Dengratiols E-G, three bioactive pairs of enantiomeric bibenzyl dimers from Dendrobium gratiosissimum.
Biological activity
Dendrobium gratiosissimum
Dengratiol
Enantiomeric bibenzyl dimers
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
27
05
2022
revised:
16
08
2022
accepted:
30
08
2022
pubmed:
11
9
2022
medline:
7
10
2022
entrez:
10
9
2022
Statut:
ppublish
Résumé
Three pairs of enantiomeric bibenzyl dimers, (±)-dengratiols E-G [(±)-1-3], were obtained through various chromatographic techniques including chiral HPLC, from the ethanol extract of Dendrobium gratiosissimum. Their structures were elucidated to be R-(+)-1 and S-(-)-1, R-(+)-2 and S-(-)-2, and αR, α'R-(-)-3 and αS, α'S-(+)-3 on the basis of the extensive spectroscopic data and ECD analyses, respectively. The isolated enantiomerically pure along with their racemic forms showed moderate cytotoxicity against human HCT116, U87-MG, HepG2, BGC823, and PC9 cancer cell lines (IC
Identifiants
pubmed: 36087822
pii: S0367-326X(22)00173-3
doi: 10.1016/j.fitote.2022.105295
pii:
doi:
Substances chimiques
Antiviral Agents
0
Bibenzyls
0
Plant Extracts
0
Sulfhydryl Compounds
0
Ethanol
3K9958V90M
Protein Tyrosine Phosphatase, Non-Receptor Type 1
EC 3.1.3.48
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105295Informations de copyright
Copyright © 2022. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.