Effects of trazodone administration on the neurologic examination in healthy dogs.
anxiety
canine
neurolocalization
neurology
sedation
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
10
03
2022
accepted:
24
08
2022
pubmed:
11
9
2022
medline:
2
12
2022
entrez:
10
9
2022
Statut:
ppublish
Résumé
Trazodone is an anxiolytic used PO to decrease anxiety in dogs. Whether or not trazodone affects the neurologic examination in dogs has not been previously reported. Investigate whether trazodone administration is associated with changes in the neurologic examination in healthy dogs. Thirty-two healthy dogs between 1 and 6 years old with no previously diagnosed medical conditions and perceived by their owners as neurologically normal. Baseline sedation and anxiety assessments and neurologic examination were performed on each dog, followed by trazodone administration (6.25-8.60 mg/kg PO). The sedation and anxiety assessments and neurologic examination were repeated 2.5 hours after trazodone administration. The examinations were performed by a single board-certified veterinary neurologist and were video-recorded. The videos were randomized and reviewed by a different neurologist, blinded to the previous evaluations, who scored the examinations. Seven of 32 (22%) dogs had worse scores on their neurologic examination after receiving trazodone, manifesting as new or progressive PR deficits. Although not clinically relevant, 18.7% of the dogs had consciousness levels that changed from bright, alert, responsive to quiet, alert, responsive after trazodone administration. No other changes were observed on neurologic examination. Sedation and anxiety scores were significantly different after trazodone administration compared to before (P < .001 and P < .001, respectively). Most dogs did not have changes on neurologic examination after trazodone administration. However, approximately 20% of dogs had new or worsening PR deficits after receiving trazodone. Ideally, trazodone should not be given before neurologic examination in dogs.
Sections du résumé
BACKGROUND
BACKGROUND
Trazodone is an anxiolytic used PO to decrease anxiety in dogs. Whether or not trazodone affects the neurologic examination in dogs has not been previously reported.
OBJECTIVE
OBJECTIVE
Investigate whether trazodone administration is associated with changes in the neurologic examination in healthy dogs.
ANIMALS
METHODS
Thirty-two healthy dogs between 1 and 6 years old with no previously diagnosed medical conditions and perceived by their owners as neurologically normal.
METHODS
METHODS
Baseline sedation and anxiety assessments and neurologic examination were performed on each dog, followed by trazodone administration (6.25-8.60 mg/kg PO). The sedation and anxiety assessments and neurologic examination were repeated 2.5 hours after trazodone administration. The examinations were performed by a single board-certified veterinary neurologist and were video-recorded. The videos were randomized and reviewed by a different neurologist, blinded to the previous evaluations, who scored the examinations.
RESULTS
RESULTS
Seven of 32 (22%) dogs had worse scores on their neurologic examination after receiving trazodone, manifesting as new or progressive PR deficits. Although not clinically relevant, 18.7% of the dogs had consciousness levels that changed from bright, alert, responsive to quiet, alert, responsive after trazodone administration. No other changes were observed on neurologic examination. Sedation and anxiety scores were significantly different after trazodone administration compared to before (P < .001 and P < .001, respectively).
CONCLUSIONS AND CLINICAL IMPORTANCE
CONCLUSIONS
Most dogs did not have changes on neurologic examination after trazodone administration. However, approximately 20% of dogs had new or worsening PR deficits after receiving trazodone. Ideally, trazodone should not be given before neurologic examination in dogs.
Identifiants
pubmed: 36086912
doi: 10.1111/jvim.16536
pmc: PMC9708436
doi:
Substances chimiques
Trazodone
YBK48BXK30
Anti-Anxiety Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2142-2148Subventions
Organisme : University of Wisconsin - Madison, School of Veterinary Medicine
ID : Start-up Funds
Informations de copyright
© 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
Références
J Am Vet Med Assoc. 2017 Feb 15;250(4):408-416
pubmed: 28165304
J Vet Intern Med. 2022 Nov;36(6):2142-2148
pubmed: 36086912
J Small Anim Pract. 2009 Feb;50(2):62-6
pubmed: 19037885
Vet Clin North Am Small Anim Pract. 2014 May;44(3):451-81
pubmed: 24766695
Vet J. 2009 Oct;182(1):38-43
pubmed: 18700181
J Am Vet Med Assoc. 2008 Dec 15;233(12):1902-7
pubmed: 19072606
J Am Vet Med Assoc. 2016 Dec 1;249(11):1281-1291
pubmed: 27875082
BMC Vet Res. 2017 Apr 18;13(1):110
pubmed: 28420386
Front Vet Sci. 2020 Apr 03;7:171
pubmed: 32318590
Brain Behav Immun. 2007 Nov;21(8):1009-18
pubmed: 17889502
Neuroimmunomodulation. 2009;16(5):300-17
pubmed: 19571591
Nat Rev Immunol. 2005 Mar;5(3):243-51
pubmed: 15738954
Am J Vet Res. 2013 Nov;74(11):1450-6
pubmed: 24168312
Physiol Behav. 2017 Aug 1;177:270-281
pubmed: 28501556
J Am Vet Med Assoc. 2014 Aug 1;245(3):296-301
pubmed: 25029308
Can Vet J. 2021 Sep;62(9):952-960
pubmed: 34475580
Animals (Basel). 2021 Jan 12;11(1):
pubmed: 33445559
Animals (Basel). 2014 Jun 16;4(2):331-47
pubmed: 25126422