Molecular Alterations and Severe Abnormalities in Spermatozoa of Young Men Living in the "Valley of Sacco River" (Latium, Italy): A Preliminary Study.
human protamines
human spermatozoa
male fertility
protein–DNA binding
reproduction
sperm nuclear basic proteins
spermatozoa morphology
volatile organic compounds
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
03 09 2022
03 09 2022
Historique:
received:
13
07
2022
revised:
24
08
2022
accepted:
31
08
2022
entrez:
9
9
2022
pubmed:
10
9
2022
medline:
14
9
2022
Statut:
epublish
Résumé
The Valley of Sacco River (VSR) (Latium, Italy) is an area with large-scale industrial chemical production that has led over time to significant contamination of soil and groundwater with various industrial pollutants, such as organic pesticides, dioxins, organic solvents, heavy metals, and particularly, volatile organic compounds (VOCs). In the present study, we investigated the potential impact of VOCs on the spermatozoa of healthy young males living in the VSR, given the prevalent presence of several VOCs in the semen of these individuals. To accomplish this, spermiograms were conducted followed by molecular analyses to assess the content of sperm nuclear basic proteins (SNBPs) in addition to the protamine-histone ratio and DNA binding of these proteins. We found drastic alterations in the spermatozoa of these young males living in the VSR. Alterations were seen in sperm morphology, sperm motility, sperm count, and protamine/histone ratios, and included significant reductions in SNBP-DNA binding capacity. Our results provide preliminary indications of a possible correlation between the observed alterations and the presence of specific VOCs.
Identifiants
pubmed: 36078739
pii: ijerph191711023
doi: 10.3390/ijerph191711023
pmc: PMC9518305
pii:
doi:
Substances chimiques
Histones
0
Nuclear Proteins
0
Protamines
0
Volatile Organic Compounds
0
sperm basic nuclear proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Environ Sci Pollut Res Int. 2021 Jul;28(28):37031-37040
pubmed: 34053043
DNA Cell Biol. 2010 Jul;29(7):339-47
pubmed: 20438368
Annu Rev Pharmacol Toxicol. 1997;37:91-117
pubmed: 9131248
Hum Reprod Update. 2006 Jul-Aug;12(4):417-35
pubmed: 16581810
Eur J Med Chem. 2006 Dec;41(12):1439-45
pubmed: 17000033
J Breath Res. 2014 Mar;8(1):014001
pubmed: 24421258
Sci Rep. 2018 May 9;8(1):7414
pubmed: 29743544
DNA Cell Biol. 2015 Mar;34(3):162-9
pubmed: 25494411
Andrologia. 2020 Nov;52(10):e13784
pubmed: 32721052
Occup Environ Med. 2009 Nov;66(11):725-32
pubmed: 19416805
Environ Toxicol Pharmacol. 2018 Mar;58:243-249
pubmed: 29448163
J Chromatogr Sci. 2015 Sep;53(8):1257-64
pubmed: 25637135
Int J Environ Res Public Health. 2021 Jun 25;18(13):
pubmed: 34202243
Mol Cell Proteomics. 2002 Nov;1(11):885-95
pubmed: 12488464
Hum Reprod Update. 2010 May-Jun;16(3):231-45
pubmed: 19934213
Environ Health Perspect. 2010 Jun;118(6):833-9
pubmed: 20418200
Sci Total Environ. 2017 Dec 1;601-602:230-236
pubmed: 28554114
Fertil Steril. 2018 Oct;110(5):810-814
pubmed: 30316415
Arch Toxicol. 2019 Jan;93(1):137-147
pubmed: 30327826
Toxicol Lett. 1990 Nov;54(1):61-9
pubmed: 2123045
Arch Toxicol. 1989;63(4):296-307
pubmed: 2764718
Chem Sci. 2018 Jan 31;9(10):2655-2665
pubmed: 29719674
Drug Metab Rev. 2005;37(1):41-213
pubmed: 15747500
Reprod Sci. 2022 Jan;29(1):7-25
pubmed: 33289064
Environ Sci Pollut Res Int. 2017 Dec;24(34):26185-26193
pubmed: 28567683
Asian J Androl. 2015 Nov-Dec;17(6):954-60
pubmed: 25851659
Int J Fertil. 1980;25(4):281-6
pubmed: 6114050
Int J Environ Res Public Health. 2021 Aug 21;18(16):
pubmed: 34444582
Environ Pollut. 2022 Jul 1;304:119119
pubmed: 35341815
Mutat Res. 1981 Mar;81(1):11-9
pubmed: 7019684
Environ Pollut. 2021 Oct 1;286:117410
pubmed: 34052646
Reprod Fertil Dev. 2016;28(1-2):1-10
pubmed: 27062870
Environ Sci Pollut Res Int. 2016 Dec;23(23):23339-23348
pubmed: 27672044
Reprod Toxicol. 2016 Dec;66:1-9
pubmed: 27592743
Int J Mol Sci. 2020 Sep 04;21(18):
pubmed: 32899890
J Food Drug Anal. 2018 Jul;26(3):965-972
pubmed: 29976414
Epidemiol Prev. 2012 Sep-Oct;36(5 Suppl 4):44-52
pubmed: 23139188
Acta Biochim Pol. 2012;59(2):275-8
pubmed: 22693686
Cell Rep. 2018 Jun 26;23(13):3920-3932
pubmed: 29949774
Antioxidants (Basel). 2020 Feb 04;9(2):
pubmed: 32033035
Nature. 2009 Jul 23;460(7254):473-8
pubmed: 19525931
Biochim Biophys Acta. 2014 Mar;1839(3):155-68
pubmed: 24091090
Semin Reprod Med. 2017 May;35(3):203-204
pubmed: 28658702
Environ Health Perspect. 2012 Feb;120(2):229-34
pubmed: 22086566
Int J Mol Sci. 2017 Aug 04;18(8):
pubmed: 28777293
Acta Biochim Pol. 2018;65(2):259-267
pubmed: 29906296
Arh Hig Rada Toksikol. 2021 Jun 28;72(3):101-113
pubmed: 34187108
Int J Mol Sci. 2020 Sep 13;21(18):
pubmed: 32933216
DNA Cell Biol. 2012 Aug;31(8):1392-402
pubmed: 22536787
Cell Rep. 2017 Feb 7;18(6):1366-1382
pubmed: 28178516
Mol Reprod Dev. 2019 Oct;86(10):1357-1368
pubmed: 30648312
J Pharmacol Exp Ther. 1983 May;225(2):479-86
pubmed: 6682442
Semin Reprod Med. 2017 May;35(3):282-290
pubmed: 28658712
Environ Health. 2020 Jan 22;19(1):9
pubmed: 31969154
Int J Mol Sci. 2021 Feb 05;22(4):
pubmed: 33562685
Eur Urol Focus. 2022 Jan;8(1):351-359
pubmed: 33579652
Mol Reprod Dev. 2019 Jun;86(6):650-660
pubmed: 30938011
Int J Mol Sci. 2021 May 31;22(11):
pubmed: 34072703
Nat Prod Res. 2015;29(12):1166-9
pubmed: 25922109
Mol Reprod Dev. 2019 Oct;86(10):1418-1429
pubmed: 31317589
Nat Struct Mol Biol. 2010 Jun;17(6):679-87
pubmed: 20473313
Ecotoxicol Environ Saf. 2019 Mar;169:600-606
pubmed: 30496991
J Androl. 1988 Nov-Dec;9(6):357-66
pubmed: 3215822
Reproduction. 2016 May;151(5):R55-70
pubmed: 26850883
J Appl Toxicol. 2014 Aug;34(8):825-34
pubmed: 24852913
Int J Mol Sci. 2020 Jun 12;21(12):
pubmed: 32545547
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Toxics. 2022 Jul 01;10(7):
pubmed: 35878270
Environ Sci Pollut Res Int. 2018 May;25(13):12957-12966
pubmed: 29478169
Protein Pept Lett. 2018;25(5):424-433
pubmed: 29651936
Int J Mol Sci. 2022 Jan 29;23(3):
pubmed: 35163492
J Food Drug Anal. 2016 Oct;24(4):682-694
pubmed: 28911605
Antioxidants (Basel). 2019 Jul 11;8(7):
pubmed: 31336755
J Reprod Med. 2015 Jan-Feb;60(1-2):6-12
pubmed: 25745745
Epidemiol Prev. 2012 Sep-Oct;36(5 Suppl 4):34-43
pubmed: 23139187