Lung recruitment after cardiac arrest during procurement of atelectatic donor lungs is a protective measure in lung transplantation.
Lung transplantation (LTx)
atelectasis
lung recruitment maneuver
protective procurement
Journal
Journal of thoracic disease
ISSN: 2072-1439
Titre abrégé: J Thorac Dis
Pays: China
ID NLM: 101533916
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
19
02
2022
accepted:
01
06
2022
entrez:
8
9
2022
pubmed:
9
9
2022
medline:
9
9
2022
Statut:
ppublish
Résumé
Brain-dead donors are susceptible to pulmonary atelectasis (AT). In procurement surgery, lung recruitment under circulatory conditions and cold-flushing for atelectatic donor lungs often provoke graft injury due to the acute blood inflow. We hypothesized that lung recruitment without blood circulation can mitigate graft injury. This study aimed to examine the benefits of lung recruitment subsequent to cardiac arrest using a porcine lung-transplant model. Thirteen donor pigs were categorized into the non-atelectatic (No-AT) group (n=3) representing a healthy control group; AT-BCR group (n=5), in which AT was reverted by conventional blood-circulated recruitment (BCR); and AT-no-BCR group (n=5), in which AT was reverted by no-BCR following circulatory arrest. In the atelectatic donor models, the left main bronchus was ligated for 24 hours prior to lung procurement. Left lung transplantation (LTx) was subsequently performed in the thirteen recipient pigs. After 6 hours evaluation, the recipients were euthanized and the lung grafts were excised. The post-transplant PaO Lung recruitment without circulation after circulatory arrest could be more protective for atelectatic donor lung than the conventional procedure.
Sections du résumé
Background
UNASSIGNED
Brain-dead donors are susceptible to pulmonary atelectasis (AT). In procurement surgery, lung recruitment under circulatory conditions and cold-flushing for atelectatic donor lungs often provoke graft injury due to the acute blood inflow. We hypothesized that lung recruitment without blood circulation can mitigate graft injury. This study aimed to examine the benefits of lung recruitment subsequent to cardiac arrest using a porcine lung-transplant model.
Methods
UNASSIGNED
Thirteen donor pigs were categorized into the non-atelectatic (No-AT) group (n=3) representing a healthy control group; AT-BCR group (n=5), in which AT was reverted by conventional blood-circulated recruitment (BCR); and AT-no-BCR group (n=5), in which AT was reverted by no-BCR following circulatory arrest. In the atelectatic donor models, the left main bronchus was ligated for 24 hours prior to lung procurement. Left lung transplantation (LTx) was subsequently performed in the thirteen recipient pigs. After 6 hours evaluation, the recipients were euthanized and the lung grafts were excised.
Results
UNASSIGNED
The post-transplant PaO
Conclusions
UNASSIGNED
Lung recruitment without circulation after circulatory arrest could be more protective for atelectatic donor lung than the conventional procedure.
Identifiants
pubmed: 36071787
doi: 10.21037/jtd-22-226
pii: jtd-14-08-2802
pmc: PMC9442530
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2802-2811Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
2022 Journal of Thoracic Disease. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-22-226/coif). The authors have no conflicts of interest to declare.
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