Intestinal Permeability and Depression in Patients with Inflammatory Bowel Disease.
IFAB
LBP
biomarkers
calprotectin
leaky gut syndrome
psychiatric disorders
zonulin
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
30 Aug 2022
30 Aug 2022
Historique:
received:
07
07
2022
revised:
16
08
2022
accepted:
26
08
2022
entrez:
9
9
2022
pubmed:
10
9
2022
medline:
10
9
2022
Statut:
epublish
Résumé
Depression is a global health problem that requires an early and accurate diagnosis to ensure quick access to appropriate treatment. Among multiple psychopathological paths, recent attention has focused on analysing the brain-gut-microbiota axis. The intestinal barrier plays a key role, and dysfunctions occurring at this level have implications for mental health. The aim of the present study was to investigate the role of intestinal permeability biomarkers, i.e., calprotectin, zonulin, lipopolysaccharide-binding protein (LBP) and intestinal fatty acid-binding protein (I-FAB), in relation to depression in patients with inflammatory bowel disease (IBD). This is the first study of this kind taking place in Romania, Eastern Europe, with an emphasis on patients with Crohn's disease and ulcerative colitis. The correlations identified between depression and calprotectin and depression and LBP have the potential to shed light on the process of rapid diagnosis of depression with the help of biomarkers. Since depression is correlated with a decrease in the quality of life in patients with IBD, the need for access to appropriate treatments must be urgent.
Identifiants
pubmed: 36079050
pii: jcm11175121
doi: 10.3390/jcm11175121
pmc: PMC9457405
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ovidius University
ID : This work was funded by Ovidius University of Constanta, Romania, through the ROBICADE grant number 4/13.10.2020. The grant was won in the "Competition for research grants in biomedical field 2020" sustained in Ovidius University of Constanta.
Organisme : ANTREPRENORDOC
ID : This work is supported by the project ANTREPRENORDOC, in the framework of Human Resources Development Operational Programme 2014-2020, financed from the European Social Fund under the contract number 36355/23.05.2019 HRD OP /380/6/13 - SMIS Code: 123847
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