Tandem pore domain acid-sensitive K channel 3 (TASK-3) regulates visual sensitivity in healthy and aging retina.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
09 Sep 2022
09 Sep 2022
Historique:
entrez:
7
9
2022
pubmed:
8
9
2022
medline:
8
9
2022
Statut:
ppublish
Résumé
Retinal ganglion cells (RGCs) not only collect but also integrate visual signals and send them from the retina to the brain. The mechanisms underlying the RGC integration of synaptic activity within retinal circuits have not been fully explored. Here, we identified a pronounced expression of tandem pore domain acid-sensitive potassium channel 3 (TASK-3), a two-pore domain potassium channel (K2P), in RGCs. By using a specific antagonist and TASK-3 knockout mice, we found that TASK-3 regulates the intrinsic excitability and the light sensitivity of RGCs by sensing neuronal activity-dependent extracellular acidification. In vivo, the blockade or loss of TASK-3 dampened pupillary light reflex, visual acuity, and contrast sensitivity. Furthermore, overexpressing TASK-3 specifically in RGCs using an adeno-associated virus approach restored the visual function of TASK-3 knockout mice and aged mice where the expression and function of TASK-3 were reduced. Thus, our results provide evidence that implicates a critical role of K2P in visual processing in the retina.
Identifiants
pubmed: 36070380
doi: 10.1126/sciadv.abn8785
pmc: PMC9451158
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabn8785Références
FEBS Lett. 2013 Jun 27;587(13):1923-8
pubmed: 23669358
J Neurosci. 2003 Dec 10;23(36):11332-41
pubmed: 14672997
J Physiol. 1966 Dec;187(3):517-52
pubmed: 16783910
J Neurosci. 2007 Aug 29;27(35):9329-40
pubmed: 17728447
J Biol Chem. 2002 Feb 15;277(7):5426-32
pubmed: 11733509
Vision Res. 2011 Jul 1;51(13):1610-22
pubmed: 20974168
J Neurophysiol. 1998 Sep;80(3):1327-40
pubmed: 9744942
Neuron. 2001 Dec 20;32(6):1107-17
pubmed: 11754841
Neurosci Bull. 2021 Feb;37(2):145-165
pubmed: 32996060
ChemMedChem. 2012 Jan 2;7(1):123-33
pubmed: 21916012
J Neurosci. 2003 Apr 1;23(7):2645-54
pubmed: 12684450
J Neurosci. 2000 Jun 15;20(12):4462-70
pubmed: 10844015
J Vis. 2007 Nov 30;7(14):7.1-13
pubmed: 18217802
Mol Pharmacol. 2000 Dec;58(6):1204-12
pubmed: 11093755
Hum Gene Ther. 2019 Mar;30(3):257-272
pubmed: 30062914
Vision Res. 2000;40(16):2201-9
pubmed: 10878281
Nat Rev Neurosci. 2007 Apr;8(4):251-61
pubmed: 17375039
J Neurosci. 2008 Jan 9;28(2):456-64
pubmed: 18184788
J Neurophysiol. 1969 May;32(3):339-55
pubmed: 4306897
Neurobiol Aging. 2007 Oct;28(10):1577-93
pubmed: 17010477
Int J Mol Sci. 2019 May 07;20(9):
pubmed: 31067753
Neuron. 2018 Aug 22;99(4):754-767.e4
pubmed: 30017393
Prog Retin Eye Res. 2019 Sep;72:100760
pubmed: 31078724
Sci Rep. 2017 Apr 26;7:46085
pubmed: 28443635
PLoS One. 2011;6(8):e22817
pubmed: 21829655
J Physiol. 2004 Jan 1;554(Pt 1):64-77
pubmed: 14678492
J Physiol. 1978 Mar;276:277-98
pubmed: 650450
Proc Natl Acad Sci U S A. 1990 Aug;87(16):6445-9
pubmed: 1696732
J Neurosci. 2007 May 30;27(22):5994-6005
pubmed: 17537971
J Neurophysiol. 2000 Apr;83(4):1817-29
pubmed: 10758094
Eur J Neurosci. 2008 Apr;27(7):1763-70
pubmed: 18371076
J Med Chem. 2019 Nov 27;62(22):10044-10058
pubmed: 31260312
J Gen Physiol. 2003 Dec;122(6):657-71
pubmed: 14610018
J Physiol. 2016 Nov 15;594(22):6661-6677
pubmed: 27345444
Prog Retin Eye Res. 2005 Nov;24(6):682-720
pubmed: 16027025
J Neurosci. 2010 Dec 1;30(48):16262-71
pubmed: 21123572
Sci Transl Med. 2019 Nov 20;11(519):
pubmed: 31748231
J Biol Chem. 2000 Mar 31;275(13):9340-7
pubmed: 10734076
J Neurophysiol. 2006 Mar;95(3):1992-5
pubmed: 16371457
Nat Neurosci. 2014 Feb;17(2):262-8
pubmed: 24441679
J Neurosci. 2019 Jan 23;39(4):651-662
pubmed: 30504272
Cell Rep. 2014 Sep 11;8(5):1571-82
pubmed: 25199828
J Neurosci. 2004 Feb 4;24(5):1013-22
pubmed: 14762119
J Neurosci. 2000 Jan 15;20(2):568-78
pubmed: 10632586
J Gen Physiol. 1979 Jul;74(1):71-84
pubmed: 479822
J Neurosci. 2003 Jul 9;23(14):6063-73
pubmed: 12853425
Prog Retin Eye Res. 2001 Mar;20(2):139-74
pubmed: 11173250
Science. 2020 May 1;368(6490):527-531
pubmed: 32355031
J Physiol Sci. 2012 Sep;62(5):359-75
pubmed: 22773408
Nature. 2011 Jul 17;476(7358):92-5
pubmed: 21765429
Neuron. 2011 Jul 14;71(1):166-79
pubmed: 21745646