Effect of Calcium-Sulphate-Bicarbonate Water in a Murine Model of Non-Alcoholic Fatty Liver Disease: A Histopathology Study.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
02 Sep 2022
Historique:
received: 29 07 2022
revised: 29 08 2022
accepted: 31 08 2022
entrez: 9 9 2022
pubmed: 10 9 2022
medline: 14 9 2022
Statut: epublish

Résumé

The progression of nonalcoholic fatty liver disease (NAFLD) is associated with alterations of the gut-liver axis. The activation of toll-like receptor 4 (TLR4) pathways by endotoxins, such as lipopolysaccharide (LPS), contributes to liver injury. The aim of the present study was to evaluate the possible beneficial effects of a calcium-sulphate-bicarbonate natural mineral water on the gut-liver axis by evaluating liver and terminal ileum histopathology in a murine model of NAFLD. NAFLD was induced in mice by administrating a methionine-choline-deficient (MCD) diet. The following experimental groups were evaluated: controls (N = 10); MCD+Tap water (MCD; N = 10); MCD+Calcium-sulphate-bicarbonate water (MCD/W

Identifiants

pubmed: 36077461
pii: ijms231710065
doi: 10.3390/ijms231710065
pmc: PMC9456359
pii:
doi:

Substances chimiques

Bicarbonates 0
Lipopolysaccharides 0
Mineral Waters 0
Sulfates 0
Toll-Like Receptor 4 0
Methionine AE28F7PNPL
Choline N91BDP6H0X
Calcium SY7Q814VUP
Calcium Sulfate WAT0DDB505

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : FoRST - Fondazione per la Ricerca Scientifica Termale
ID : Code: 1136

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Auteurs

Guido Carpino (G)

Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy.

Diletta Overi (D)

Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy.

Paolo Onori (P)

Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy.

Antonio Franchitto (A)

Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy.

Vincenzo Cardinale (V)

Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, Italy.

Domenico Alvaro (D)

Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.

Eugenio Gaudio (E)

Department of Anatomical, Histological, Forensic Medicine and Orthopedic Sciences, Sapienza University of Rome, 00161 Rome, Italy.

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Classifications MeSH