How Microbiota-Derived Metabolites Link the Gut to the Brain during Neuroinflammation.
experimental autoimmune encephalomyelitis
gut–brain axis
microbiota-derived metabolites
multiple sclerosis
neuroinflammation
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
04 Sep 2022
04 Sep 2022
Historique:
received:
30
07
2022
revised:
29
08
2022
accepted:
01
09
2022
entrez:
9
9
2022
pubmed:
10
9
2022
medline:
14
9
2022
Statut:
epublish
Résumé
Microbiota-derived metabolites are important molecules connecting the gut to the brain. Over the last decade, several studies have highlighted the importance of gut-derived metabolites in the development of multiple sclerosis (MS). Indeed, microbiota-derived metabolites modulate the immune system and affect demyelination. Here, we discuss the current knowledge about microbiota-derived metabolites implications in MS and in different mouse models of neuroinflammation. We focus on the main families of microbial metabolites that play a role during neuroinflammation. A better understanding of the role of those metabolites may lead to new therapeutical avenues to treat neuroinflammatory diseases targeting the gut-brain axis.
Identifiants
pubmed: 36077526
pii: ijms231710128
doi: 10.3390/ijms231710128
pmc: PMC9456539
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Swiss National Science Foundation
ID : 310030_192738
Pays : Switzerland
Organisme : Biaggi Foundation
ID : 0
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