Reprint of: Advanced paternal age and risk of schizophrenia in offspring - Review of epidemiological findings and potential mechanisms.
Advanced paternal age
Delayed fatherhood
Paternal age
Psychiatric epidemiology
Schizophrenia
de novo mutations
Journal
Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
27
02
2021
revised:
17
06
2021
accepted:
21
06
2021
pubmed:
10
9
2022
medline:
21
9
2022
entrez:
9
9
2022
Statut:
ppublish
Résumé
A large number of studies have examined the association between advanced paternal age (APA) and risk of schizophrenia in offspring. Here we present an overview of epidemiological studies on this subject published since 2000, and systematically summarize their methodologies and results. Next, we discuss evidence to elucidate the potential mechanisms contributing to the association between APA and offspring schizophrenia, considering paternal psychiatric morbidity and genetic liability, maternal factors, and findings from family design studies. We propose that multiple mechanisms, including causal and non-causal pathways, contribute to the observed relationship between APA and schizophrenia in offspring, and conclude by highlighting the need for multi-disciplinary studies in disentangling these complex, non-mutually exclusive mechanisms.
Identifiants
pubmed: 36085274
pii: S0920-9964(22)00329-2
doi: 10.1016/j.schres.2022.08.023
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
84-91Subventions
Organisme : NIMH NIH HHS
ID : T32 MH122394
Pays : United States
Commentaires et corrections
Type : ReprintOf
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest None.