High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened.
D. melanogaster
Drosophila
apico-basal polarity
developmental biology
hedgehog
phosphorylation
protein trafficking
smoothened
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
09 09 2022
09 09 2022
Historique:
received:
29
04
2022
accepted:
22
08
2022
entrez:
9
9
2022
pubmed:
10
9
2022
medline:
14
9
2022
Statut:
epublish
Résumé
The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures. Here, we examine how HH controls SMO subcellular localization and activity in a polarized epithelium using the
Identifiants
pubmed: 36083801
doi: 10.7554/eLife.79843
pii: 79843
pmc: PMC9462849
doi:
pii:
Substances chimiques
Drosophila Proteins
0
Hedgehog Proteins
0
Receptors, G-Protein-Coupled
0
Smoothened Receptor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022, Gonçalves Antunes et al.
Déclaration de conflit d'intérêts
MG, MS, VC, SC, AP, IB No competing interests declared
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