Downstream Effects of Mutations in

Amyotrophic Lateral Sclerosis / genetics DNA-Binding Proteins / genetics Gene Expression Humans Induced Pluripotent Stem Cells / metabolism Motor Neurons / metabolism Mutation Neurodegenerative Diseases / metabolism RNA / metabolism Superoxide Dismutase-1 / genetics
RNA sequencing (RNA-Seq) amyotrophic lateral sclerosis (ALS) differentially expressed genes (DEG) human induced pluripotent stem cells (iPSC) motor neurons (MN) protein-protein interaction (PPI)

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
25 Aug 2022
Historique:
received: 15 07 2022
revised: 19 08 2022
accepted: 22 08 2022
entrez: 9 9 2022
pubmed: 10 9 2022
medline: 14 9 2022
Statut: epublish

Résumé

Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease marked by death of motor neurons (MNs) present in the spinal cord, brain stem and motor cortex. Despite extensive research, the reason for neurodegeneration is still not understood. To generate novel hypotheses of putative underlying molecular mechanisms, we used human induced pluripotent stem cell (hiPSCs)-derived motor neurons (MNs) from

Identifiants

DOI: 10.3390/ijms23179652 PMID: 36077049 PMC: PMC9456253
pubmed: 36077049
pii: ijms23179652
doi: 10.3390/ijms23179652
pmc: PMC9456253
pii:
doi:

Substances chimiques

DNA-Binding Proteins 0
SOD1 protein, human 0
TARDBP protein, human 0
RNA 63231-63-0
Superoxide Dismutase-1 EC 1.15.1.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Références

Brain. 2005 Jul;128(Pt 7):1686-706
pubmed: 15872021
G3 (Bethesda). 2013 Apr 9;3(4):695-708
pubmed: 23550139
Genomics. 2020 Mar;112(2):1290-1299
pubmed: 31377428
Sci Rep. 2017 Aug 30;7(1):10046
pubmed: 28855684
Bioinformatics. 2011 Feb 1;27(3):431-2
pubmed: 21149340
Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7701-E7709
pubmed: 27849576
Neurotherapeutics. 2015 Apr;12(2):340-51
pubmed: 25689976
Elife. 2018 Jul 13;7:
pubmed: 30003873
Stem Cells Transl Med. 2012 May;1(5):396-402
pubmed: 23197818
Mech Ageing Dev. 2017 Jan;161(Pt A):163-176
pubmed: 27663141
BMC Syst Biol. 2014;8 Suppl 4:S11
pubmed: 25521941
Bioinformatics. 2009 Apr 15;25(8):1091-3
pubmed: 19237447
Neurosci Lett. 2019 Sep 25;710:132933
pubmed: 28669745
PLoS One. 2013;8(1):e53575
pubmed: 23301088
Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4696-4705
pubmed: 30770445
Essays Biochem. 2020 Oct 26;64(5):847-861
pubmed: 33078197
PLoS One. 2017 Nov 10;12(11):e0187813
pubmed: 29125873
Hum Mol Genet. 2019 Sep 1;28(17):2835-2850
pubmed: 31108504
Nat Protoc. 2009;4(1):44-57
pubmed: 19131956
Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):E1121-9
pubmed: 24616503
Hum Mol Genet. 2019 Apr 01;28(15):2459-2476
pubmed: 31067307
Cells. 2022 Apr 06;11(7):
pubmed: 35406813
Neuron. 2013 Aug 7;79(3):416-38
pubmed: 23931993
Sci Rep. 2016 Dec 16;6:39297
pubmed: 27982123
Traffic. 2013 Jan;14(1):2-14
pubmed: 22913533
Nat Rev Neurosci. 2013 Apr;14(4):248-64
pubmed: 23463272
N Engl J Med. 2017 Jul 13;377(2):162-172
pubmed: 28700839
Science. 1994 Jun 17;264(5166):1772-5
pubmed: 8209258
Adv Neurobiol. 2018;20:283-301
pubmed: 29916024
Bioinformatics. 2013 Mar 1;29(5):661-3
pubmed: 23325622
J Neurol Sci. 1996 Jul;139(1):15-20
pubmed: 8836967
Nucleic Acids Res. 2016 Feb 29;44(4):e33
pubmed: 26464439
Int J Mol Sci. 2021 Sep 02;22(17):
pubmed: 34502460
Sci Data. 2018 Nov 13;5:180241
pubmed: 30422121
RNA Biol. 2010 Jul-Aug;7(4):420-9
pubmed: 20639693
Neural Regen Res. 2021 Oct;16(10):1950-1957
pubmed: 33642365
Nat Neurosci. 2011 Apr;14(4):452-8
pubmed: 21358640
Acta Neuropathol Commun. 2020 Jul 24;8(1):116
pubmed: 32709255
Sci Rep. 2017 Mar 16;7:44500
pubmed: 28300211
Nat Neurosci. 2011 Apr;14(4):459-68
pubmed: 21358643
PLoS One. 2013;8(3):e59252
pubmed: 23533608
Lancet Neurol. 2018 Jan;17(1):94-102
pubmed: 29154141
Trends Genet. 2018 Jun;34(6):404-423
pubmed: 29605155
Wiley Interdiscip Rev RNA. 2013 Sep-Oct;4(5):581-92
pubmed: 23776162
Neurobiol Dis. 2018 Jul;115:167-181
pubmed: 29630989
Neuroscience. 2011 Apr 14;179:233-43
pubmed: 21303685
Neurochem Int. 2020 Nov;140:104814
pubmed: 32758586
Brain Res. 2012 Jun 26;1462:3-15
pubmed: 22444279
Trends Mol Med. 2011 Nov;17(11):659-67
pubmed: 21783422
Hum Mol Genet. 2013 Oct 15;22(20):4136-47
pubmed: 23740936
Hum Mol Genet. 2013 Dec 1;22(23):4706-19
pubmed: 23827948
J Clin Invest. 2015 May;125(5):1767-79
pubmed: 25932674
Nat Rev Neurol. 2012 Sep;8(9):518-30
pubmed: 22890216
Nucleic Acids Res. 2016 Jan 4;44(D1):D457-62
pubmed: 26476454
PLoS One. 2012;7(8):e43120
pubmed: 22900096
Front Genet. 2019 Jan 22;9:712
pubmed: 30723494
Hum Mol Genet. 2014 Mar 15;23(6):1413-24
pubmed: 24154542
Hum Mol Genet. 2015 Mar 15;24(6):1741-54
pubmed: 25432537
Stem Cell Reports. 2018 Dec 11;11(6):1565-1578
pubmed: 30540963
Nucleic Acids Res. 2019 Jan 8;47(D1):D607-D613
pubmed: 30476243
Nat Methods. 2008 Jul;5(7):621-8
pubmed: 18516045
Nat Rev Neurol. 2011 Nov;7(11):616-30
pubmed: 22051914
Stem Cells. 2016 Jun;34(6):1563-75
pubmed: 26946488
J Neurochem. 2016 Aug;138 Suppl 1:95-111
pubmed: 27015757
PLoS One. 2014 Jan 30;9(1):e87255
pubmed: 24498056
Front Mol Neurosci. 2017 Mar 23;10:85
pubmed: 28386218
Biochem Pharmacol. 2018 Nov;157:217-226
pubmed: 30076846
EMBO Mol Med. 2013 Feb;5(2):221-34
pubmed: 23255347
Neurobiol Dis. 2017 Sep;105:283-299
pubmed: 28235672
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7
pubmed: 27141961
Acta Neuropathol. 2020 Nov;140(5):695-713
pubmed: 32803350
Acta Neuropathol. 2012 Feb;123(2):157-71
pubmed: 22143516
Nature. 2016 Nov 10;539(7628):197-206
pubmed: 27830784
Front Neurosci. 2017 May 31;11:312
pubmed: 28620277
Brain. 1996 Aug;119 ( Pt 4):1153-72
pubmed: 8813280
Ageing Res Rev. 2018 Jul;44:8-21
pubmed: 29580918
Nat Commun. 2019 Apr 3;10(1):1523
pubmed: 30944313
BMC Bioinformatics. 2003 Jan 13;4:2
pubmed: 12525261
Nat Neurosci. 2009 May;12(5):627-36
pubmed: 19330001
Nucleic Acids Res. 2019 Jul 2;47(W1):W234-W241
pubmed: 30931480
Int J Mol Sci. 2020 Sep 21;21(18):
pubmed: 32967368
Cell. 2010 May 14;141(4):632-44
pubmed: 20434207
J Neurol Sci. 2010 Jan 15;288(1-2):1-12
pubmed: 19840884
Exp Neurol. 2005 Feb;191(2):331-6
pubmed: 15649489
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4697-702
pubmed: 23401527
Nat Commun. 2018 Jan 23;9(1):335
pubmed: 29362359
Stem Cell Reports. 2021 Dec 14;16(12):3020-3035
pubmed: 34767750
Biochim Biophys Acta. 2006 Nov-Dec;1762(11-12):1051-67
pubmed: 16713195
Front Cell Neurosci. 2013 Dec 17;7:259
pubmed: 24381542
Cell Stem Cell. 2013 Mar 7;12(3):354-67
pubmed: 23472874
Brain. 2010 Aug;133(Pt 8):2313-30
pubmed: 20826431
Comput Biol Chem. 2019 Feb;78:431-439
pubmed: 30606694
Nucleic Acids Res. 2006 Jun 06;34(10):3150-60
pubmed: 16757580
Nucleic Acids Res. 2022 Jan 7;50(D1):D165-D173
pubmed: 34850907
Nat Rev Neurosci. 2012 Apr 13;13(5):308-24
pubmed: 22498899
J Biol Chem. 2011 Jan 14;286(2):1204-15
pubmed: 21051541

Auteurs

Banaja P Dash (BP)

Translational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, 18147 Rostock, Germany.
ORCID: 0000-0003-4580-139X

Axel Freischmidt (A)

Department of Neurology, Ulm University, 89081 Ulm, Germany.

Jochen H Weishaupt (JH)

Division of Neurodegeneration, Department of Neurology, Mannheim Center for Translational Neurosciences, Medical Faculty Mannheim, Heidelberg University, 68167 Mannheim, Germany.

Andreas Hermann (A)

Translational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center Rostock, 18147 Rostock, Germany.
Center for Transdisciplinary Neurosciences Rostock, University Medical Center Rostock, 18147 Rostock, Germany.
Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) Rostock/Greifswald, 18147 Rostock, Germany.
ORCID: 0000-0002-7364-7791

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Downstream Effects of Mutations in
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › Downstream Effects of Mutations in
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Downstream Effects of Mutations in
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Downstream Effects of Mutations in
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Downstream Effects of Mutations in
questionsmedicales.fr › Cellules › Neurones › Neurones efférents › Motoneurones › Downstream Effects of Mutations in
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Downstream Effects of Mutations in
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Downstream Effects of Mutations in
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Downstream Effects of Mutations in
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › Superoxide dismutase-1 › Downstream Effects of Mutations in