Perinatal exposure to tributyltin affects feeding behavior and expression of hypothalamic neuropeptide Y in the paraventricular nucleus of adult mice.
NPY
development
endocrine disrupting chemicals
feeding behavior
hypothalamic circuits
paraventricular hypothalamic nucleus
sexual dimorphism
Journal
Journal of anatomy
ISSN: 1469-7580
Titre abrégé: J Anat
Pays: England
ID NLM: 0137162
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
revised:
08
08
2022
received:
13
05
2022
accepted:
29
08
2022
pubmed:
9
9
2022
medline:
28
1
2023
entrez:
8
9
2022
Statut:
ppublish
Résumé
Organotins such as tributyltin chloride (TBT), are highly diffused environmental pollutants, which act as metabolism disrupting chemicals, i.e. may interfere with fat tissue differentiation, as well as with neuroendocrine circuits, thus impairing the control of energetic balance. We have previously demonstrated that adult exposure to TBT altered the expression of neuropeptides in the hypothalamus. In this study, we orally administered daily a solution containing oil, or TBT (0.25, 2.5, or 25 μg/kg body weight/day) to pregnant females from gestational day 8 until birth, and to their pups from day 0 until post-natal day 21. Our results showed that TBT exposure of female mice during gestation and of pups during lactation permanently altered the feeding efficiency of pups of both sexes and subcutaneous fat distribution in adult males. In addition, the neuropeptide Y system was affected at the level of the paraventricular nucleus, with a decrease in immunoreactivity in both sexes (significant in females for all TBT doses and in males only for intermediate TBT doses), while no effect was observed in other hypothalamic areas (arcuate, ventromedial and dorsomedial nuclei). Metabolic syndrome, as well as obesity and diabetes, which are significant health issues, are considered multifactorial diseases and may be caused by exposure to metabolic disruptors, both in adults and during perinatal life. In addition, our work indicates that TBT doses defined as the tolerably daily intake had a profound and sex-specific long-term effect.
Identifiants
pubmed: 36073672
doi: 10.1111/joa.13766
pmc: PMC9877477
doi:
Substances chimiques
tributyltin
4XDX163P3D
Neuropeptide Y
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
235-244Informations de copyright
© 2022 The Authors. Journal of Anatomy published by John Wiley & Sons Ltd on behalf of Anatomical Society.
Références
J Endocrinol. 2017 Jul;234(1):41-56
pubmed: 28455431
Mol Cell Endocrinol. 2018 Jan 15;460:246-257
pubmed: 28774778
Endocrinology. 1998 Jul;139(7):3262-70
pubmed: 9645702
Regul Pept. 1998 Sep 25;75-76:117-26
pubmed: 9802401
Endocrinology. 2006 Jun;147(6 Suppl):S50-5
pubmed: 16690801
Vitam Horm. 2014;94:277-325
pubmed: 24388195
Environ Int. 2008 Feb;34(2):292-308
pubmed: 17959247
Neurosci Biobehav Rev. 2016 Aug;67:2-8
pubmed: 27113294
Environ Toxicol Pharmacol. 2018 Jun;60:202-208
pubmed: 29738946
Fundam Clin Pharmacol. 1990;4(3):307-40
pubmed: 2198214
Front Endocrinol (Lausanne). 2018 Jan 08;8:366
pubmed: 29358929
Proc Biol Sci. 2011 Jun 7;278(1712):1626-32
pubmed: 21106594
Cell Metab. 2008 May;7(5):410-20
pubmed: 18460332
Proc Nutr Soc. 2001 Aug;60(3):319-28
pubmed: 11681806
Mar Pollut Bull. 2017 Aug 15;121(1-2):404-410
pubmed: 28629811
J Toxicol Environ Health A. 2008;71(6):384-95
pubmed: 18246498
Front Endocrinol (Lausanne). 2019 Jan 09;9:766
pubmed: 30687229
J Anat. 2023 Feb;242(2):235-244
pubmed: 36073672
Cell Tissue Res. 2018 Dec;374(3):587-594
pubmed: 30078105
Expert Opin Ther Pat. 2009 Oct;19(10):1401-15
pubmed: 19743896
Brain Res. 2000 Jan 31;854(1-2):122-9
pubmed: 10784113
Neurosci Biobehav Rev. 2020 Dec;119:333-347
pubmed: 33045245
Int J Mol Sci. 2018 Jun 02;19(6):
pubmed: 29865233
Mar Pollut Bull. 2017 Dec 15;125(1-2):282-288
pubmed: 28847633
Environ Health. 2015 Jun 20;14:54
pubmed: 26092037
J Toxicol Sci. 2015 Aug;40(4):459-68
pubmed: 26165642
Am J Physiol Regul Integr Comp Physiol. 2003 Oct;285(4):R791-9
pubmed: 12816743
Endokrynol Pol. 2014;65(6):485-90
pubmed: 25554618
Reprod Toxicol. 2017 Mar;68:3-33
pubmed: 27760374
Endocrinology. 2002 Dec;143(12):4513-9
pubmed: 12446577
Annu Rev Physiol. 2008;70:537-56
pubmed: 17937601
Horm Behav. 2001 Sep;40(2):252-65
pubmed: 11534990
Toxicol Sci. 2021 Apr 12;180(2):342-355
pubmed: 33481012
Neuropeptides. 1984 Jun;4(4):319-24
pubmed: 6382043
Andrology. 2016 Jul;4(4):723-34
pubmed: 27310180
Environ Pollut. 2018 Oct;241:636-645
pubmed: 29902746
Mol Endocrinol. 2010 Mar;24(3):526-39
pubmed: 20160124
J Vis Exp. 2012 Sep 15;(67):e4389
pubmed: 23007862
Regul Pept. 2000 Aug 25;92(1-3):1-7
pubmed: 11024558
Cell Tissue Res. 1984;238(1):203-5
pubmed: 6386172
Curr Opin Endocrinol Diabetes Obes. 2011 Feb;18(1):56-60
pubmed: 21157324
Environ Toxicol Pharmacol. 2014 May;37(3):1048-59
pubmed: 24762416
Toxicol Lett. 2010 Oct 5;198(2):282-8
pubmed: 20659539
Metabolites. 2021 Jun 09;11(6):
pubmed: 34207679
Science. 1983 Aug 26;221(4613):877-9
pubmed: 6136091
Food Addit Contam. 1993 May-Jun;10(3):351-61
pubmed: 8359316
J Toxicol Sci. 2008 Aug;33(3):269-76
pubmed: 18670157
Environ Toxicol. 2011 Feb;26(1):79-85
pubmed: 19760618
Toxicol Lett. 2005 Dec 15;159(3):226-34
pubmed: 15993011
Nature. 2006 Sep 21;443(7109):289-95
pubmed: 16988703
Mol Endocrinol. 2006 Sep;20(9):2141-55
pubmed: 16613991
J Neuroendocrinol. 1998 Jan;10(1):43-9
pubmed: 9510057
Toxicol Appl Pharmacol. 2009 Oct 15;240(2):292-8
pubmed: 19591855
Peptides. 1986 Jan-Feb;7(1):155-9
pubmed: 3520509
Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:89-106
pubmed: 30044726
Neurotoxicology. 2011 Mar;32(2):277-80
pubmed: 21185327
Mol Cell Endocrinol. 2020 Dec 1;518:110997
pubmed: 32841708
Annu Rev Neurosci. 2007;30:367-98
pubmed: 17506645
Mol Cell Endocrinol. 2010 Jul 29;323(2):172-82
pubmed: 20399831