Identification of A
Adenosine receptors
Colorectal cancer
Drug screening
Fluorescent ligands
GPCRs
Tumor microenvironment
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
13
04
2022
revised:
29
06
2022
accepted:
11
07
2022
entrez:
9
9
2022
pubmed:
10
9
2022
medline:
14
9
2022
Statut:
ppublish
Résumé
G-protein coupled receptors (GPCRs) have been largely targeted in a wide range of diseases, but few therapies have been directed against GPCRs in the field of cancer, partly because of the lack of effective target identification strategies. Here, using colorectal cancer (CRC) as a model, we explored the gene expression of a panel of GPCRs in tumor and stromal cells, identifying specific gene sets defining each cellular compartment. We selected the adenosine receptor 2B (A
Identifiants
pubmed: 36076535
pii: S0753-3322(22)00797-1
doi: 10.1016/j.biopha.2022.113408
pii:
doi:
Substances chimiques
Fluorescent Dyes
0
Ligands
0
Receptors, G-Protein-Coupled
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113408Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest María Majellaro is Chief Scientific Officer of Celtarys Research SL.