Otopathologic and Computed Tomography Correlation of Internal Auditory Canal Diverticula in Otosclerosis.
Journal
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
ISSN: 1537-4505
Titre abrégé: Otol Neurotol
Pays: United States
ID NLM: 100961504
Informations de publication
Date de publication:
01 10 2022
01 10 2022
Historique:
pubmed:
9
9
2022
medline:
20
9
2022
entrez:
8
9
2022
Statut:
ppublish
Résumé
Internal auditory canal (IAC) diverticula, also known as IAC cavitary lesions or anterior cupping of the IAC, observed in otopathologic specimens and high-resolution computed tomography (CT) scans of the temporal bone are thought to be related to otosclerosis. Herein, we examined the usefulness of CT scans in identifying diverticula and determined whether IAC diverticula are associated with otosclerosis on otopathology. One hundred five consecutive specimens were identified from the National Temporal Bone Hearing and Balance Pathology Resource Registry. Inclusion criteria included the availability of histologic slides and postmortem specimen CT scans. Exclusion criteria included cases with severe postmortem changes or lesions causing bony destruction of the IAC. Ninety-seven specimens met criteria for study. Of these, 42% of the specimens were from male patients, and the average age of death was 77 years (SD = 18 yr). IAC diverticula were found in 48 specimens, of which 46% were identified in the CT scans. The mean area of the IAC diverticula was 0.34 mm 2 . The sensitivity and specificity of detecting IAC diverticula based on CT were 77% and 63%, respectively. Overall, 27% of specimens had otosclerosis. Histologic IAC diverticula were more common in specimens with otosclerosis than those without (37.5% versus 16%; p = 0.019). Cases with otosclerosis had a greater mean histologic diverticula area compared with nonotosclerosis cases (0.69 mm 2 versus 0.14 mm 2 ; p = 0.001). IAC diverticula are commonly found in otopathologic specimens with varied etiologies, but larger diverticula are more likely to be associated with otosclerosis. The sensitivity and specificity of CT scans to detect IAC diverticula are limited.
Identifiants
pubmed: 36075107
doi: 10.1097/MAO.0000000000003665
pii: 00129492-202210000-00012
pmc: PMC9771591
mid: NIHMS1825277
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e957-e962Subventions
Organisme : NIDCD NIH HHS
ID : U24 DC013983
Pays : United States
Organisme : NIDCD NIH HHS
ID : U24 DC020849
Pays : United States
Informations de copyright
Copyright © 2022, Otology & Neurotology, Inc.
Déclaration de conflit d'intérêts
J.C. has a patent pending at Grace Medical. E.K. is a scientific advisor at Desktop Metal and has a patent pending at Grace Medical. H.S. is in the surgical advisory board of MedEl and a shareholder at Rescue Hearing. M.J.McK. is the co-founder and CMO of Akouos Inc. A.Q. has a sponsored research agreement with Frequency Therapeutics, sponsored research agreement, patent pending at Grace Medical, and consulting for Alcon. The remaining authors disclose no conflicts of interest.
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