Gallium (III) Complexes with 5-Bromosalicylaldehyde Benzoylhydrazones: In Silico Studies and In Vitro Cytotoxic Activity.
5-bromosalicylaldehyde
DFT calculations
cytotoxic activity
gallium (III) complexes
hydrazones
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
26 Aug 2022
26 Aug 2022
Historique:
received:
27
07
2022
revised:
17
08
2022
accepted:
24
08
2022
entrez:
9
9
2022
pubmed:
10
9
2022
medline:
14
9
2022
Statut:
epublish
Résumé
Gallium (III) complexes with the ligands 5-bromosalicylaldehyde-4-hydroxybenzoylhydrazone and 5-bromosalicylaldehyde isonicotinoylhydrazone were synthesized to receive compounds with improved antiproliferative action. Compounds were characterized by elemental analysis, IR, and NMR spectroscopy. Density functional theory calculations with Becke's 3-parameter hybrid functional and 6-31+G(d,p) basis set were carried out to investigate the structural features of the ligands and Ga(III) complexes. Cytotoxic screening by MTT-dye reduction assay was carried out using cisplatin and melphalan as reference cytotoxic agents. A general formula [Ga(HL)
Identifiants
pubmed: 36080261
pii: molecules27175493
doi: 10.3390/molecules27175493
pmc: PMC9457627
pii:
doi:
Substances chimiques
Aldehydes
0
Antineoplastic Agents
0
Coordination Complexes
0
Ligands
0
5-bromosalicylaldehyde
0Z65A0A8CE
Gallium
CH46OC8YV4
Cisplatin
Q20Q21Q62J
Melphalan
Q41OR9510P
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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