Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
08 09 2022
08 09 2022
Historique:
received:
18
11
2021
accepted:
23
08
2022
entrez:
8
9
2022
pubmed:
9
9
2022
medline:
14
9
2022
Statut:
epublish
Résumé
In addition to its essential role in viral polyprotein processing, the SARS-CoV-2 3C-like protease (3CLpro) can cleave human immune signaling proteins, like NF-κB Essential Modulator (NEMO) and deregulate the host immune response. Here, in vitro assays show that SARS-CoV-2 3CLpro cleaves NEMO with fine-tuned efficiency. Analysis of the 2.50 Å resolution crystal structure of 3CLpro C145S bound to NEMO
Identifiants
pubmed: 36075915
doi: 10.1038/s41467-022-32922-9
pii: 10.1038/s41467-022-32922-9
pmc: PMC9453703
doi:
Substances chimiques
Antiviral Agents
0
Proteins
0
Peptide Hydrolases
EC 3.4.-
Cysteine Endopeptidases
EC 3.4.22.-
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
5285Subventions
Organisme : NIGMS NIH HHS
ID : P30 GM133894
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG053303
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© 2022. The Author(s).
Références
Viruses. 2010 Aug;2(8):1804-20
pubmed: 21994708
Virology. 2016 Jul;494:225-35
pubmed: 27128350
ACS Catal. 2020;10:12544-12554
pubmed: 34192089
IUCrJ. 2021 Oct 05;8(Pt 6):973-979
pubmed: 34804549
Elife. 2020 Jul 07;9:
pubmed: 32633718
Nat Commun. 2020 Jun 24;11(1):3202
pubmed: 32581217
J Virol. 2008 Mar;82(5):2515-27
pubmed: 18094151
J Virol. 2008 Sep;82(17):8647-55
pubmed: 18562531
Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8259-63
pubmed: 7667278
Bioinformatics. 2009 Oct 15;25(20):2745-6
pubmed: 19717576
Proteins. 2011 Sep;79(9):2671-83
pubmed: 21735484
Biochem J. 2020 Mar 13;477(5):1009-1019
pubmed: 32083638
IUCrJ. 2021 Feb 09;8(Pt 2):238-256
pubmed: 33708401
Nature. 2020 Oct;586(7830):509-515
pubmed: 32967005
Acta Crystallogr D Biol Crystallogr. 1997 May 1;53(Pt 3):240-55
pubmed: 15299926
Orphanet J Rare Dis. 2013 Feb 13;8:25
pubmed: 23406512
J Synchrotron Radiat. 2002 Nov 1;9(Pt 6):401-6
pubmed: 12409628
Chemphyschem. 2018 Apr 5;19(7):873-879
pubmed: 29316128
Virulence. 2020 Dec;11(1):486-488
pubmed: 32434416
Sci Rep. 2022 Jul 16;12(1):12197
pubmed: 35842458
Nat Commun. 2016 Sep 02;7:12629
pubmed: 27586688
BMC Struct Biol. 2012 Aug 02;12:18
pubmed: 22857400
Proc Natl Acad Sci U S A. 2016 Nov 15;113(46):12997-13002
pubmed: 27799534
Acta Crystallogr F Struct Biol Commun. 2020 Oct 1;76(Pt 10):483-487
pubmed: 33006576
J Comput Chem. 2010 Jan 30;31(2):455-61
pubmed: 19499576
Proteins. 2007 Sep 1;68(4):813-23
pubmed: 17554779
Chem Sci. 2018 Mar 20;9(15):3710-3715
pubmed: 29780502
Hum Mol Genet. 2004 Aug 15;13(16):1763-73
pubmed: 15229184
Elife. 2020 Apr 02;9:
pubmed: 32228860
Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):
pubmed: 34083352
N Engl J Med. 2020 Jun 4;382(23):2268-2270
pubmed: 32294339
Cell Rep. 2020 Oct 6;33(1):108234
pubmed: 32979938
Genome Res. 2004 Jun;14(6):1188-90
pubmed: 15173120
EMBO J. 2003 Jun 2;22(11):2552-60
pubmed: 12773372
Science. 2020 Apr 24;368(6489):409-412
pubmed: 32198291
Nat Rev Microbiol. 2009 Jun;7(6):439-50
pubmed: 19430490
J Chem Theory Comput. 2021 Mar 9;17(3):1931-1943
pubmed: 33562962
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
pubmed: 15572765
Cell Chem Biol. 2020 Nov 19;27(11):1441-1451.e7
pubmed: 32726587
Proc Natl Acad Sci U S A. 2020 Nov 17;117(46):28939-28949
pubmed: 33106404
Acta Crystallogr D Struct Biol. 2019 Oct 1;75(Pt 10):861-877
pubmed: 31588918
Nat Commun. 2020 Nov 18;11(1):5877
pubmed: 33208735
Nucleic Acids Res. 2019 Jul 2;47(W1):W636-W641
pubmed: 30976793
J Chem Inf Model. 2018 Aug 27;58(8):1697-1706
pubmed: 29989806
PLoS One. 2015 Dec 14;10(12):e0144865
pubmed: 26658006
J Phys Chem Lett. 2015 Dec 17;6(24):5034-9
pubmed: 26623658
J Biol Chem. 2017 Sep 22;292(38):15838-15848
pubmed: 28784664
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
N Engl J Med. 2022 Apr 14;386(15):1397-1408
pubmed: 35172054
J Chem Inf Model. 2014 Jun 23;54(6):1717-36
pubmed: 24708446
Nat Neurosci. 2021 Nov;24(11):1522-1533
pubmed: 34675436
Biophys J. 1999 Mar;76(3):1367-76
pubmed: 10049319
Emerg Microbes Infect. 2021 Dec;10(1):178-195
pubmed: 33372854
J Virol. 2015 Dec 09;90(4):2090-101
pubmed: 26656704
Nature. 2020 Jun;582(7811):289-293
pubmed: 32272481
Viruses. 2019 Dec 30;12(1):
pubmed: 31905881
J Chem Inf Model. 2020 Dec 28;60(12):5832-5852
pubmed: 33326239
ACS Comb Sci. 2020 Jun 8;22(6):297-305
pubmed: 32402186
Sci Rep. 2019 Feb 27;9(1):2950
pubmed: 30814588
J Chem Theory Comput. 2014 Nov 11;10(11):4801-12
pubmed: 26584367
Adv Exp Med Biol. 2016;922:119-135
pubmed: 27553239
Mol Cell. 2008 Jun 6;30(5):620-31
pubmed: 18538660
Cold Spring Harb Perspect Med. 2012 Apr;2(4):a007161
pubmed: 22474613
Mol Biol Evol. 2021 Jan 23;38(2):702-715
pubmed: 32941612
Signal Transduct Target Ther. 2017;2:
pubmed: 29158945
J Exp Med. 2015 Sep 21;212(10):1529-49
pubmed: 26347470
J Biol Chem. 2020 Dec 11;295(50):17365-17373
pubmed: 33060199
J Struct Biol. 2002 Jan-Feb;137(1-2):54-64
pubmed: 12064933
Structure. 2008 May;16(5):798-808
pubmed: 18462684
Proteomics. 2021 Jan;21(2):e2000246
pubmed: 33111431