T-Type Calcium Channels: A Mixed Blessing.
T-type Ca2+ channel
T-type calcium channel blocker
bortezomib
cancer therapy
cardiotoxicity
carfilzomib
mibefradil
peripheral neuropathy
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 Aug 2022
31 Aug 2022
Historique:
received:
03
08
2022
revised:
26
08
2022
accepted:
29
08
2022
entrez:
9
9
2022
pubmed:
10
9
2022
medline:
14
9
2022
Statut:
epublish
Résumé
The role of T-type calcium channels is well established in excitable cells, where they preside over action potential generation, automaticity, and firing. They also contribute to intracellular calcium signaling, cell cycle progression, and cell fate; and, in this sense, they emerge as key regulators also in non-excitable cells. In particular, their expression may be considered a prognostic factor in cancer. Almost all cancer cells express T-type calcium channels to the point that it has been considered a pharmacological target; but, as the drugs used to reduce their expression are not completely selective, several complications develop, especially within the heart. T-type calcium channels are also involved in a specific side effect of several anticancer agents, that act on microtubule transport, increase the expression of the channel, and, thus, the excitability of sensory neurons, and make the patient more sensitive to pain. This review puts into context the relevance of T-type calcium channels in cancer and in chemotherapy side effects, considering also the cardiotoxicity induced by new classes of antineoplastic molecules.
Identifiants
pubmed: 36077291
pii: ijms23179894
doi: 10.3390/ijms23179894
pmc: PMC9456242
pii:
doi:
Substances chimiques
Calcium Channel Blockers
0
Calcium Channels, T-Type
0
Mibefradil
27B90X776A
Calcium
SY7Q814VUP
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Milano-Bicocca
ID : 2021-ATE-0069
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