Therapeutic high affinity T cell receptor targeting a KRAS
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
10 09 2022
10 09 2022
Historique:
received:
09
09
2021
accepted:
16
08
2022
entrez:
10
9
2022
pubmed:
11
9
2022
medline:
14
9
2022
Statut:
epublish
Résumé
Neoantigens derived from somatic mutations are specific to cancer cells and are ideal targets for cancer immunotherapy. KRAS is the most frequently mutated oncogene and drives the pathogenesis of several cancers. Here we show the identification and development of an affinity-enhanced T cell receptor (TCR) that recognizes a peptide derived from the most common KRAS mutant, KRAS
Identifiants
pubmed: 36088370
doi: 10.1038/s41467-022-32811-1
pii: 10.1038/s41467-022-32811-1
pmc: PMC9464187
doi:
Substances chimiques
KRAS protein, human
0
Receptors, Antigen, T-Cell
0
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5333Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M026280/1
Pays : United Kingdom
Informations de copyright
© 2022. The Author(s).
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