Sleep architecture and emotional inhibition processing in adolescents hospitalized during a suicidal crisis.
adolescence
emotional processing
event related potentials
inhibition
sleep
suicide
Journal
Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006
Informations de publication
Date de publication:
2022
2022
Historique:
received:
15
04
2022
accepted:
26
07
2022
entrez:
8
9
2022
pubmed:
9
9
2022
medline:
9
9
2022
Statut:
epublish
Résumé
Suicide is the second leading cause of death in adolescents. Sleep disturbances could alter inhibitory processes and contribute to dangerous behaviors in this critical developmental period. Adolescents in suicidal crisis have been shown to have lighter sleep compared to healthy controls. Additionally, suicidal adolescents have lower neural resources mobilized by emotionally charged inhibition processing. The present exploratory study aimed to determine how sleep architecture in suicidal adolescents may relate to inhibition processing in response to emotional stimuli. Ten adolescents between 12 and 17 years of age with a diagnosis of major depressive disorder and who attempted suicide were recruited while hospitalized for a suicidal crisis in a psychiatric inpatient unit. Event-related potentials (ERPs) were recorded prior to bedtime during a Go/NoGo task involving pictures of sad, happy, and neutral faces. Polysomnography was then recorded throughout the night. Pearson correlations were conducted to investigate how inhibition performance and ERP parameters reflecting inhibition processing (i.e., P3d and N2d derived from difference waveform calculated as NoGo minus Go trials) relate to sleep architecture. Poorer inhibition accuracy in response to emotional stimuli was significantly correlated with shorter REM sleep latency, higher REM sleep, and more frequent nocturnal awakenings. The P3d in response to sad faces was negatively correlated with NREM2 sleep and positively correlated with NREM3 sleep. No such association with the P3d was found for happy or neutral stimuli. There were no significant correlations for the N2d. Altered sleep in adolescents with depression who are in a suicidal crisisis associated with behavioral inhibition difficulties and fewer neural resources mobilized by inhibitory processes in emotionally charged contexts. This highlights the importance of addressing sleep disturbances while managing suicidal crises in adolescents.
Sections du résumé
Background
UNASSIGNED
Suicide is the second leading cause of death in adolescents. Sleep disturbances could alter inhibitory processes and contribute to dangerous behaviors in this critical developmental period. Adolescents in suicidal crisis have been shown to have lighter sleep compared to healthy controls. Additionally, suicidal adolescents have lower neural resources mobilized by emotionally charged inhibition processing. The present exploratory study aimed to determine how sleep architecture in suicidal adolescents may relate to inhibition processing in response to emotional stimuli.
Methods
UNASSIGNED
Ten adolescents between 12 and 17 years of age with a diagnosis of major depressive disorder and who attempted suicide were recruited while hospitalized for a suicidal crisis in a psychiatric inpatient unit. Event-related potentials (ERPs) were recorded prior to bedtime during a Go/NoGo task involving pictures of sad, happy, and neutral faces. Polysomnography was then recorded throughout the night. Pearson correlations were conducted to investigate how inhibition performance and ERP parameters reflecting inhibition processing (i.e., P3d and N2d derived from difference waveform calculated as NoGo minus Go trials) relate to sleep architecture.
Results
UNASSIGNED
Poorer inhibition accuracy in response to emotional stimuli was significantly correlated with shorter REM sleep latency, higher REM sleep, and more frequent nocturnal awakenings. The P3d in response to sad faces was negatively correlated with NREM2 sleep and positively correlated with NREM3 sleep. No such association with the P3d was found for happy or neutral stimuli. There were no significant correlations for the N2d.
Conclusion
UNASSIGNED
Altered sleep in adolescents with depression who are in a suicidal crisisis associated with behavioral inhibition difficulties and fewer neural resources mobilized by inhibitory processes in emotionally charged contexts. This highlights the importance of addressing sleep disturbances while managing suicidal crises in adolescents.
Identifiants
pubmed: 36072454
doi: 10.3389/fpsyt.2022.920789
pmc: PMC9441873
doi:
Types de publication
Journal Article
Langues
eng
Pagination
920789Informations de copyright
Copyright © 2022 Tavakoli, Lanthier, Porteous, Boafo, De Koninck and Robillard.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neuropsychobiology. 1994;30(1):1-3
pubmed: 7969851
Lancet. 2009 Apr 18;373(9672):1372-81
pubmed: 19376453
J Child Psychol Psychiatry. 2006 Mar-Apr;47(3-4):296-312
pubmed: 16492261
Pediatrics. 2003 Feb;111(2):302-7
pubmed: 12563055
Clin EEG Neurosci. 2021 Jan;52(1):29-37
pubmed: 32579028
Brain Sci. 2022 Jun 07;12(6):
pubmed: 35741631
Biol Psychiatry. 1996 Jul 15;40(2):116-22
pubmed: 8793043
Neuroimage. 2001 May;13(5):786-93
pubmed: 11304075
J Abnorm Psychol. 2007 Aug;116(3):484-90
pubmed: 17696704
Sleep. 2004 Nov 1;27(7):1351-8
pubmed: 15586788
Sleep. 2006 Mar;29(3):351-8
pubmed: 16553021
Curr Psychiatry Rep. 2014 Nov;16(11):500
pubmed: 25200984
Clin EEG Neurosci. 2021 Dec 13;:15500594211063311
pubmed: 34894813
J Adolesc Health. 2014 Aug;55(2):287-92
pubmed: 24602612
Dev Cogn Neurosci. 2018 Aug;32:67-79
pubmed: 29525452
Prog Brain Res. 2010;185:105-29
pubmed: 21075236
J Clin Sleep Med. 2007 Mar 15;3(2):121-31
pubmed: 17557422
J Youth Adolesc. 2021 Oct;50(10):2067-2078
pubmed: 34244923
Sleep Med. 2020 Feb;66:33-50
pubmed: 31786427
Int J Mol Sci. 2019 Jan 31;20(3):
pubmed: 30708948
J Affect Disord. 2016 May 15;196:101-8
pubmed: 26919059
Child Psychiatry Hum Dev. 2011 Dec;42(6):724-40
pubmed: 21701911
Noro Psikiyatr Ars. 2020 Sep 21;57(4):312-317
pubmed: 33354125
Trends Neurosci. 2019 Sep;42(9):604-616
pubmed: 31443912
Front Psychol. 2011 Mar 16;2:39
pubmed: 21716604
J Am Acad Child Adolesc Psychiatry. 2008 Feb;47(2):148-155
pubmed: 18176336
PLoS One. 2015 Dec 10;10(12):e0142361
pubmed: 26658074
Neurosci Biobehav Rev. 2016 Nov;70:106-120
pubmed: 27545755
Cogn Emot. 2016 Aug;30(5):999-1007
pubmed: 25978547
Psychiatry Res. 2015 Feb 28;225(3):631-7
pubmed: 25510907
Neuropsychiatr Dis Treat. 2007 Dec;3(6):735-43
pubmed: 19300608
J Neurosci Methods. 2015 Jul 30;250:47-63
pubmed: 25791012
Am J Psychiatry. 2001 May;158(5):735-41
pubmed: 11329395
Aging Ment Health. 2004 Nov;8(6):486-97
pubmed: 15724830
J Psychiatry Neurosci. 2015 Jan;40(1):28-37
pubmed: 25203899
Assessment. 2001 Dec;8(4):443-54
pubmed: 11785588
Depress Anxiety. 2012 Mar;29(3):180-6
pubmed: 22147587
Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Oct;4(10):902-912
pubmed: 31399392
J Affect Disord. 1990 May;19(1):63-75
pubmed: 2140847
Biochem Pharmacol. 2021 Sep;191:114438
pubmed: 33545116
Front Psychiatry. 2018 Mar 19;9:85
pubmed: 29615936
Sleep Med. 2019 Apr;56:41-46
pubmed: 30737143
Psychol Bull. 2010 May;136(3):375-89
pubmed: 20438143
J Affect Disord. 2010 Jun;123(1-3):138-49
pubmed: 19819558
Int J Psychophysiol. 2013 Aug;89(2):218-28
pubmed: 23711996
Acta Psychiatr Scand. 2019 May;139(5):454-463
pubmed: 30865285
J Nerv Ment Dis. 1999 Dec;187(12):730-5
pubmed: 10665467
Biol Psychiatry. 1997 Oct 1;42(7):577-84
pubmed: 9376454
Behav Brain Res. 2011 Mar 1;217(2):463-6
pubmed: 20888369
Sleep. 2004 Jun 15;27(4):774-83
pubmed: 15283014
Am Psychol. 1999 May;54(5):317-26
pubmed: 10354802
Sleep. 2004 Nov 1;27(7):1255-73
pubmed: 15586779
Sleep Med. 2014 Feb;15(2):248-54
pubmed: 24424101
Sleep. 2022 May 12;45(5):
pubmed: 35554572
Curr Psychiatry Rep. 2015 Mar;17(3):554
pubmed: 25698339
Sleep Med Rev. 2017 Feb;31:6-16
pubmed: 26899742
Biol Psychiatry. 2008 May 15;63(10):927-34
pubmed: 18452757
Can J Psychiatry. 2012 Apr;57(4):254-62
pubmed: 22480591
PLoS One. 2020 Dec 2;15(12):e0243053
pubmed: 33264336
PLoS One. 2014 Feb 25;9(2):e87763
pubmed: 24586290
Acta Psychol (Amst). 1999 Apr;101(2-3):267-91
pubmed: 10344188
Physiol Behav. 2014 Jan 17;123:168-73
pubmed: 24184508
Nat Sci Sleep. 2017 Sep 14;9:213-226
pubmed: 29075143
J Consult Clin Psychol. 2008 Feb;76(1):84-91
pubmed: 18229986
J Clin Psychiatry. 2012 Sep;73(9):e1160-7
pubmed: 23059158
Heliyon. 2019 Oct 23;5(10):e02696
pubmed: 31687519
Clin Psychol Rev. 2006 Aug;26(4):379-95
pubmed: 16504359
Neuropsychopharmacology. 2020 Jan;45(1):74-89
pubmed: 31071719
Sleep. 2019 Apr 1;42(4):
pubmed: 30649563
J Abnorm Psychol. 2010 Aug;119(3):616-22
pubmed: 20677851
Arch Gen Psychiatry. 2002 Jul;59(7):597-604
pubmed: 12090812
Sleep Med. 2011 Feb;12(2):110-8
pubmed: 21257344
CNS Neurosci Ther. 2016 Nov;22(11):915-920
pubmed: 27534369
J Psychiatr Res. 2009 Feb;43(5):526-31
pubmed: 18778837
J Sleep Res. 2001 Sep;10(3):165-72
pubmed: 11696069