Genomic and Epigenomic Characterization of Tumor Organoid Models.
biomarker
epigenomics
genomics
organoid
patient-derived organoid
pharmacogenomics
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
24 Aug 2022
24 Aug 2022
Historique:
received:
03
08
2022
revised:
20
08
2022
accepted:
22
08
2022
entrez:
9
9
2022
pubmed:
10
9
2022
medline:
10
9
2022
Statut:
epublish
Résumé
Tumor organoid modeling has been recognized as a state-of-the-art system for in vitro research on cancer biology and precision oncology. Organoid culture technologies offer distinctive advantages, including faithful maintenance of physiological and pathological characteristics of human disease, self-organization into three-dimensional multicellular structures, and preservation of genomic and epigenomic landscapes of the originating tumor. These features effectively position organoid modeling between traditional cell line cultures in two dimensions and in vivo animal models as a valid, versatile, and robust system for cancer research. Here, we review recent advances in genomic and epigenomic characterization of tumor organoids and the novel findings obtained, highlight significant progressions achieved in organoid modeling of gene-drug interactions and genotype-phenotype associations, and offer perspectives on future opportunities for organoid modeling in basic and clinical cancer research.
Identifiants
pubmed: 36077628
pii: cancers14174090
doi: 10.3390/cancers14174090
pmc: PMC9454968
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : R37 CA237022
Pays : United States
Organisme : NCI NIH HHS
ID : P30CA014089
Pays : United States
Organisme : NIH HHS
ID : R37CA237022
Pays : United States
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