Alzheimer's Drug PBT2 Interacts with the Amyloid β 1-42 Peptide Differently than Other 8-Hydroxyquinoline Chelating Drugs.
Journal
Inorganic chemistry
ISSN: 1520-510X
Titre abrégé: Inorg Chem
Pays: United States
ID NLM: 0366543
Informations de publication
Date de publication:
19 Sep 2022
19 Sep 2022
Historique:
pubmed:
9
9
2022
medline:
21
9
2022
entrez:
8
9
2022
Statut:
ppublish
Résumé
Although Alzheimer's disease (AD) was first described over a century ago, it remains the leading cause of age-related dementia. Innumerable changes have been linked to the pathology of AD; however, there remains much discord regarding which might be the initial cause of the disease. The "amyloid cascade hypothesis" proposes that the amyloid β (Aβ) peptide is central to disease pathology, which is supported by elevated Aβ levels in the brain before the development of symptoms and correlations of amyloid burden with cognitive impairment. The "metals hypothesis" proposes a role for metal ions such as iron, copper, and zinc in the pathology of AD, which is supported by the accumulation of these metals within amyloid plaques in the brain. Metals have been shown to induce aggregation of Aβ, and metal ion chelators have been shown to reverse this reaction
Identifiants
pubmed: 36073854
doi: 10.1021/acs.inorgchem.2c01694
pmc: PMC9957665
mid: NIHMS1875837
doi:
Substances chimiques
Amyloid beta-Peptides
0
Chelating Agents
0
Ions
0
Metals
0
PBT2 compound
0
Peptide Fragments
0
Solvents
0
amyloid beta-protein (1-42)
0
Oxyquinoline
5UTX5635HP
Copper
789U1901C5
Clioquinol
7BHQ856EJ5
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
14626-14640Subventions
Organisme : NIGMS NIH HHS
ID : P30 GM133894
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103393
Pays : United States
Organisme : NCRR NIH HHS
ID : P41 RR001209
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM131781
Pays : United States
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