Unbalanced Expression of Glutathione Peroxidase 4 and Arachidonate 15-Lipoxygenase Affects Acrosome Reaction and In Vitro Fertilization.

Acrosome / metabolism Acrosome Reaction Animals Arachidonate 15-Lipoxygenase / genetics Exocytosis Fertilization in Vitro Male Mice Phospholipid Hydroperoxide Glutathione Peroxidase Semen Spermatozoa / metabolism
eicosanoids fertility lipid peroxidation redox homeostasis sperm

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
31 Aug 2022
Historique:
received: 11 07 2022
revised: 19 08 2022
accepted: 27 08 2022
entrez: 9 9 2022
pubmed: 10 9 2022
medline: 14 9 2022
Statut: epublish

Résumé

Glutathione peroxidase 4 (Gpx4) and arachidonic acid 15 lipoxygenase (Alox15) are counterplayers in oxidative lipid metabolism and both enzymes have been implicated in spermatogenesis. However, the roles of the two proteins in acrosomal exocytosis have not been explored in detail. Here we characterized Gpx4 distribution in mouse sperm and detected the enzyme not only in the midpiece of the resting sperm but also at the anterior region of the head, where the acrosome is localized. During sperm capacitation, Gpx4 translocated to the post-acrosomal compartment. Sperm from Gpx4

Identifiants

DOI: 10.3390/ijms23179907 PMID: 36077303 PMC: PMC9456195
pubmed: 36077303
pii: ijms23179907
doi: 10.3390/ijms23179907
pmc: PMC9456195
pii:
doi:

Substances chimiques

Phospholipid Hydroperoxide Glutathione Peroxidase EC 1.11.1.12
Arachidonate 15-Lipoxygenase EC 1.13.11.33

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : Ku 961/13-1
Organisme : Deutsche Forschungsgemeinschaft
ID : Ku 961/14-1

Références

Andrologia. 2021 Feb;53(1):e13577
pubmed: 32271474
Hum Reprod Update. 2004 Sep-Oct;10(5):387-99
pubmed: 15218008
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3100-5
pubmed: 9501222
Biol Reprod. 2003 Sep;69(3):885-95
pubmed: 12724282
Reproduction. 2005 Aug;130(2):213-22
pubmed: 16049159
Biochim Biophys Acta. 1979 Feb 26;572(2):293-7
pubmed: 106892
Hum Reprod. 2013 Apr;28(4):852-65
pubmed: 23355646
J Clin Invest. 2010 Apr;120(4):984-94
pubmed: 20364096
Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep;1863(9):1095-1107
pubmed: 29883798
J Biol Chem. 2015 Jun 5;290(23):14668-78
pubmed: 25922076
J Biol Chem. 2016 Nov 4;291(45):23578-23588
pubmed: 27634046
Andrologia. 2006 Aug;38(4):152-7
pubmed: 16872467
Cell. 1997 May 16;89(4):597-606
pubmed: 9160751
Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Jul;1862(7):666-675
pubmed: 28400162
Gene. 2013 Sep 10;526(2):75-9
pubmed: 23747402
Hum Reprod. 2011 Dec;26(12):3264-73
pubmed: 21940394
Biochim Biophys Acta. 1986 Dec 22;864(3-4):471-95
pubmed: 3098292
Adv Enzymol Relat Areas Mol Biol. 1986;58:191-272
pubmed: 3087141
Oxid Med Cell Longev. 2020 Feb 5;2020:7038124
pubmed: 32089776
Cell Tissue Res. 2010 Jun;340(3):569-81
pubmed: 20449608
Can J Biochem Physiol. 1959 Aug;37(8):911-7
pubmed: 13671378
Biochim Biophys Acta. 1990 Mar 12;1043(1):12-8
pubmed: 2106918
Front Cell Dev Biol. 2019 Sep 18;7:195
pubmed: 31620437
Mol Hum Reprod. 1997 Mar;3(3):195-202
pubmed: 9237245
J Biol Chem. 1996 Sep 27;271(39):24055-62
pubmed: 8798642
J Cell Physiol. 2012 Apr;227(4):1420-7
pubmed: 21618532
Science. 1999 Aug 27;285(5432):1393-6
pubmed: 10464096
Front Cell Dev Biol. 2018 Jul 27;6:72
pubmed: 30105226
Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):217-21
pubmed: 1729692
J Biol Chem. 2009 Nov 20;284(47):32522-32
pubmed: 19783653
J Biol Chem. 1998 Nov 27;273(48):32023-9
pubmed: 9822675
Free Radic Biol Med. 2003 Feb 15;34(4):496-502
pubmed: 12566075
Immunol Lett. 2010 Oct 30;133(2):85-93
pubmed: 20691731
Antioxid Redox Signal. 2015 Feb 1;22(4):281-93
pubmed: 25313597
Biol Reprod. 2018 Jul 1;99(1):127-133
pubmed: 29462288
J Reprod Immunol. 2009 Dec;83(1-2):50-5
pubmed: 19850354
Anal Bioanal Chem. 2015 Apr;407(10):2675-83
pubmed: 25577350
Biochemistry. 2007 Aug 7;46(31):9041-9
pubmed: 17630701
J Trace Elem Med Biol. 1997 Jun;11(2):83-91
pubmed: 9285888
Gene. 2015 Nov 15;573(1):1-32
pubmed: 26216303
Biol Reprod. 2016 Sep;95(3):50
pubmed: 27417908
Biochim Biophys Acta. 2013 May;1830(5):3289-303
pubmed: 23201771
Reprod Biol Endocrinol. 2004 Nov 09;2:75
pubmed: 15535886
Mol Hum Reprod. 1999 Nov;5(11):1017-26
pubmed: 10541563
Free Radic Biol Med. 2002 Jul 15;33(2):154-72
pubmed: 12106812
J Biol Chem. 1996 Mar 1;271(9):4653-8
pubmed: 8617728
Theriogenology. 2020 Jul 1;150:388-395
pubmed: 32093962
J Biol Chem. 1992 Mar 25;267(9):6142-6
pubmed: 1556123
Prostaglandins. 1992 Dec;44(6):497-507
pubmed: 1475374
Reprod Med Biol. 2013 Sep 27;13(2):71-79
pubmed: 29699151
Antioxidants (Basel). 2020 Feb 04;9(2):
pubmed: 32033035
Development. 2019 Aug 2;146(15):
pubmed: 31375552
Biochem Soc Trans. 2014 Dec;42(6):1740-3
pubmed: 25399599
Spermatogenesis. 2014 Dec 31;4(2):e979108
pubmed: 26413390
Mol Reprod Dev. 2017 Oct;84(10):1039-1052
pubmed: 28749007
Biol Chem. 2007 Oct;388(10):987-95
pubmed: 17937612
Biochem Biophys Res Commun. 2003 May 30;305(2):278-86
pubmed: 12745070
Antioxidants (Basel). 2020 Jan 27;9(2):
pubmed: 32012712
Mol Cell Endocrinol. 2020 Dec 1;518:110951
pubmed: 32712386
Cell Tissue Res. 2016 Jan;363(1):147-157
pubmed: 26271197
Cell Signal. 2013 Dec;25(12):2548-57
pubmed: 23993959
Mol Hum Reprod. 2014 Nov;20(11):1054-66
pubmed: 25180269
Prog Lipid Res. 2019 Jan;73:28-45
pubmed: 30472260
Int J Biochem. 1989;21(1):7-13
pubmed: 2502446
Redox Biol. 2015 Dec;6:51-72
pubmed: 26184557
Biol Reprod. 2018 Jun 1;98(6):784-794
pubmed: 29546268
Antioxidants (Basel). 2019 Aug 02;8(8):
pubmed: 31382427
Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4892-6
pubmed: 21383182
Development. 1995 Apr;121(4):1139-50
pubmed: 7538069
Reproduction. 2020 Apr;159(4):R189-R201
pubmed: 31846434
Biochim Biophys Acta. 1995 Jan 3;1254(1):112-6
pubmed: 7811740
Clin Rev Allergy Immunol. 1999 Spring-Summer;17(1-2):71-89
pubmed: 10436860
EMBO J. 1994 Mar 15;13(6):1476-81
pubmed: 8137829
Cell Tissue Res. 2012 Sep;349(3):881-95
pubmed: 22729485
Front Cell Dev Biol. 2019 Dec 18;7:341
pubmed: 31921853
BMC Genomics. 2014 Oct 14;15:897
pubmed: 25315394
Biol Reprod. 2014 Nov;91(5):109
pubmed: 25232017
Int J Androl. 2002 Apr;25(2):72-83
pubmed: 11903656
Rev Reprod. 1997 Sep;2(3):165-74
pubmed: 9414480
Anal Bioanal Chem. 2015 Feb;407(5):1403-14
pubmed: 25542569
Biochim Biophys Acta. 2000 Nov 10;1469(3):197-235
pubmed: 11063883
Nature. 1994 Nov 10;372(6502):179-82
pubmed: 7969451
Biofactors. 2001;14(1-4):213-22
pubmed: 11568459
J Clin Invest. 1991 Apr;87(4):1139-45
pubmed: 2010530
J Cell Sci. 1995 May;108 ( Pt 5):2017-25
pubmed: 7544800
Lab Anim (NY). 2015 Sep;44(9):346-9
pubmed: 26300094
FASEB J. 1999 Jan;13(1):143-54
pubmed: 9872939
Andrologia. 2020 Mar;52(2):e13459
pubmed: 31724759

Auteurs

Mariana Soria-Tiedemann (M)

Department of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, D-10117 Berlin, Germany.

Geert Michel (G)

Department of Transgenic Technologies, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Lindenberger Weg 80, D-13125 Berlin, Germany.

Iris Urban (I)

Department of Transgenic Technologies, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Lindenberger Weg 80, D-13125 Berlin, Germany.

Maceler Aldrovandi (M)

Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.
Helmholtz Zentrum München, Institute of Metabolism and Cell Death, Ingolstädter Landstr. 1, D-85764 Neuherberg, Germany.

Valerie B O'Donnell (VB)

Systems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.

Sabine Stehling (S)

Department of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, D-10117 Berlin, Germany.

Hartmut Kuhn (H)

Department of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, D-10117 Berlin, Germany.
ORCID: 0000-0001-8142-3192

Astrid Borchert (A)

Department of Biochemistry, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Charitéplatz 1, D-10117 Berlin, Germany.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Cellules › Cellules germinales › Spermatozoïdes › Tête du spermatozoïde › Acrosome › Unbalanced Expression of Glutathione...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Fécondation › Interaction sperme-ovule › Réaction acrosomique › Unbalanced Expression of Glutathione...
questionsmedicales.fr › Eucaryotes › Animaux › Unbalanced Expression of Glutathione...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Lipoxygénases › Arachidonate lipoxygenases › Arachidonate 15-lipoxygenase › Unbalanced Expression of Glutathione...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Exocytose › Unbalanced Expression of Glutathione...
questionsmedicales.fr › Techniques d'investigation › Techniques de reproduction › Techniques de reproduction assistée › Fécondation in vitro › Unbalanced Expression of Glutathione...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Unbalanced Expression of Glutathione...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Sélénoprotéines › Glutathione peroxidase › Phospholipid hydroperoxide glutathione peroxidase › Unbalanced Expression of Glutathione...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Sperme › Unbalanced Expression of Glutathione...
questionsmedicales.fr › Cellules › Cellules germinales › Spermatozoïdes › Unbalanced Expression of Glutathione...