Prenatal exposure to ambient air pollution is associated with early life immune perturbations.

Child Pregnancy Female Humans Infant Air Pollutants / adverse effects Nitrogen Dioxide / adverse effects Prenatal Exposure Delayed Effects Asthma / etiology Particulate Matter / adverse effects Rhinitis, Allergic / chemically induced Environmental Exposure / adverse effects
Air pollution allergy asthma childhood environment epigenetic immune inflammation sensitization traffic urbanization

Journal

The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002

Informations de publication

Date de publication:
01 2023
Historique:
received: 18 05 2022
revised: 09 08 2022
accepted: 10 08 2022
pubmed: 9 9 2022
medline: 11 1 2023
entrez: 8 9 2022
Statut: ppublish

Résumé

Exposure to ambient air pollution has been linked to asthma, allergic rhinitis, and other inflammatory disorders, but little is known about the underlying mechanisms. We studied the potential mechanisms leading from prenatal ambient air pollution exposure to asthma and allergy in childhood. Long-term exposure to nitrogen dioxide (NO Higher prenatal air pollution exposure with NO Prenatal exposure to ambient air pollution was associated with early life immune perturbations conferring risk of allergic rhinitis and asthma. These findings suggest potential mechanisms of prenatal exposure to ambient air pollution on the developing immune system.

Sections du résumé

BACKGROUND
Exposure to ambient air pollution has been linked to asthma, allergic rhinitis, and other inflammatory disorders, but little is known about the underlying mechanisms.
OBJECTIVE
We studied the potential mechanisms leading from prenatal ambient air pollution exposure to asthma and allergy in childhood.
METHODS
Long-term exposure to nitrogen dioxide (NO
RESULTS
Higher prenatal air pollution exposure with NO
CONCLUSION
Prenatal exposure to ambient air pollution was associated with early life immune perturbations conferring risk of allergic rhinitis and asthma. These findings suggest potential mechanisms of prenatal exposure to ambient air pollution on the developing immune system.

Identifiants

DOI: 10.1016/j.jaci.2022.08.020 PMID: 36075322
pubmed: 36075322
pii: S0091-6749(22)01169-1
doi: 10.1016/j.jaci.2022.08.020
pii:
doi:

Substances chimiques

Air Pollutants 0
Nitrogen Dioxide S7G510RUBH
Particulate Matter 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

212-221

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL129735
Pays : United States

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Casper-Emil Tingskov Pedersen (CE)

Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Anders Ulrik Eliasen (AU)

Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Health Technology, Section for Bioinformatics, Technical University of Denmark, Kongens Lyngby, Denmark.

Matthias Ketzel (M)

Department of Environmental Science, Aarhus University of Copenhagen, Roskilde, Denmark.

Jørgen Brandt (J)

Department of Environmental Science, Aarhus University of Copenhagen, Roskilde, Denmark.

Steffen Loft (S)

Department of Public Health, Section of Environment and Health, University of Copenhagen, Copenhagen, Denmark; Department of Public Health, Section of Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University of Copenhagen, Roskilde, Denmark.

Lise Marie Frohn (LM)

Department of Environmental Science, Aarhus University of Copenhagen, Roskilde, Denmark.

Jibran Khan (J)

Department of Environmental Science, Aarhus University of Copenhagen, Roskilde, Denmark; Department of Public Health, Section of Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University of Copenhagen, Roskilde, Denmark.

Susanne Brix (S)

Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.

Morten A Rasmussen (MA)

Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Food Science, Roskilde, Denmark.

Jakob Stokholm (J)

Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Food Science, Roskilde, Denmark.

Bo Chawes (B)

Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Andreanne Morin (A)

Department of Human Genetics, University of Copenhagen, Copenhagen, Denmark.

Carole Ober (C)

Department of Human Genetics, University of Copenhagen, Copenhagen, Denmark.

Hans Bisgaard (H)

Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.

Marie Pedersen (M)

Department of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, Denmark.

Klaus Bønnelykke (K)

Copenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. Electronic address: kb@copsac.com.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Prenatal exposure to ambient air pollution is...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Prenatal exposure to ambient air pollution is...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prenatal exposure to ambient air pollution is...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Prenatal exposure to ambient air pollution is...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants atmosphériques › Prenatal exposure to ambient air pollution is...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Dioxyde d'azote › Prenatal exposure to ambient air pollution is...
questionsmedicales.fr › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Lésions prénatales › Effets différés de l'exposition prénatale à des facteurs de risque › Prenatal exposure to ambient air pollution is...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Prenatal exposure to ambient air pollution is...
questionsmedicales.fr › Mélanges complexes › Matière particulaire › Prenatal exposure to ambient air pollution is...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Rhinite allergique › Prenatal exposure to ambient air pollution is...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Prenatal exposure to ambient air pollution is...