Sodium-Calcium Exchanger 2: A Pivotal Role in Oxaliplatin Induced Peripheral Neurotoxicity and Axonal Damage?

NCX2 axonal damage axonal hyperexcitability chemotherapy induced peripheral neuropathy chemotherapy-induced peripheral neurotoxicity immunofluorescence immunohistochemistry nerve excitability testing neuropathology neuroprotection voltage-operated ion channels

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
02 Sep 2022
Historique:
received: 10 08 2022
revised: 26 08 2022
accepted: 29 08 2022
entrez: 9 9 2022
pubmed: 10 9 2022
medline: 14 9 2022
Statut: epublish

Résumé

Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN) is a frequent adverse event of colorectal cancer treatment. OIPN encompasses a chronic and an acute syndrome. The latter consists of transient axonal hyperexcitability, due to unbalance in Na

Identifiants

pubmed: 36077454
pii: ijms231710063
doi: 10.3390/ijms231710063
pmc: PMC9456447
pii:
doi:

Substances chimiques

Slc8a2 protein, mouse 0
Slc8a2 protein, rat 0
Sodium-Calcium Exchanger 0
Oxaliplatin 04ZR38536J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NCI NIH HHS
ID : R01 CA268125
Pays : United States
Organisme : UNIMIB
ID : 2021-ATESP-0042
Organisme : UNIMIB
ID : 2020-ATESP-0110
Organisme : MUR/PRIN
ID : 2017ZFJCS3

Références

Am J Physiol Cell Physiol. 2005 Jun;288(6):C1374-80
pubmed: 15703202
Clin Neurophysiol. 2018 Mar;129(3):694-706
pubmed: 29233604
Expert Opin Drug Metab Toxicol. 2019 Jun;15(6):487-497
pubmed: 31116618
J Neurochem. 1996 Feb;66(2):493-500
pubmed: 8592118
Proc Nutr Soc. 1990 Feb;49(1):57-75
pubmed: 2190228
Clin Cancer Res. 2000 Apr;6(4):1205-18
pubmed: 10778943
J Peripher Nerv Syst. 2019 Oct;24 Suppl 2:S63-S73
pubmed: 31647152
Neuron. 2008 Sep 25;59(6):861-72
pubmed: 18817727
Brain. 2000 Dec;123 Pt 12:2542-51
pubmed: 11099455
Cancer. 2013 Jan 15;119(2):438-44
pubmed: 22786764
Brain Res. 1995 Oct 2;694(1-2):158-66
pubmed: 8974640
Clin Colorectal Cancer. 2002 May;2(1):54-8
pubmed: 12453338
Front Genet. 2012 Oct 02;3:200
pubmed: 23060904
Cardiovasc Drug Rev. 2004 Winter;22(4):334-47
pubmed: 15592578
Cancer Chemother Pharmacol. 2012 Dec;70(6):899-902
pubmed: 23108696
J Pharmacol Exp Ther. 2001 Jul;298(1):249-56
pubmed: 11408549
Exp Neurol. 2020 Mar;325:113154
pubmed: 31837318
Exp Neurol. 2011 Jun;229(2):353-7
pubmed: 21385581
J Med Chem. 2015 Sep 24;58(18):7093-118
pubmed: 25927480
Cell Calcium. 2016 Jul;60(1):25-31
pubmed: 27166151
Support Care Cancer. 2018 Sep;26(9):3143-3151
pubmed: 29594485
Ann Oncol. 2012 Dec;23(12):3116-3122
pubmed: 22865779
J Neurol Neurosurg Psychiatry. 2014 Apr;85(4):392-8
pubmed: 23813745
J Neurophysiol. 2001 May;85(5):2293-7
pubmed: 11353042
Brain Sci. 2021 Jan 22;11(2):
pubmed: 33499072
J Peripher Nerv Syst. 2019 Dec;24(4):298-303
pubmed: 31486252
Muscle Nerve. 2012 Mar;45(3):403-11
pubmed: 22334175
Neurotoxicology. 2009 Jul;30(4):677-85
pubmed: 19422847
Cancer. 2013 Oct 1;119(19):3570-7
pubmed: 23821303
J Peripher Nerv Syst. 2009 Mar;14(1):45-53
pubmed: 19335539
Biochem Biophys Res Commun. 2000 Dec 20;279(2):354-7
pubmed: 11118291
Mol Pharmacol. 2015 Jul;88(1):141-50
pubmed: 25848093
J Peripher Nerv Syst. 2019 Oct;24 Suppl 2:S6-S12
pubmed: 31647155
Anticancer Res. 2015 Oct;35(10):5383-9
pubmed: 26408700
Curr Opin Neurol. 2019 Oct;32(5):676-683
pubmed: 31306214
Mol Pharmacol. 1990 Nov;38(5):624-33
pubmed: 1978242
J Peripher Nerv Syst. 2019 Oct;24 Suppl 2:S40-S51
pubmed: 31647157
Mol Pain. 2010 Nov 30;6:84
pubmed: 21118538
J Clin Oncol. 2020 Oct 1;38(28):3325-3348
pubmed: 32663120
J Mol Neurosci. 2019 Aug;68(4):603-619
pubmed: 31077084
Cell Signal. 1989;1(3):259-68
pubmed: 2701803
Trends Mol Med. 2016 May;22(5):377-390
pubmed: 27085813
Methods Mol Biol. 2014;1175:301-22
pubmed: 25150874
Eur J Pharmacol. 2004 Apr 12;489(3):193-6
pubmed: 15087242
Neurobiol Dis. 2021 Nov;159:105480
pubmed: 34411705
Anticancer Res. 2011 Dec;31(12):4413-6
pubmed: 22199308
Cell Calcium. 2020 May;87:102190
pubmed: 32199208
J Pharmacol Exp Ther. 2004 Jul;310(1):83-9
pubmed: 15028781
Neuropharmacology. 2020 Mar 1;164:107905
pubmed: 31811874
Ann N Y Acad Sci. 2007 Mar;1099:413-26
pubmed: 17446481
Science. 1988 Oct 7;242(4875):81-4
pubmed: 2845577
J Peripher Nerv Syst. 2014 Dec;19(4):299-306
pubmed: 25582667
Clin Cancer Res. 2006 Aug 1;12(15):4481-4
pubmed: 16899592
J Peripher Nerv Syst. 2019 Oct;24 Suppl 2:S26-S39
pubmed: 31647151
Front Biosci. 2008 May 01;13:3506-24
pubmed: 18508452
Neurochem Int. 2011 Aug;59(1):51-8
pubmed: 21672583
J Cereb Blood Flow Metab. 2006 Apr;26(4):502-17
pubmed: 16107787
Nature. 1990 May 31;345(6274):410-6
pubmed: 2342572
J Neurophysiol. 2020 Jul 1;124(1):232-244
pubmed: 32519566
Physiol Rev. 1999 Jul;79(3):763-854
pubmed: 10390518
J Peripher Nerv Syst. 2019 Oct;24 Suppl 2:S52-S62
pubmed: 31647153
Front Pharmacol. 2012 Feb 23;3:19
pubmed: 22375118
J Neurosci. 2013 Dec 4;33(49):19250-61
pubmed: 24305821
Neuro Oncol. 2012 Sep;14 Suppl 4:iv45-54
pubmed: 23095830
Expert Opin Drug Metab Toxicol. 2017 Mar;13(3):241-243
pubmed: 27819147
Brain. 2009 Oct;132(Pt 10):2712-23
pubmed: 19745023
J Pharmacol Exp Ther. 2012 Nov;343(2):325-32
pubmed: 22879384
Transl Stroke Res. 2015 Jun;6(3):181-90
pubmed: 25860439
Pharmacol Rev. 2004 Dec;56(4):633-54
pubmed: 15602012
Eur J Pharmacol. 2000 Oct 6;406(1):25-32
pubmed: 11011028
J Neurosci. 1992 Feb;12(2):430-9
pubmed: 1311030
Exp Neurol. 2020 Mar;325:113141
pubmed: 31865195
Exp Neurol. 2021 Mar;337:113555
pubmed: 33340795
Eur J Cancer. 2001 Dec;37(18):2457-63
pubmed: 11720843

Auteurs

Elisa Ballarini (E)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Alessio Malacrida (A)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Virginia Rodriguez-Menendez (V)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Eleonora Pozzi (E)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Annalisa Canta (A)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Alessia Chiorazzi (A)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Laura Monza (L)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Sara Semperboni (S)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Cristina Meregalli (C)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Valentina Alda Carozzi (VA)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Maryamsadat Hashemi (M)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Gabriella Nicolini (G)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Arianna Scuteri (A)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Stephen N Housley (SN)

Integrated Cancer Research Center, School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA.

Guido Cavaletti (G)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Paola Alberti (P)

School of Medicine and Surgery, University of Milano-Bicocca, 20126 Milan, Italy.
NeuroMI (Milan Center for Neuroscience), 20126 Milan, Italy.

Articles similaires

Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH