Oral Fluorescein Angiography for the Diagnosis of Papilledema Versus Pseudopapilledema in Children.

Humans Child Female Adolescent Male Papilledema / diagnosis Fluorescein Angiography / methods Retrospective Studies Retinal Ganglion Cells Tomography, Optical Coherence / methods

Journal

American journal of ophthalmology
ISSN: 1879-1891
Titre abrégé: Am J Ophthalmol
Pays: United States
ID NLM: 0370500

Informations de publication

Date de publication:
01 2023
Historique:
received: 29 06 2022
revised: 21 08 2022
accepted: 22 08 2022
pubmed: 10 9 2022
medline: 17 12 2022
entrez: 9 9 2022
Statut: ppublish

Résumé

To evaluate the accuracy and safety of oral fluorescein angiography (OFA) in differentiating papilledema from pseudopapilledema in pediatric patients. Retrospective evaluation of a diagnostic test. We retrospectively reviewed medical records of all children ≤18 years of age who presented to the Arkansas Children's Hospital between May 2018 and August 2021 with suspected optic disc (OD) swelling that had OFA and images >30 minutes after oral ingestion. Two masked specialists interpreted the images as either OD leakage, no leakage, or borderline leakage. Optic disc swelling was graded clinically according to the Frisen grading scale (0-5). We compared OFA images to the final clinical diagnosis and calculated the accuracy of the test as follows: (number of eyes correctly identified as papilledema [true positive] + number of eyes correctly identified as pseudopapilledema [true negative]) / (total number of eyes) × 100%. Forty-five patients (90 eyes) were included, 11 patients with papilledema and 34 with pseudopapilledema. The mean age was 14.1 ± 3.5 years; 66.7% were female. The accuracy of OFA was 62% for reviewer 1 and 69% for reviewer 2. No ocular or systemic side effects after OFA were observed. There was substantial agreement (k = 0.779) between both reviewers in grading the OFA images. OFA cannot definitively distinguish papilledema from pseudopapilledema in children and should be interpreted in conjunction with other clinical findings.

Identifiants

DOI: 10.1016/j.ajo.2022.08.020 PMID: 36084685
pubmed: 36084685
pii: S0002-9394(22)00340-3
doi: 10.1016/j.ajo.2022.08.020
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8-13

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Abdelrahman M Elhusseiny (AM)

From the Department of Ophthalmology (A.M.E., J.W.F., C.H., F.G., A.P.G., A.B.S., S.H.U., P.H.P.), Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Joseph W Fong (JW)

From the Department of Ophthalmology (A.M.E., J.W.F., C.H., F.G., A.P.G., A.B.S., S.H.U., P.H.P.), Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas; and the Department of Ophthalmology (J.W.F., M.K.S.), Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Christine Hsu (C)

From the Department of Ophthalmology (A.M.E., J.W.F., C.H., F.G., A.P.G., A.B.S., S.H.U., P.H.P.), Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Florin Grigorian (F)

From the Department of Ophthalmology (A.M.E., J.W.F., C.H., F.G., A.P.G., A.B.S., S.H.U., P.H.P.), Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

A Paula Grigorian (AP)

From the Department of Ophthalmology (A.M.E., J.W.F., C.H., F.G., A.P.G., A.B.S., S.H.U., P.H.P.), Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Mohamed K Soliman (MK)

and the Department of Ophthalmology (J.W.F., M.K.S.), Hamilton Eye Institute, University of Tennessee Health Science Center, Memphis, Tennessee, USA.

Ahmed B Sallam (AB)

From the Department of Ophthalmology (A.M.E., J.W.F., C.H., F.G., A.P.G., A.B.S., S.H.U., P.H.P.), Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Sami H Uwaydat (SH)

From the Department of Ophthalmology (A.M.E., J.W.F., C.H., F.G., A.P.G., A.B.S., S.H.U., P.H.P.), Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas.

Paul H Phillips (PH)

From the Department of Ophthalmology (A.M.E., J.W.F., C.H., F.G., A.P.G., A.B.S., S.H.U., P.H.P.), Harvey and Bernice Jones Eye Institute, University of Arkansas for Medical Sciences, Little Rock, Arkansas. Electronic address: PhillipsPaulH@uams.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Oral Fluorescein Angiography for the Diagnosis...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Oral Fluorescein Angiography for the Diagnosis...
questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Oral Fluorescein Angiography for the Diagnosis...
questionsmedicales.fr › Maladies de l'oeil › Atteintes du nerf optique › Oedème papillaire › Oral Fluorescein Angiography for the Diagnosis...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic ophtalmologique › Angiographie fluorescéinique › Oral Fluorescein Angiography for the Diagnosis...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Oral Fluorescein Angiography for the Diagnosis...
questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Neurones rétiniens › Cellules ganglionnaires rétiniennes › Oral Fluorescein Angiography for the Diagnosis...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › Tomographie optique › Tomographie par cohérence optique › Oral Fluorescein Angiography for the Diagnosis...