Transcriptional Regulation of Endogenous Retroviruses and Their Misregulation in Human Diseases.
cancer
endogenous retroviruses (ERVs)
neurodegenerative diseases
transcriptional regulation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Sep 2022
04 Sep 2022
Historique:
received:
11
07
2022
revised:
28
08
2022
accepted:
01
09
2022
entrez:
9
9
2022
pubmed:
10
9
2022
medline:
14
9
2022
Statut:
epublish
Résumé
Endogenous retroviruses (ERVs), deriving from exogenous retroviral infections of germ line cells occurred millions of years ago, represent ~8% of human genome. Most ERVs are highly inactivated because of the accumulation of mutations, insertions, deletions, and/or truncations. However, it is becoming increasingly apparent that ERVs influence host biology through genetic and epigenetic mechanisms under particular physiological and pathological conditions, which provide both beneficial and deleterious effects for the host. For instance, certain ERVs expression is essential for human embryonic development. Whereas abnormal activation of ERVs was found to be involved in numbers of human diseases, such as cancer and neurodegenerative diseases. Therefore, understanding the mechanisms of regulation of ERVs would provide insights into the role of ERVs in health and diseases. Here, we provide an overview of mechanisms of transcriptional regulation of ERVs and their dysregulation in human diseases.
Identifiants
pubmed: 36077510
pii: ijms231710112
doi: 10.3390/ijms231710112
pmc: PMC9456331
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China
ID : 31730020
Organisme : National Natural Science Foundation of China
ID : 32000512
Organisme : National Natural Science Foundation of China
ID : 31801155
Organisme : Hangzhou Science and Technology Bureau
ID : 20182014B01
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