CRLF2 Gene in B-cell Acute Lymphoblastic Leukemia.

Journal

Journal of the Association of Genetic Technologists
ISSN: 1523-7834
Titre abrégé: J Assoc Genet Technol
Pays: United States
ID NLM: 9807282

Informations de publication

Date de publication:
2022
Historique:
received: 07 09 2022
accepted: 07 09 2022
entrez: 7 9 2022
pubmed: 8 9 2022
medline: 8 9 2022
Statut: ppublish

Résumé

B-cell acute lymphoblastic leukemia (B-ALL) is a subset of ALL that comprises 75% of ALL cases. There are a variety of chromosome aneuploidy or chromosomal rearrangements implicated in B-ALL. Deregulation of CRLF2 expression is seen in 5-15% of B-ALL patients and occurs primarily via a reciprocal translocation with immunoglobulin heavy chain (IGH), rearrangements of CRLF2, deletion within the PAR1 region of the X and Y chromosomes, and CRLF2 mutations as well as mutations of the CRLF2-involved pathways and are seen in Ph-like B-ALL. They are associated with a poor prognosis. Blinatumomab is an available immunotherapy, and there are currently a few ongoing clinical trials to treat CRLF2 B-ALL. This review focuses on the role of CRLF2 in B-ALL and summarizes the literature regarding its molecular pathways, clinical significance, incidence rates across demographics, therapies, and areas of further research.

Identifiants

PMID: 36070232
pubmed: 36070232

Types de publication

Journal Article

Langues

eng

Pagination

100-105

Informations de copyright

Copyright© by the Association of Genetic Technologists.

Auteurs

Wendy Su (W)

University of California Los Angeles, Los Angeles, CA.
The International Circle of Genetics Studies, Los Angeles, CA.

Alair Zhao (A)

University of California Los Angeles, Los Angeles, CA.
The International Circle of Genetics Studies, Los Angeles, CA.

Jonah Nahoul (J)

University of California Los Angeles, Los Angeles, CA.
The International Circle of Genetics Studies, Los Angeles, CA.

Hailey Mendelsohn (H)

University of California Los Angeles, Los Angeles, CA.
The International Circle of Genetics Studies, Los Angeles, CA.

Bilal Hamid (B)

University of California Los Angeles, Los Angeles, CA.
The International Circle of Genetics Studies, Los Angeles, CA.

Carlos A Tirado (CA)

The International Circle of Genetics Studies, Los Angeles, CA.
Baylor Scott and White Health, Department of Pathology, Temple, TX.

Classifications MeSH