Genetic architecture of asthma in African American patients.
African American individuals
Asthma
GWAS
Journal
The Journal of allergy and clinical immunology
ISSN: 1097-6825
Titre abrégé: J Allergy Clin Immunol
Pays: United States
ID NLM: 1275002
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
24
12
2021
revised:
26
08
2022
accepted:
02
09
2022
pmc-release:
08
03
2024
medline:
11
4
2023
pubmed:
12
9
2022
entrez:
11
9
2022
Statut:
ppublish
Résumé
Asthma is a chronic inflammatory disorder with a strong genetic inheritance. Although more than 100 loci were reported through the genome-wide association study of European populations, the genetic underpinning of asthma in African American individuals remains largely elusive. We aimed to identify genetic loci associated with asthma in African American individuals. Three cohorts were genotyped at the Children's Hospital of Philadelphia by using the Illumina single-nucleotide polymorphism array platform. Genotype imputation was performed by using the Trans-Omics for Precision Medicine (TOPMed) reference panel, which includes whole genome sequencing data from more than 100,000 individuals. A meta-analysis of 3 Children's Hospital of Philadelphia cohorts and 10 Consortium on Asthma among African Ancestry Populations in the Americas cohorts, totaling 19,628 subjects, was conducted to identify genetic loci associated with asthma in African American individuals. Our study identified 12 loci surpassing the classical genome-wide significance threshold (5 × 10 Our findings provide candidate genetic loci for therapeutic target identification and prioritization for African populations.
Sections du résumé
BACKGROUND
Asthma is a chronic inflammatory disorder with a strong genetic inheritance. Although more than 100 loci were reported through the genome-wide association study of European populations, the genetic underpinning of asthma in African American individuals remains largely elusive.
OBJECTIVE
We aimed to identify genetic loci associated with asthma in African American individuals.
METHODS
Three cohorts were genotyped at the Children's Hospital of Philadelphia by using the Illumina single-nucleotide polymorphism array platform. Genotype imputation was performed by using the Trans-Omics for Precision Medicine (TOPMed) reference panel, which includes whole genome sequencing data from more than 100,000 individuals. A meta-analysis of 3 Children's Hospital of Philadelphia cohorts and 10 Consortium on Asthma among African Ancestry Populations in the Americas cohorts, totaling 19,628 subjects, was conducted to identify genetic loci associated with asthma in African American individuals.
RESULTS
Our study identified 12 loci surpassing the classical genome-wide significance threshold (5 × 10
CONCLUSIONS
Our findings provide candidate genetic loci for therapeutic target identification and prioritization for African populations.
Identifiants
pubmed: 36089080
pii: S0091-6749(22)01180-0
doi: 10.1016/j.jaci.2022.09.001
pmc: PMC9992439
mid: NIHMS1835164
pii:
doi:
Substances chimiques
Proteins
0
XRRA1 protein, human
0
DHRS12 protein, human
EC 1.1.1.-
Short Chain Dehydrogenase-Reductases
EC 1.1.1.-
Types de publication
Meta-Analysis
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1132-1136Subventions
Organisme : NHGRI NIH HHS
ID : U01 HG006830
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2022 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.