Role of adropin in arterial stiffening associated with obesity and type 2 diabetes.
adropin
endothelial cells
mesenteric arteries
nitric oxide
smooth muscle cellss
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 11 2022
01 11 2022
Historique:
pubmed:
10
9
2022
medline:
20
10
2022
entrez:
9
9
2022
Statut:
ppublish
Résumé
Adropin is a peptide largely secreted by the liver and known to regulate energy homeostasis; however, it also exerts cardiovascular effects. Herein, we tested the hypothesis that low circulating levels of adropin in obesity and type 2 diabetes (T2D) contribute to arterial stiffening. In support of this hypothesis, we report that obesity and T2D are associated with reduced levels of adropin (in liver and plasma) and increased arterial stiffness in mice and humans. Establishing causation, we show that mesenteric arteries from adropin knockout mice are also stiffer, relative to arteries from wild-type counterparts, thus recapitulating the stiffening phenotype observed in T2D
Identifiants
pubmed: 36083795
doi: 10.1152/ajpheart.00385.2022
pmc: PMC9602697
doi:
Substances chimiques
Actins
0
Peptides
0
Nitric Oxide
31C4KY9ESH
Nitric Oxide Synthase
EC 1.14.13.39
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
H879-H891Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL088105
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137769
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK116081
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK113701
Pays : United States
Références
J Clin Endocrinol Metab. 2012 Oct;97(10):3783-91
pubmed: 22872690
Regul Pept. 2014 May;190-191:46-9
pubmed: 24731968
Life Sci. 2016 Sep 1;160:41-46
pubmed: 27449397
Am J Physiol Cell Physiol. 2008 Sep;295(3):C768-78
pubmed: 18596213
J Am Coll Cardiol. 2010 Mar 30;55(13):1318-27
pubmed: 20338492
Med Princ Pract. 2019;28(5):463-469
pubmed: 30995640
Free Radic Biol Med. 2020 Nov 20;160:191-198
pubmed: 32810635
JAMA Netw Open. 2019 Oct 2;2(10):e1912831
pubmed: 31596491
Am J Physiol Regul Integr Comp Physiol. 2018 Mar 1;314(3):R387-R398
pubmed: 29167167
Mediators Inflamm. 2016;2016:6038261
pubmed: 27546995
Cell Death Dis. 2017 Aug 24;8(8):e3008
pubmed: 28837146
Am J Physiol Heart Circ Physiol. 2020 Dec 1;319(6):H1338-H1346
pubmed: 33035441
Metabolism. 2019 Sep;98:37-48
pubmed: 31202835
Curr Opin Cardiol. 2002 Sep;17(5):543-51
pubmed: 12357133
Int J Mol Sci. 2018 Apr 26;19(5):
pubmed: 29701665
Cardiovasc Res. 2013 Jun 1;98(3):428-36
pubmed: 23417038
NCHS Data Brief. 2020 Feb;(360):1-8
pubmed: 32487284
Circulation. 2003 Nov 4;108(18):2230-5
pubmed: 14557363
J Am Coll Cardiol. 2003 Dec 3;42(11):1975-81
pubmed: 14662262
J Biol Chem. 2019 Sep 6;294(36):13366-13377
pubmed: 31324719
Curr Res Physiol. 2022 Jan 25;5:55-62
pubmed: 35128468
Microcirculation. 2010 Jan;17(1):47-58
pubmed: 20141600
Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2282-7
pubmed: 21262838
J Am Heart Assoc. 2021 May 18;10(10):e020641
pubmed: 33938228
Adv Clin Exp Med. 2019 Nov;28(11):1571-1575
pubmed: 31756066
J Hum Hypertens. 2014 Aug;28(8):475-81
pubmed: 24430704
J Physiol. 2019 Apr;597(7):1791-1804
pubmed: 30690728
Clin Chem Lab Med. 2014 May;52(5):751-8
pubmed: 24323892
Circulation. 2006 Feb 7;113(5):657-63
pubmed: 16461838
Br J Anaesth. 1990 Jun;64(6):696-703
pubmed: 2165795
Physiology (Bethesda). 2009 Feb;24:45-57
pubmed: 19196651
J Am Heart Assoc. 2017 Feb 3;6(2):
pubmed: 28159817
Hypertension. 2020 Aug;76(2):393-403
pubmed: 32594801
Anatol J Cardiol. 2017 Feb;17(2):119-124
pubmed: 27684517
Front Physiol. 2015 Aug 14;6:231
pubmed: 26321962
PLoS One. 2011;6(8):e23337
pubmed: 21829729
Am J Physiol Heart Circ Physiol. 2022 Feb 1;322(2):H167-H180
pubmed: 34890280
Am J Physiol Heart Circ Physiol. 2003 Jul;285(1):H104-11
pubmed: 12649071
Metabolism. 2021 Jun;119:154766
pubmed: 33766485
Clin Sci (Lond). 1980 Dec;59 Suppl 6:279s-282s
pubmed: 7449271
Biomedicines. 2021 Oct 07;9(10):
pubmed: 34680524
Free Radic Biol Med. 2006 Aug 15;41(4):541-8
pubmed: 16863986
Am J Physiol Regul Integr Comp Physiol. 2022 Jul 1;323(1):R43-R58
pubmed: 35470695
Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H644-H657
pubmed: 29775408
PLoS One. 2014 Oct 03;9(10):e109017
pubmed: 25280018
Am J Physiol Heart Circ Physiol. 2016 Jan 15;310(2):H188-98
pubmed: 26566730
Amino Acids. 2013 Jan;44(1):261-9
pubmed: 21984378
Hypertension. 2015 Sep;66(3):698-722
pubmed: 26160955
Circ Res. 2010 Sep 3;107(5):615-9
pubmed: 20634486
JRSM Cardiovasc Dis. 2012 Jul 31;1(4):
pubmed: 24175067
Circulation. 2005 Dec 13;112(24):3722-8
pubmed: 16330686
Front Physiol. 2021 Mar 29;12:588358
pubmed: 33854438
J Mol Cell Cardiol. 2019 Apr;129:174-178
pubmed: 30822408
Exp Cell Res. 2017 Nov 15;360(2):236-242
pubmed: 28899659
Circulation. 2010 Sep 14;122(11 Suppl):S185-92
pubmed: 20837912
Hepatology. 2022 Nov;76(5):1452-1465
pubmed: 35000203
J Clin Lab Anal. 2019 Feb;33(2):e22672
pubmed: 30239031
Endocr J. 2018 Jul 28;65(7):685-691
pubmed: 29669965
Cardiorenal Med. 2014 Apr;4(1):60-71
pubmed: 24847335
J Anal Toxicol. 1982 May-Jun;6(3):148-52
pubmed: 7109559
Clin Chem Lab Med. 2017 Jan 1;55(1):139-144
pubmed: 27474839
Cardiovasc Res. 2018 Mar 15;114(4):529-539
pubmed: 29394331
Cell Metab. 2008 Dec;8(6):468-81
pubmed: 19041763
Nitric Oxide. 2020 Aug 1;100-101:17-29
pubmed: 32339668
Obesity (Silver Spring). 2012 Jul;20(7):1394-402
pubmed: 22318315
J Am Coll Cardiol. 2014 Feb 25;63(7):636-646
pubmed: 24239664
Postepy Hig Med Dosw (Online). 2016 Sep 26;70(0):981-988
pubmed: 27668650
J Investig Med. 2013 Dec;61(8):1161-4
pubmed: 24113736
Front Physiol. 2015 Nov 18;6:335
pubmed: 26635621
Am J Mens Health. 2017 Mar;11(2):426-434
pubmed: 27550773
Geroscience. 2022 Jun;44(3):1657-1675
pubmed: 35426600
Antioxid Redox Signal. 2019 Mar 1;30(7):945-959
pubmed: 29433330
Circulation. 2010 Feb 2;121(4):505-11
pubmed: 20083680
Cell Physiol Biochem. 2017;44(2):701-715
pubmed: 29169155
Circ Cardiovasc Imaging. 2016 Dec;9(12):
pubmed: 27956408
Redox Biol. 2018 Sep;18:25-32
pubmed: 29909017