Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention.

Actinin / genetics Cross-Sectional Studies Exercise / physiology Genome-Wide Association Study Humans Leisure Activities Sedentary Behavior

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
09 2022
Historique:
received: 30 11 2021
accepted: 18 07 2022
pubmed: 8 9 2022
medline: 16 9 2022
entrez: 7 9 2022
Statut: ppublish

Résumé

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type II

Identifiants

DOI: 10.1038/s41588-022-01165-1 PMID: 36071172 PMC: PMC9470530
pubmed: 36071172
doi: 10.1038/s41588-022-01165-1
pii: 10.1038/s41588-022-01165-1
pmc: PMC9470530
doi:

Substances chimiques

ACTN3 protein, human 0
Actinin 11003-00-2

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1332-1344

Subventions

Organisme : British Heart Foundation
ID : RG/13/13/30194
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : U01 AG070959
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00011
Pays : United Kingdom
Organisme : British Heart Foundation
ID : SP/16/4/32697
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : P30 ES007033
Pays : United States
Organisme : Department of Health
ID : BRC-1215-2001
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00006/4
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Organisme : British Heart Foundation
ID : RG/18/13/33946
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 217065/Z/19/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00006/1
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C18281/A19169
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK062370
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL105756
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114045
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020541
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : U01 DK062370
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA164973
Pays : United States
Organisme : British Heart Foundation
ID : CH/12/2/29428
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 202802/Z/16/Z
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL149683
Pays : United States
Organisme : Department of Health
ID : BRC-1215-20010
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : UM1 CA182876
Pays : United States

Investigateurs

Behrooz Z Alizadeh (BZ)
H Marike Boezen (HM)
Lude Franke (L)
Morris Swertz (M)
Cisca Wijmenga (C)
Pim van der Harst (P)
Gerjan Navis (G)
Marianne Rots (M)
Bruce H R Wolffenbuttel (BHR)

Informations de copyright

© 2022. The Author(s).

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Auteurs

Zhe Wang (Z)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. zhe.wang@mssm.edu.
ORCID: 0000-0002-8046-4969

Andrew Emmerich (A)

Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0002-0908-9924

Nicolas J Pillon (NJ)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0003-1107-9490

Tim Moore (T)

Division of Cardiology, Department of Medicine, University of California, Los Angeles, CA, USA.
ORCID: 0000-0003-4250-3370

Daiane Hemerich (D)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Marilyn C Cornelis (MC)

Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Eugenia Mazzaferro (E)

The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden.

Siacia Broos (S)

Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Exercise Physiology Research Group, KU Leuven, Leuven, Belgium.
Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Physical Activity, Sports & Health Research Group, KU Leuven, Leuven, Belgium.

Tarunveer S Ahluwalia (TS)

Steno Diabetes Center Copenhagen, Herlev, Denmark.
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
The Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen, Denmark.

Traci M Bartz (TM)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Department of Biostatistics, University of Washington, Seattle, WA, USA.

Amy R Bentley (AR)

Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.

Lawrence F Bielak (LF)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Mike Chong (M)

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

Audrey Y Chu (AY)

Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
GlaxoSmithKline, Cambridge, MA, USA.

Diane Berry (D)

Division of Population, Policy and Practice, Great Ormond Street Hospital Institute for Child Health, University College London, London, UK.

Rajkumar Dorajoo (R)

Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.
Health Services and Systems Research, Duke-NUS Medical School, Singapore, Singapore.

Nicole D Dueker (ND)

John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
Department of Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.

Elisa Kasbohm (E)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Institute of Mathematics and Computer Science, University of Greifswald, Greifswald, Germany.

Bjarke Feenstra (B)

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.

Mary F Feitosa (MF)

Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.

Christian Gieger (C)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.

Mariaelisa Graff (M)

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.

Leanne M Hall (LM)

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.

Toomas Haller (T)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.

Fernando P Hartwig (FP)

Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
MRC Integrative Epidemiology Unit, NIHR Bristol Biomedical Research Center, University of Bristol, Bristol, UK.

David A Hillis (DA)

Genetics, Genomics, and Bioinformatics Graduate Program, University of California, Riverside, CA, USA.

Ville Huikari (V)

Institute of Health Sciences, University of Oulu, Oulu, Finland.

Nancy Heard-Costa (N)

Framingham Heart Study, Framingham, MA, USA.
Department of Neurology, Boston University School of Medicine, Boston, MA, USA.

Christina Holzapfel (C)

Research Unit of Molecular Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.
Institute for Nutritional Medicine, School of Medicine, Technical University of Munich, Munich, Germany.

Anne U Jackson (AU)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.

Åsa Johansson (Å)

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Anja Moltke Jørgensen (AM)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Marika A Kaakinen (MA)

Section of Statistical Multi-omics, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.
Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

Robert Karlsson (R)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Kathleen F Kerr (KF)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Boram Kim (B)

Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.

Chantal M Koolhaas (CM)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Zoltan Kutalik (Z)

University Center for Primary Care and Public Health, University of Lausanne, Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Department of Computational Biology, University of Lausanne, Lausanne, Switzerland.

Vasiliki Lagou (V)

Wellcome Sanger Institute, Cambridge, UK.

Penelope A Lind (PA)

Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
School of Biomedical Science, Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.

Mattias Lorentzon (M)

Geriatric Medicine, Institute of Medicine, University of Gothenburg and Sahlgrenska University Hospital Mölndal, Gothenburg, Sweden.
Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, Australia.

Leo-Pekka Lyytikäinen (LP)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

Massimo Mangino (M)

Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
NIHR Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK.

Christoph Metzendorf (C)

The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden.

Kristine R Monroe (KR)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Alexander Pacolet (A)

Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Exercise Physiology Research Group, KU Leuven, Leuven, Belgium.

Louis Pérusse (L)

Department of Kinesiology, Université Laval, Quebec, Quebec, Canada.
Centre Nutrition Santé et Société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, Quebec, Canada.

Rene Pool (R)

Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.

Rebecca C Richmond (RC)

MRC Integrative Epidemiology Unit and Avon Longitudinal Study of Parents and Children, University of Bristol Medical School, Population Health Sciences and Avon Longitudinal Study of Parents and Children, University of Bristol, Bristol, UK.

Natalia V Rivera (NV)

Respiratory Division, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Rheumatology Division, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Center of Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden.

Sebastien Robiou-du-Pont (S)

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.

Katharina E Schraut (KE)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.

Christina-Alexandra Schulz (CA)

Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Department of Nutrition and Food Sciences, Nutritional Epidemiology, University of Bonn, Bonn, Germany.

Heather M Stringham (HM)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.

Toshiko Tanaka (T)

Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.

Alexander Teumer (A)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.

Constance Turman (C)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Peter J van der Most (PJ)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Mathias Vanmunster (M)

Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Exercise Physiology Research Group, KU Leuven, Leuven, Belgium.

Frank J A van Rooij (FJA)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.

Jana V van Vliet-Ostaptchouk (JV)

Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Xiaoshuai Zhang (X)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
School of Public Health, Department of Biostatistics, Shandong University, Jinan, China.

Jing-Hua Zhao (JH)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Wei Zhao (W)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Zhanna Balkhiyarova (Z)

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Department of Clinical and Experimental Medicine, University of Surrey, Guilford, UK.
People-Centred Artificial Intelligence Institute, University of Surrey, Guilford, UK.

Marie N Balslev-Harder (MN)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Sebastian E Baumeister (SE)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
University of Münster, Münster, Germany.

John Beilby (J)

Diagnostic Genomics, PathWest Laboratory Medicine WA, Perth, Western Australia, Australia.

John Blangero (J)

South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Brownsville, TX, USA.

Dorret I Boomsma (DI)

Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.

Soren Brage (S)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Peter S Braund (PS)

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.

Jennifer A Brody (JA)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.

Marcel Bruinenberg (M)

Lifelines Cohort Study, Groningen, the Netherlands.

Ulf Ekelund (U)

Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway.
Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway.

Ching-Ti Liu (CT)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

John W Cole (JW)

Vascular Neurology, Department of Neurology, University of Maryland School of Medicine and the Baltimore VAMC, Baltimore, MD, USA.

Francis S Collins (FS)

Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD, USA.

L Adrienne Cupples (LA)

Framingham Heart Study, Framingham, MA, USA.
Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Tõnu Esko (T)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.

Stefan Enroth (S)

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Jessica D Faul (JD)

Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.

Lindsay Fernandez-Rhodes (L)

Department of Biobehavioral Health, College of Health and Human Development, Pennsylvania State University, University Park, PA, USA.

Alison E Fohner (AE)

Department of Epidemiology, Institute of Public Health Genetics, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.

Oscar H Franco (OH)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.

Tessel E Galesloot (TE)

Radboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands.

Scott D Gordon (SD)

Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Niels Grarup (N)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Catharina A Hartman (CA)

Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Gerardo Heiss (G)

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.

Jennie Hui (J)

Diagnostic Genomics, PathWest Laboratory Medicine WA, Perth, Western Australia, Australia.
School of Population and Global Health, The University of Western Australia, Perth, Western Australia, Australia.
Busselton Population Medical Research Institute, Busselton, Western Australia, Australia.

Thomas Illig (T)

Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.
Department of Human Genetics, Hannover Medical School, Hannover, Germany.

Russell Jago (R)

Centre for Exercise Nutrition & Health Sciences, School for Policy Studies, University of Bristol, Bristol, UK.

Alan James (A)

Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Western Australia, Perth, Australia.

Peter K Joshi (PK)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Humanity Inc, Boston, MA, USA.

Taeyeong Jung (T)

Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.

Mika Kähönen (M)

Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.

Tuomas O Kilpeläinen (TO)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Woon-Puay Koh (WP)

Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore, Singapore.

Ivana Kolcic (I)

Department of Public Health, University of Split School of Medicine, Split, Croatia.

Peter P Kraft (PP)

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Johanna Kuusisto (J)

Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.

Lenore J Launer (LJ)

Laboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA.

Aihua Li (A)

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.

Allan Linneberg (A)

Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Jian'an Luan (J)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Pedro Marques Vidal (PM)

Division of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Sarah E Medland (SE)

Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
School of Psychology and Faculty of Medicine, University of Queensland, St Lucia, Queensland, Australia.

Yuri Milaneschi (Y)

Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.

Arden Moscati (A)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Bill Musk (B)

Busselton Population Medical Research Institute, Busselton, Western Australia, Australia.

Christopher P Nelson (CP)

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.

Ilja M Nolte (IM)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.

Nancy L Pedersen (NL)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Annette Peters (A)

Institute of Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.

Patricia A Peyser (PA)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Christine Power (C)

Division of Population, Policy and Practice, Great Ormond Street Hospital Institute for Child Health, University College London, London, UK.

Olli T Raitakari (OT)

Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.

Mägi Reedik (M)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.

Alex P Reiner (AP)

Department of Epidemiology, University of Washington, Seattle, WA, USA.

Paul M Ridker (PM)

Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Igor Rudan (I)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.

Kathy Ryan (K)

Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Mark A Sarzynski (MA)

Department of Exercise Science, University of South Carolina, Columbia, SC, USA.

Laura J Scott (LJ)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.

Robert A Scott (RA)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.

Stephen Sidney (S)

Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.

Kristin Siggeirsdottir (K)

Icelandic Heart Association, Kópavogur, Iceland.

Albert V Smith (AV)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Icelandic Heart Association, Kópavogur, Iceland.

Jennifer A Smith (JA)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.

Emily Sonestedt (E)

Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.

Marin Strøm (M)

Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Faculty of Health Sciences, University of the Faroe Islands, Tórshavn, Faroe Islands.

E Shyong Tai (ES)

Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Duke-NUS Medical School, Singapore, Singapore.
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Koon K Teo (KK)

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.

Barbara Thorand (B)

Institute of Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.

Anke Tönjes (A)

Department of Medicine, University of Leipzig, Leipzig, Germany.

Angelo Tremblay (A)

Department of Kinesiology, Université Laval, Quebec, Quebec, Canada.
Centre Nutrition Santé et Société (NUTRISS), Institute of Nutrition and Functional Foods (INAF), Université Laval, Quebec, Quebec, Canada.

Andre G Uitterlinden (AG)

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.

Jagadish Vangipurapu (J)

Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.

Natasja van Schoor (N)

Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, the Netherlands.

Uwe Völker (U)

German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.

Gonneke Willemsen (G)

Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.

Kayleen Williams (K)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Quenna Wong (Q)

Department of Biostatistics, University of Washington, Seattle, WA, USA.

Huichun Xu (H)

Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.

Kristin L Young (KL)

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.

Jian Min Yuan (JM)

Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

M Carola Zillikens (MC)

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.

Alan B Zonderman (AB)

Laboratory of Epidemiology and Population Science, National Instiute on Aging, National Institutes of Health, Bethesda, MD, USA.

Adam Ameur (A)

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0001-6085-6749

Stefania Bandinelli (S)

Geriatric Unit, Azienda USL Toscana Centro, Florence, Italy.

Joshua C Bis (JC)

Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-3409-1110

Michael Boehnke (M)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-6442-7754

Claude Bouchard (C)

Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
ORCID: 0000-0002-0048-491X

Daniel I Chasman (DI)

Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-3357-0862

George Davey Smith (GD)

MRC Integrative Epidemiology Unit, NIHR Bristol Biomedical Research Center, University of Bristol, Bristol, UK.
Population Health Science, Bristol Medical School, NIHR Bristol Biomedical Research Center, University of Bristol, Bristol, UK.
ORCID: 0000-0002-1407-8314

Eco J C de Geus (EJC)

Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
Amsterdam Public Health Research Institute, Amsterdam UMC, Amsterdam, the Netherlands.
ORCID: 0000-0001-6022-2666

Louise Deldicque (L)

Faculty of Movement and Rehabilitation Sciences, Institute of Neuroscience, UC Louvain, Louvain-la-Neuve, Belgium.

Marcus Dörr (M)

German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.
Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany.
ORCID: 0000-0001-7471-475X

Michele K Evans (MK)

Laboratory of Epidemiology and Population Science, National Instiute on Aging, National Institutes of Health, Bethesda, MD, USA.

Luigi Ferrucci (L)

Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
ORCID: 0000-0002-6273-1613

Myriam Fornage (M)

Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, TX, USA.
ORCID: 0000-0003-0677-8158

Caroline Fox (C)

Genetics and Pharmacogenomics (GpGx), Merck Research Labs, Boston, MA, USA.

Theodore Garland (T)

Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, Riverside, CA, USA.
ORCID: 0000-0002-7916-3552

Vilmundur Gudnason (V)

Icelandic Heart Association, Kópavogur, Iceland.
Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

Ulf Gyllensten (U)

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0002-6316-3355

Torben Hansen (T)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0001-8748-3831

Caroline Hayward (C)

MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.

Bernardo L Horta (BL)

Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
ORCID: 0000-0001-9843-412X

Elina Hyppönen (E)

Australian Centre for Precision Health, Unit of Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Population, Policy and Practice, Great Ormond Street Hospital Institute for Child Health, University College London, London, UK.
ORCID: 0000-0003-3670-9399

Marjo-Riitta Jarvelin (MR)

Institute of Health Sciences, University of Oulu, Oulu, Finland.
Department of Epidemiology and Biostatistics and HPA-MRC Center, School of Public Health, Imperial College London, London, UK.

W Craig Johnson (WC)

Department of Biostatistics, University of Washington, Seattle, WA, USA.
ORCID: 0000-0002-3161-3753

Sharon L R Kardia (SLR)

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.

Lambertus A Kiemeney (LA)

Radboud Institute for Health Sciences, Department for Health Evidence, Radboud University Medical Center, Nijmegen, the Netherlands.
ORCID: 0000-0002-2368-1326

Markku Laakso (M)

Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
ORCID: 0000-0002-3394-7749

Claudia Langenberg (C)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Computational Medicine, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
ORCID: 0000-0002-5017-7344

Terho Lehtimäki (T)

Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
Finnish Cardiovascular Research Center - Tampere, Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
ORCID: 0000-0002-2555-4427

Loic Le Marchand (LL)

Epidemiology Program, University of Hawaii Cancer Center, University of Hawaii at Manoa, Honolulu, HI, USA.

Patrik K E Magnusson (PKE)

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-7315-7899

Nicholas G Martin (NG)

Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0003-4069-8020

Mads Melbye (M)

Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
K.G.Jebsen Center for Genetic Epidemiology, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Center for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.
ORCID: 0000-0001-8264-6785

Andres Metspalu (A)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
ORCID: 0000-0002-3718-796X

David Meyre (D)

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
ORCID: 0000-0003-4850-7444

Kari E North (KE)

Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA.
ORCID: 0000-0002-8903-0366

Claes Ohlsson (C)

Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Drug Treatment, Sahlgrenska University Hospital, Gothenburg, Sweden.
ORCID: 0000-0002-9633-2805

Albertine J Oldehinkel (AJ)

Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0003-3925-3913

Marju Orho-Melander (M)

Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
ORCID: 0000-0002-3578-2503

Guillaume Pare (G)

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.
ORCID: 0000-0002-6795-4760

Taesung Park (T)

Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.
Department of Statistics, Seoul National University, Seoul, South Korea.
ORCID: 0000-0002-8294-590X

Oluf Pedersen (O)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0002-3321-3972

Brenda W J H Penninx (BWJH)

Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands.

Tune H Pers (TH)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0003-0207-4831

Ozren Polasek (O)

University of Split School of Medicine, Split, Croatia.
ORCID: 0000-0002-5765-1862

Inga Prokopenko (I)

Department of Clinical and Experimental Medicine, University of Surrey, Guilford, UK.
People-Centred Artificial Intelligence Institute, University of Surrey, Guilford, UK.
UMR 8199 - EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France.
ORCID: 0000-0003-1624-7457

Charles N Rotimi (CN)

Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0001-5759-053X

Nilesh J Samani (NJ)

Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.
NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.

Xueling Sim (X)

Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
ORCID: 0000-0002-1233-7642

Harold Snieder (H)

Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0003-1949-2298

Thorkild I A Sørensen (TIA)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0003-4821-430X

Tim D Spector (TD)

Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.
ORCID: 0000-0002-9795-0365

Nicholas J Timpson (NJ)

MRC Integrative Epidemiology Unit, University of Bristol Medical School, University of Bristol, Bristol, UK.
ORCID: 0000-0002-7141-9189

Rob M van Dam (RM)

Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.

Nathalie van der Velde (N)

Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Section of Geriatrics, Department of Internal Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Amsterdam Public Health, Aging and Later Life, Amsterdam, the Netherlands.

Cornelia M van Duijn (CM)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Nuffield Department of Population Health, University of Oxford, Oxford, UK.

Peter Vollenweider (P)

Division of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Henry Völzke (H)

Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany.

Trudy Voortman (T)

Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
ORCID: 0000-0003-2830-6813

Gérard Waeber (G)

Division of Internal Medicine, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
ORCID: 0000-0003-4193-788X

Nicholas J Wareham (NJ)

MRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-1422-2993

David R Weir (DR)

Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-1661-2402

Heinz-Erich Wichmann (HE)

Institute of Epidemiology, Helmholtz Zentrum München -Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH), Munich, Germany.

James F Wilson (JF)

Centre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-5751-9178

Andrea L Hevener (AL)

Division of Endocrinology, Department of Medicine, University of California, Los Angeles, CA, USA.

Anna Krook (A)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0002-0891-0258

Juleen R Zierath (JR)

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
ORCID: 0000-0001-6891-7497

Martine A I Thomis (MAI)

Faculty of Movement and Rehabilitation Sciences, Department of Movement Sciences - Physical Activity, Sports & Health Research Group, KU Leuven, Leuven, Belgium.
ORCID: 0000-0001-9093-2191

Ruth J F Loos (RJF)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-8532-5087

Marcel den Hoed (MD)

The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden. marcel.den_hoed@igp.uu.se.
ORCID: 0000-0001-8081-428X

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Actinine › Genome-wide association analyses of physical...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Genome-wide association analyses of physical...
questionsmedicales.fr › Activités humaines › Exercice physique › Genome-wide association analyses of physical...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genome-wide association analyses of physical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genome-wide association analyses of physical...
questionsmedicales.fr › Activités humaines › Activités de loisirs › Genome-wide association analyses of physical...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Mode de vie › Mode de vie sédentaire › Genome-wide association analyses of physical...