Logarithmically scaled, gamma distributed neuronal spiking.
cortical dark matter
excitation-inhibition balance
firing rate distribution
fluctuation-driven regime
interspike intervals
irregular spiking
log-normal
spike train analysis
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
08 2023
08 2023
Historique:
received:
09
05
2022
accepted:
28
07
2022
medline:
2
8
2023
pubmed:
11
9
2022
entrez:
10
9
2022
Statut:
ppublish
Résumé
Naturally log-scaled quantities abound in the nervous system. Distributions of these quantities have non-intuitive properties, which have implications for data analysis and the understanding of neural circuits. Here, we review the log-scaled statistics of neuronal spiking and the relevant analytical probability distributions. Recent work using log-scaling revealed that interspike intervals of forebrain neurons segregate into discrete modes reflecting spiking at different timescales and are each well-approximated by a gamma distribution. Each neuron spends most of the time in an irregular spiking 'ground state' with the longest intervals, which determines the mean firing rate of the neuron. Across the entire neuronal population, firing rates are log-scaled and well approximated by the gamma distribution, with a small number of highly active neurons and an overabundance of low rate neurons (the 'dark matter'). These results are intricately linked to a heterogeneous balanced operating regime, which confers upon neuronal circuits multiple computational advantages and has evolutionarily ancient origins.
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3055-3069Subventions
Organisme : Academy of Medical Sciences and Wellcome Trust
ID : SBF002∖1045
Organisme : BBSRC
ID : BB/P020607/1
Informations de copyright
© 2022 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
Références
Cell. 2016 Mar 24;165(1):180-191
pubmed: 26997481
J Neurosci. 2011 Nov 9;31(45):16217-26
pubmed: 22072673
Nat Neurosci. 2021 Jul;24(7):1010-1019
pubmed: 33986551
Neuron. 2016 Dec 7;92(5):1106-1121
pubmed: 27866797
Elife. 2019 Apr 25;8:
pubmed: 31021319
Neuron. 2008 Feb 28;57(4):482-97
pubmed: 18304479
J Neurosci. 2007 Dec 12;27(50):13802-12
pubmed: 18077692
PLoS Biol. 2008 Jan;6(1):e16
pubmed: 18232737
PLoS Comput Biol. 2015 Jul 09;11(7):e1004389
pubmed: 26158556
Science. 2016 Mar 25;351(6280):1440-3
pubmed: 27013730
Nature. 1999 Mar 25;398(6725):338-41
pubmed: 10192334
Nat Neurosci. 2021 Mar;24(3):326-330
pubmed: 33603228
Curr Opin Neurobiol. 1994 Aug;4(4):569-79
pubmed: 7812147
J Neurosci. 1993 Jan;13(1):334-50
pubmed: 8423479
J Neurosci. 1998 May 15;18(10):3870-96
pubmed: 9570816
Neuron. 2018 Sep 19;99(6):1289-1301.e2
pubmed: 30174117
J Neurosci. 1982 Jan;2(1):32-48
pubmed: 7054394
Nat Neurosci. 2014 Jun;17(6):858-65
pubmed: 24777419
J Neurosci. 2002 Jun 15;22(12):5118-28
pubmed: 12077207
PLoS Comput Biol. 2009 Jul;5(7):e1000433
pubmed: 19593378
Neuron. 2010 Dec 22;68(6):1043-50
pubmed: 21172607
Nature. 2003 Jul 31;424(6948):552-6
pubmed: 12891358
J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2006 Aug;192(8):777-84
pubmed: 16550391
Neuron. 2001 Oct 11;32(1):141-9
pubmed: 11604145
Nat Neurosci. 2010 Oct;13(10):1276-82
pubmed: 20802489
Cell. 2020 Oct 29;183(3):620-635.e22
pubmed: 33035454
J Neurophysiol. 2016 Aug 1;116(2):892-903
pubmed: 27306671
Prog Neurobiol. 1984;22(2):131-53
pubmed: 6433403
Front Syst Neurosci. 2021 Dec 10;15:752261
pubmed: 34955768
Sci Adv. 2018 Aug 01;4(8):eaar3230
pubmed: 30083600
PLoS Biol. 2005 Mar;3(3):e68
pubmed: 15737062
Cell Rep. 2013 Sep 12;4(5):1010-21
pubmed: 23994479
Nat Neurosci. 2016 Dec;19(12):1690-1696
pubmed: 27749827
Neuron. 2015 Aug 5;87(3):644-56
pubmed: 26212710
Cell Rep. 2022 Jan 18;38(3):110268
pubmed: 35045289
Science. 2004 Jun 25;304(5679):1926-9
pubmed: 15218136
Nat Neurosci. 2014 Apr;17(4):594-600
pubmed: 24561997
J Neurophysiol. 1996 May;75(5):1806-14
pubmed: 8734581
J Opt Soc Am A Opt Image Sci Vis. 1997 Mar;14(3):529-46
pubmed: 9058948
Elife. 2021 Jul 16;10:
pubmed: 34270411
Proc R Soc Lond B Biol Sci. 1976 Oct 15;194(1115):211-23
pubmed: 11486
Trends Cogn Sci. 2014 Sep;18(9):480-7
pubmed: 24788139
Phys Rev E. 2019 Aug;100(2-1):022208
pubmed: 31574753
Neuron. 2013 Dec 4;80(5):1263-76
pubmed: 24314731
Neural Comput. 2008 Jan;20(1):1-43
pubmed: 18044999
Elife. 2019 Jan 28;8:
pubmed: 30688649
Elife. 2016 Oct 26;5:
pubmed: 27782883
Nat Neurosci. 2010 Mar;13(3):369-78
pubmed: 20173745
Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Mar;89(3):030701
pubmed: 24730779
Science. 2007 Jan 19;315(5810):390-3
pubmed: 17234950
Prog Neurobiol. 2013 Apr;103:156-93
pubmed: 23123501
Nature. 2015 May 28;521(7553):511-515
pubmed: 25849776
J Neurosci. 2015 Oct 28;35(43):14585-601
pubmed: 26511248
Exp Neurol. 1973 Nov;41(2):461-531
pubmed: 4355646
Science. 1996 Dec 6;274(5293):1724-6
pubmed: 8939866
Nat Neurosci. 2016 Apr;19(4):634-641
pubmed: 26974951
Physiol Rev. 2020 Jan 1;100(1):271-320
pubmed: 31512990
Sci Rep. 2019 Jan 24;9(1):689
pubmed: 30679509
Nature. 2014 Jul 31;511(7511):596-600
pubmed: 25043046
Cereb Cortex. 2019 May 1;29(5):2196-2210
pubmed: 30796825
J Physiol Paris. 2000 Sep-Dec;94(5-6):445-63
pubmed: 11165912
Biol Cybern. 2006 Jul;95(1):1-19
pubmed: 16622699
J Comput Neurosci. 2010 Aug;29(1-2):351-365
pubmed: 19449094
Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 Dec;62(6 Pt B):8413-9
pubmed: 11138142
J Neurophysiol. 2005 Feb;93(2):1074-89
pubmed: 15356183
J Neurophysiol. 2003 Nov;90(5):3441-54
pubmed: 12773500
Neuron. 2018 May 16;98(4):846-860.e5
pubmed: 29772203
J Neurophysiol. 2011 Jul;106(1):361-73
pubmed: 21525364
Biophys J. 1965 Mar;5:173-94
pubmed: 14268952
Nature. 2008 Aug 21;454(7207):995-9
pubmed: 18650810
Nature. 2007 Nov 15;450(7168):425-9
pubmed: 18004384
J Neurosci. 2011 Jun 29;31(26):9481-8
pubmed: 21715613
Nat Neurosci. 2008 Nov;11(11):1335-42
pubmed: 18931665
Annu Rev Physiol. 2003;65:453-80
pubmed: 12471170
Brain Behav Evol. 1970;3(1):72-101
pubmed: 5522353
J Neurophysiol. 2002 Feb;87(2):653-9
pubmed: 11826034
J Neurosci. 2016 May 25;36(21):5736-47
pubmed: 27225764
Neuron. 2009 May 14;62(3):426-40
pubmed: 19447097
Annu Rev Neurosci. 2012;35:203-25
pubmed: 22443509
Neuron. 2019 Jul 17;103(2):292-308.e4
pubmed: 31171448
Trends Neurosci. 2012 Jun;35(6):345-55
pubmed: 22579264
Neural Comput. 1999 Oct 1;11(7):1621-71
pubmed: 10490941
Biophys J. 1964 Jan;4:41-68
pubmed: 14104072
Biol Cybern. 1999 May;80(5):291-7
pubmed: 10391694
Light Sci Appl. 2019 Nov 28;8:109
pubmed: 31798848
J Neurosci. 2015 Jun 3;35(22):8480-92
pubmed: 26041916
Neuron. 2021 Feb 17;109(4):663-676.e5
pubmed: 33333001
Nat Neurosci. 2012 Nov;15(11):1539-46
pubmed: 23086335
Nat Neurosci. 2009 Apr;12(4):483-91
pubmed: 19305402
Neuron. 2017 Apr 19;94(2):375-387.e7
pubmed: 28392071
Neuron. 2010 Sep 23;67(6):1048-61
pubmed: 20869600
Front Hum Neurosci. 2021 Sep 03;15:719388
pubmed: 34539363
Nat Rev Neurosci. 2014 Apr;15(4):264-78
pubmed: 24569488
Neuron. 2016 May 18;90(4):839-52
pubmed: 27133462
Neuron. 2018 Jul 11;99(1):227-238.e4
pubmed: 29909997
Nature. 2021 Apr;592(7852):86-92
pubmed: 33473216
Proc Natl Acad Sci U S A. 2019 Dec 26;116(52):27035-27042
pubmed: 31843934
J Physiol. 1952 Aug;117(4):500-44
pubmed: 12991237