Aromatic Ring Fluorination Patterns Modulate Inhibitory Potency of Fluorophenylhydroxamates Complexed with Histone Deacetylase 6.

Animals Fluorine / metabolism Halogenation Histone Deacetylase 6 / chemistry Histone Deacetylase Inhibitors / chemistry Histone Deacetylases / metabolism Humans Solvents / metabolism Structure-Activity Relationship Zebrafish / metabolism

Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
20 09 2022
Historique:
pubmed: 9 9 2022
medline: 23 9 2022
entrez: 8 9 2022
Statut: ppublish

Résumé

Bavarostat (EKZ-001) is a selective inhibitor of histone deacetylase 6 (HDAC6) that contains a

Identifiants

DOI: 10.1021/acs.biochem.2c00332 PMID: 36073962 PMC: PMC9489680
pubmed: 36073962
doi: 10.1021/acs.biochem.2c00332
pmc: PMC9489680
mid: NIHMS1833898
doi:

Substances chimiques

Histone Deacetylase Inhibitors 0
Solvents 0
Fluorine 284SYP0193
Histone Deacetylase 6 EC 3.5.1.98
Histone Deacetylases EC 3.5.1.98

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

1945-1954

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS099250
Pays : United States
Organisme : NIH HHS
ID : S10 OD021527
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM049758
Pays : United States
Organisme : NIGMS NIH HHS
ID : P30 GM124165
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103393
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH111723
Pays : United States

Références

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Auteurs

Paris R Watson (PR)

Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.

Ping Bai (P)

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, United States.
ORCID: 0000-0003-4587-8426

Changning Wang (C)

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, United States.
ORCID: 0000-0002-2076-4193

Abigail D Cragin (AD)

Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
ORCID: 0000-0002-4805-9760

Jacob M Hooker (JM)

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, United States.
ORCID: 0000-0002-9394-7708

David W Christianson (DW)

Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.
ORCID: 0000-0002-0194-5212

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Aromatic Ring Fluorination Patterns Modulate...
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Halogènes › Fluor › Aromatic Ring Fluorination Patterns Modulate...
questionsmedicales.fr › Métabolisme › Halogénation › Aromatic Ring Fluorination Patterns Modulate...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › Histone deacetylases › Histone deacetylase 6 › Aromatic Ring Fluorination Patterns Modulate...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de désacétylase d'histone › Aromatic Ring Fluorination Patterns Modulate...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › Histone deacetylases › Aromatic Ring Fluorination Patterns Modulate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Aromatic Ring Fluorination Patterns Modulate...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Solvants › Aromatic Ring Fluorination Patterns Modulate...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Aromatic Ring Fluorination Patterns Modulate...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Aromatic Ring Fluorination Patterns Modulate...