Effects of omega-3 polyunsaturated fatty acid supplementation on cognitive functioning in youth at ultra-high risk for psychosis: secondary analysis of the NEURAPRO randomised controlled trial.
Cognition
clinical high risk
early intervention
psychotic disorders
randomised controlled trial
Journal
BJPsych open
ISSN: 2056-4724
Titre abrégé: BJPsych Open
Pays: England
ID NLM: 101667931
Informations de publication
Date de publication:
08 Sep 2022
08 Sep 2022
Historique:
entrez:
8
9
2022
pubmed:
9
9
2022
medline:
9
9
2022
Statut:
epublish
Résumé
Cognitive impairments are well-established features of psychotic disorders and are present when individuals are at ultra-high risk for psychosis. However, few interventions target cognitive functioning in this population. To investigate whether omega-3 polyunsaturated fatty acid ( Data ( The placebo group showed a modest greater improvement over time than the omega-3 supplementation group for motor speed ( We found no evidence to support the use of omega-3 supplementation to improve cognitive functioning in ultra-high risk individuals. The biomarker analysis suggests that this finding is unlikely to be attributed to poor adherence or consumption of non-trial
Sections du résumé
BACKGROUND
BACKGROUND
Cognitive impairments are well-established features of psychotic disorders and are present when individuals are at ultra-high risk for psychosis. However, few interventions target cognitive functioning in this population.
AIMS
OBJECTIVE
To investigate whether omega-3 polyunsaturated fatty acid (
METHOD
METHODS
Data (
RESULTS
RESULTS
The placebo group showed a modest greater improvement over time than the omega-3 supplementation group for motor speed (
CONCLUSIONS
CONCLUSIONS
We found no evidence to support the use of omega-3 supplementation to improve cognitive functioning in ultra-high risk individuals. The biomarker analysis suggests that this finding is unlikely to be attributed to poor adherence or consumption of non-trial
Identifiants
pubmed: 36073014
doi: 10.1192/bjo.2022.572
pii: S2056472422005725
pmc: PMC9534907
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e165Subventions
Organisme : Stanley Medical Research Institute
ID : 07TGF-1102
Organisme : University of Melbourne
ID : Dame Kate Campbell Fellowship
Organisme : National Health and Medical Research Council
ID : Australia Program (566529)
Organisme : National Health and Medical Research Council
ID : Career Development Fellowship (1027532)
Organisme : National Health and Medical Research Council
ID : Career Development Fellowship (1141207)
Organisme : National Health and Medical Research Council
ID : Senior Principal Research Fellowship (1060996)
Organisme : National Health and Medical Research Council
ID : Senior Research Fellowship (1080963)
Organisme : National Health and Medical Research Council
ID : Senior Research Fellowship (566593)
Références
Biol Psychiatry. 2020 Feb 1;87(3):243-252
pubmed: 31690495
Schizophr Bull. 2014 Jul;40(4):744-55
pubmed: 23770934
Neurosci Biobehav Rev. 2020 May;112:420-436
pubmed: 32070694
Sao Paulo Med J. 2012;130(6):419
pubmed: 23338743
Psychiatr Serv. 2011 Apr;62(4):411-7
pubmed: 21459993
Exp Gerontol. 2017 May;91:39-50
pubmed: 28213052
Schizophr Res. 2008 Jul;102(1-3):108-15
pubmed: 18495435
Nat Commun. 2015 Aug 11;6:7934
pubmed: 26263244
Mol Psychiatry. 2014 Mar;19(3):317-24
pubmed: 23478748
Schizophr Res. 2020 Dec;226:5-12
pubmed: 30967316
JAMA Psychiatry. 2013 Aug;70(8):793-802
pubmed: 23739772
JAMA Psychiatry. 2016 Dec 01;73(12):1239-1248
pubmed: 27806157
Biomed Pharmacother. 2006 Nov;60(9):502-7
pubmed: 17045449
Schizophr Res. 2012 May;137(1-3):110-7
pubmed: 22377102
Schizophr Res. 2004 Jun 1;68(2-3):283-97
pubmed: 15099610
Front Psychiatry. 2014 Feb 04;5:11
pubmed: 24550848
Schizophr Bull. 2019 Sep 11;45(5):1101-1111
pubmed: 30321434
Psychiatry Res. 2015 Jul 30;228(1):174-6
pubmed: 25979466
Am J Psychiatry. 2001 Dec;158(12):2071-4
pubmed: 11729030
Can J Psychiatry. 2013 Jan;58(1):5-12
pubmed: 23327750
JAMA Psychiatry. 2017 Jan 01;74(1):19-27
pubmed: 27893018
Early Interv Psychiatry. 2021 Aug;15(4):874-881
pubmed: 32893462
Nutr Neurosci. 2011 Sep;14(5):216-25
pubmed: 22005286
Transl Psychiatry. 2017 Aug 29;7(8):e1220
pubmed: 28850110
Lipids. 2004 Oct;39(10):955-61
pubmed: 15691017
World Psychiatry. 2017 Oct;16(3):227-235
pubmed: 28941101
J Clin Med. 2016 Jul 27;5(8):
pubmed: 27472373
JAMA Psychiatry. 2021 Jun 16;:
pubmed: 34132736
J Psychopharmacol. 2015 Jul;29(7):753-63
pubmed: 26040902
Br J Psychiatry. 1979 Apr;134:382-9
pubmed: 444788
Br J Nutr. 2014 Sep 14;112(5):812-20
pubmed: 24933212
Pharmacol Res. 2007 Mar;55(3):217-23
pubmed: 17324586
World Psychiatry. 2019 Oct;18(3):308-324
pubmed: 31496103
Aust N Z J Psychiatry. 2005 Nov-Dec;39(11-12):964-71
pubmed: 16343296
Neurobiol Aging. 2012 Jul;33(7):1482.e17-29
pubmed: 22305186
Early Interv Psychiatry. 2017 Oct;11(5):418-428
pubmed: 26279065
Psychoneuroendocrinology. 2021 May;127:105200
pubmed: 33740587
Addiction. 2002 Sep;97(9):1183-94
pubmed: 12199834