.07.045
Anheuser P, Kranz J, Stolle E et al (2019) Testicular epidermoid cysts: a reevaluation. BMC Urol 19:52. https://doi.org/10.1186/s12894-019-0477-1
doi: 10.1186/s12894-019-0477-1
pubmed: 31185974
pmcid: 6561757
Balzer BL, Ulbright TM (2006) Spontaneous regression of testicular germ cell tumors: an analysis of 42 cases. Am J Surg Pathol 30:858–865. https://doi.org/10.1097/01.pas.0000209831.24230.56
doi: 10.1097/01.pas.0000209831.24230.56
pubmed: 16819328
Buck DA, Byrd RH, Holmes CL, Pollock T (2015) Testicular metastasis in a case of squamous cell carcinoma of the lung. Case Rep Oncol 8:133–137. https://doi.org/10.1159/000380814
doi: 10.1159/000380814
pubmed: 25873879
pmcid: 4376918
Bunn R, Liu S, Stokes S et al (2018) Mucinous lung adenocarcinoma metastasis to testis in a 29 year old: a case report. Urology 118:3–5. https://doi.org/10.1016/j.urology.2018.01.016
doi: 10.1016/j.urology.2018.01.016
pubmed: 29548865
Bürger T, Schildhaus H‑U, Inniger R et al (2015) Ovarian-type epithelial tumours of the testis: immunohistochemical and molecular analysis of two serous borderline tumours of the testis. Diagn Pathol 10:118. https://doi.org/10.1186/s13000-015-0342-9
doi: 10.1186/s13000-015-0342-9
pubmed: 26197800
pmcid: 4511533
Carver BS, Shayegan B, Serio A et al (2007) Long-term clinical outcome after postchemotherapy retroperitoneal lymph node dissection in men with residual teratoma. J Clin Oncol 25:1033–1037. https://doi.org/10.1200/JCO.2005.05.4791
doi: 10.1200/JCO.2005.05.4791
pubmed: 17261854
Colecchia M, Necchi A, Paolini B et al (2011) Teratoma with somatic-type malignant components in germ cell tumors of the testis: a clinicopathologic analysis of 40 cases with outcome correlation. Int J Surg Pathol 19:321–327. https://doi.org/10.1177/1066896910390680
doi: 10.1177/1066896910390680
pubmed: 21134986
Davey DD, Ulbright TM, Loehrer PJ et al (1987) The significance of atypia within teratomatous metastases after chemotherapy for malignant germ cell tumors. Cancer 59:533–539. https://doi.org/10.1002/1097-0142(19870201)59:3<533::aid-cncr2820590329>3.0.co;2-x
doi: 10.1002/1097-0142(19870201)59:3<533::AID-CNCR2820590329>3.0.CO;2-X
Donadio AC, Motzer RJ, Bajorin DF et al (2003) Chemotherapy for teratoma with malignant transformation. J Clin Oncol 21:4285–4291. https://doi.org/10.1200/JCO.2003.01.019
doi: 10.1200/JCO.2003.01.019
pubmed: 14645417
Duncan AM (1990) Isochromosome of chromosome 12: clinically useful marker for male germ cell tumors. J Natl Cancer Inst 82:1433. https://doi.org/10.1093/jnci/82.17.1433
doi: 10.1093/jnci/82.17.1433
pubmed: 2167387
Fichtner A, Richter A, Filmar S et al (2020) The detection of isochromosome i(12p) in malignant germ cell tumours and tumours with somatic malignant transformation by the use of quantitative real-time polymerase chain reaction. Histopathology. https://doi.org/10.1111/his.14258
doi: 10.1111/his.14258
pubmed: 32970854
Fichtner A, Richter A, Filmar S et al (2021) Primary mediastinal germ cell tumours: an immunohistochemical and molecular diagnostic approach. Histopathology. https://doi.org/10.1111/his.14560
doi: 10.1111/his.14560
pubmed: 34506648
Fosså A, Fosså SD (1989) Serum lactate dehydrogenase and human choriogonadotrophin in seminoma. Br J Urol 63:408–415. https://doi.org/10.1111/j.1464-410x.1989.tb05228.x
doi: 10.1111/j.1464-410x.1989.tb05228.x
pubmed: 2653557
Honecker F, Aparicio J, Berney D et al (2018) ESMO consensus conference on testicular germ cell cancer: diagnosis, treatment and follow-up. Ann Oncol 29:1658–1686. https://doi.org/10.1093/annonc/mdy217
doi: 10.1093/annonc/mdy217
pubmed: 30113631
de Jong J, Stoop H, Gillis AJM et al (2008) Differential expression of SOX17 and SOX2 in germ cells and stem cells has biological and clinical implications. J Pathol 215:21–30. https://doi.org/10.1002/path.2332
doi: 10.1002/path.2332
pubmed: 18348160
Kao C‑S, Ulbright TM, Young RH, Idrees MT (2014) Testicular embryonal carcinoma: a morphologic study of 180 cases highlighting unusual and unemphasized aspects. Am J Surg Pathol 38:689–697. https://doi.org/10.1097/PAS.0000000000000171
doi: 10.1097/PAS.0000000000000171
pubmed: 24503753
Lau HD, Kao C‑S, Williamson SR et al (2021) Immunohistochemical characterization of 120 testicular sex cord-stromal tumors with an emphasis on the diagnostic utility of SOX9, FOXL2, and SF‑1. Am J Surg Pathol 45:1303–1313. https://doi.org/10.1097/PAS.0000000000001704
doi: 10.1097/PAS.0000000000001704
pubmed: 34232606
Lau SK, Weiss LM, Chu PG (2007) D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30. Mod Pathol 20:320–325. https://doi.org/10.1038/modpathol.3800749
doi: 10.1038/modpathol.3800749
pubmed: 17277761
Looijenga LHJ, Hersmus R, Gillis AJM et al (2006) Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene. Cancer Res 66:290–302. https://doi.org/10.1158/0008-5472.CAN-05-2936
doi: 10.1158/0008-5472.CAN-05-2936
pubmed: 16397242
Magers MJ, Kao C‑S, Cole CD et al (2014) “Somatic-type” malignancies arising from testicular germ cell tumors: a clinicopathologic study of 124 cases with emphasis on glandular tumors supporting frequent yolk sac tumor origin. Am J Surg Pathol 38:1396–1409. https://doi.org/10.1097/PAS.0000000000000262
doi: 10.1097/PAS.0000000000000262
pubmed: 24921638
Malagón HD, Valdez AMC, Moran CA, Suster S (2007) Germ cell tumors with sarcomatous components: a clinicopathologic and immunohistochemical study of 46 cases. Am J Surg Pathol 31:1356–1362. https://doi.org/10.1097/PAS.0b013e318033c7c4
doi: 10.1097/PAS.0b013e318033c7c4
pubmed: 17721191
Morita S, Yoshida A, Goto A et al (2013) High-grade lung adenocarcinoma with fetal lung-like morphology: clinicopathologic, immunohistochemical, and molecular analyses of 17 cases. Am J Surg Pathol 37:924–932. https://doi.org/10.1097/PAS.0b013e31827e1e83
doi: 10.1097/PAS.0b013e31827e1e83
pubmed: 23629442
Motzer RJ, Amsterdam A, Prieto V et al (1998) Teratoma with malignant transformation: diverse malignant histologies arising in men with germ cell tumors. J Urol 159:133–138. https://doi.org/10.1016/s0022-5347(01)64035-7
doi: 10.1016/s0022-5347(01)64035-7
pubmed: 9400455
Müller J, Skakkebaek NE, Parkinson MC (1987) The spermatocytic seminoma: views on pathogenesis. Int J Androl 10:147–156. https://doi.org/10.1111/j.1365-2605.1987.tb00176.x
doi: 10.1111/j.1365-2605.1987.tb00176.x
pubmed: 3583416
Perrone F, Bertolotti A, Montemurro G et al (2014) Frequent mutation and nuclear localization of β‑catenin in sertoli cell tumors of the testis. Am J Surg Pathol 38:66–71. https://doi.org/10.1097/PAS.0b013e31829cdbc6
doi: 10.1097/PAS.0b013e31829cdbc6
pubmed: 24061522
Pratap Singh A, Kumar A, Dhar A et al (2018) Advanced colorectal carcinoma with testicular metastasis in an adolescent: a case report. J Med Case Rep 12:304. https://doi.org/10.1186/s13256-018-1831-8
doi: 10.1186/s13256-018-1831-8
pubmed: 30305152
pmcid: 6180440
Richie JP (2005) OCT4 staining in testicular tumors. A sensitive and specific marker for seminoma and embryonal carcinoma. J Urol 174:569–570. https://doi.org/10.1016/s0022-5347(01)68313-7
doi: 10.1016/s0022-5347(01)68313-7
pubmed: 16006897
Rouvinov K, Neulander EZ, Kan E et al (2017) Testicular metastasis from renal cell carcinoma: a case report and review of the literature. Case Rep Oncol 10:388–391. https://doi.org/10.1159/000473698
doi: 10.1159/000473698
pubmed: 28559825
pmcid: 5436013
Skakkebaek NE (1972) Possible carcinoma-in-situ of the testis. Lancet 2:516–517. https://doi.org/10.1016/s0140-6736(72)91909-5
doi: 10.1016/s0140-6736(72)91909-5
pubmed: 4115573
Ulbright TM, Loehrer PJ, Roth LM et al (1984) The development of non-germ cell malignancies within germ cell tumors. A clinicopathologic study of 11 cases. Cancer 54:1824–1833. https://doi.org/10.1002/1097-0142(19841101)54:9<1824::aid-cncr2820540910>3.0.co;2-j
doi: 10.1002/1097-0142(19841101)54:9<1824::AID-CNCR2820540910>3.0.CO;2-J
Wruck W, Bremmer F, Kotthoff M et al (2021) The pioneer and differentiation factor FOXA2 is a key driver of yolk-sac tumour formation and a new biomarker for paediatric and adult yolk-sac tumours. J Cell Mol Med. https://doi.org/10.1111/jcmm.16222
doi: 10.1111/jcmm.16222
pubmed: 33448076
pmcid: 7875904
Zeng SS, Yamashita T, Kondo M et al (2014) The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma. J Hepatol 60:127–134. https://doi.org/10.1016/j.jhep.2013.08.024
doi: 10.1016/j.jhep.2013.08.024
pubmed: 24012616