Zranb1-mutant mice display abnormal colonic mucus production and exacerbation of DSS-induced colitis.

Animals Colitis / chemically induced Cysteine / metabolism Deubiquitinating Enzymes / metabolism Dextran Sulfate / toxicity Inflammation / pathology Intestinal Mucosa / metabolism Mice Mucins / metabolism Mucus / metabolism RNA, Messenger / genetics Serine / metabolism Ubiquitin-Specific Proteases / genetics
Colitis IBD Muc2 Organoid Ubiquitin ZRANB1

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
05 11 2022
Historique:
received: 08 08 2022
revised: 12 08 2022
accepted: 17 08 2022
pubmed: 11 9 2022
medline: 21 9 2022
entrez: 10 9 2022
Statut: ppublish

Résumé

Expression of mucin MUC2, a component of the colonic mucus layer, plays a crucial role in intestinal homeostasis. Here, we describe a new regulator of MUC2 expression, the deubiquitinase ZRANB1 (Trabid). A ZRANB1 mutation changing cysteine to serine in amino acid position 443, affects ubiquitination. To analyze ZRANB1 function in the intestine, we generated Zranb1 C443S mutant knock-in (Zranb1

Identifiants

DOI: 10.1016/j.bbrc.2022.08.046 PMID: 36087511
pubmed: 36087511
pii: S0006-291X(22)01176-7
doi: 10.1016/j.bbrc.2022.08.046
pii:
doi:

Substances chimiques

Mucins 0
RNA, Messenger 0
Serine 452VLY9402
Dextran Sulfate 9042-14-2
Deubiquitinating Enzymes EC 3.4.19.12
Ubiquitin-Specific Proteases EC 3.4.19.12
Zranb1 protein, mouse EC 3.4.99.-
Cysteine K848JZ4886

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

147-154

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Akiko Tamura (A)

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Go Ito (G)

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan; Advanced Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

Hiroki Matsuda (H)

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Yoichi Nibe-Shirakihara (Y)

Department of Pathological Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Japan.

Yuichi Hiraoka (Y)

Department of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Japan; Laboratory of Genome Editing for Biomedical Research, Medical Research Institute, Tokyo Medical and Dental University, Japan.

Sayuki Kitagawa (S)

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Yui Hiraguri (Y)

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Sayaka Nagata (S)

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Emi Aonuma (E)

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Kana Otsubo (K)

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Yasuhiro Nemoto (Y)

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Takashi Nagaishi (T)

Department of Advanced Therapeutics for G.I. Diseases, Tokyo Medical and Dental University, Tokyo, Japan.

Mamoru Watanabe (M)

Advanced Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.

Ryuichi Okamoto (R)

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Shigeru Oshima (S)

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan; Institute of Research, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: soshima.gast@tmd.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Zranb1-mutant mice display abnormal colonic...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du côlon › Colite › Zranb1-mutant mice display abnormal colonic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés soufrés › Cystéine › Zranb1-mutant mice display abnormal colonic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Enzymes de désubiquitinylation › Zranb1-mutant mice display abnormal colonic...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Dextrane › Sulfate dextran › Zranb1-mutant mice display abnormal colonic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Zranb1-mutant mice display abnormal colonic...
questionsmedicales.fr › Tissus › Membranes › Muqueuse › Muqueuse intestinale › Zranb1-mutant mice display abnormal colonic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Zranb1-mutant mice display abnormal colonic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Mucoprotéines › Mucines › Zranb1-mutant mice display abnormal colonic...
questionsmedicales.fr › Liquides et sécrétions biologiques › Sécrétions corporelles › Mucus › Zranb1-mutant mice display abnormal colonic...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Zranb1-mutant mice display abnormal colonic...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Sérine › Zranb1-mutant mice display abnormal colonic...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Endopeptidases › Ubiquitin-specific proteases › Zranb1-mutant mice display abnormal colonic...