How Can We Improve the Vaccination Response in Older People? Part II: Targeting Immunosenescence of Adaptive Immunity Cells.
B cells
T cells
adaptive immunity
aging
immunosenescence
vaccines
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
29 Aug 2022
29 Aug 2022
Historique:
received:
05
08
2022
revised:
22
08
2022
accepted:
24
08
2022
entrez:
9
9
2022
pubmed:
10
9
2022
medline:
14
9
2022
Statut:
epublish
Résumé
The number of people that are 65 years old or older has been increasing due to the improvement in medicine and public health. However, this trend is not accompanied by an increase in quality of life, and this population is vulnerable to most illnesses, especially to infectious diseases. Vaccination is the best strategy to prevent this fact, but older people present a less efficient response, as their immune system is weaker due mainly to a phenomenon known as immunosenescence. The adaptive immune system is constituted by two types of lymphocytes, T and B cells, and the function and fitness of these cell populations are affected during ageing. Here, we review the impact of ageing on T and B cells and discuss the approaches that have been described or proposed to modulate and reverse the decline of the ageing adaptive immune system.
Identifiants
pubmed: 36077216
pii: ijms23179797
doi: 10.3390/ijms23179797
pmc: PMC9456031
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Spanish Association against Cancer (AECC)
ID : PROYE16001ESCO
Organisme : Instituto de Salud Carlos III (ISCIII)
ID : FEDER project grants (FIS PI17/02119, FIS PI20/00010, COV20/00000, and TRANSPOCART ICI19/00069)
Organisme : Biomedicine Project grant from the Department of Health of the Government of Navarre
ID : BMED 050-2019
Organisme : Department of Industry, Government of Navarre
ID : Strategic projects from the Department of Industry, Government of Navarre (AGATA, Ref 0011-1411-2020-000013; LINTERNA, Ref. 0011-1411-2020-000033; DESCARTHES, 0011-1411-2019-000058)
Organisme : Ministerio de Ciencia e Innovación
ID : PID2019-108989RB-I00, PLEC2021-008094 MCIN/AEI/10.13039/ 501100011033
Organisme : European Project Horizon 2020 Improved Vaccination for Older Adults
ID : ISOLDA; Grant agreement ID: 848166
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