Association of prebiotic fiber intake with colorectal cancer risk: the PrebiotiCa study.
Colorectal cancer
Diet
Fiber
Prebiotics
Prevention
Journal
European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704
Informations de publication
Date de publication:
Feb 2023
Feb 2023
Historique:
received:
17
02
2022
accepted:
03
08
2022
pubmed:
12
9
2022
medline:
8
2
2023
entrez:
11
9
2022
Statut:
ppublish
Résumé
To evaluate the association between the intake of specific fibers with prebiotic activity, namely inulin-type fructans (ITFs), fructooligosaccharides (FOSs) and galactooligosaccharides (GOSs), and colorectal cancer risk. Within the PrebiotiCa study, we used data from a multicentric case-control study conducted in Italy and including 1953 incident, histologically confirmed, colorectal cancer patients and 4154 hospital controls. The amount of six prebiotic molecules [ITFs, nystose (FOS), kestose (FOS), 1F-β-fructofuranosylnystose (FOS), raffinose (GOS) and stachyose (GOS)] in a variety of foods was quantified via laboratory analyses. Subjects' prebiotic fiber intake was estimated by multiplying food frequency questionnaire intake by the prebiotic content of each food item. The odds ratios (OR) of colorectal cancer for quintiles of intakes were derived from logistic regression models including terms for major confounders and total energy intake. GOSs intake was inversely associated with colorectal cancer risk. The OR for the highest versus the lowest quintile of intake were 0.73 (95% confidence interval, CI 0.58-0.92) for raffinose and 0.64 (95% CI 0.53-0.77) for stachyose, with significant inverse trends across quintiles. No association was found with total ITFs and FOSs. The association with stachyose was stronger for colon (continuous OR = 0.74, 95% CI 0.66-0.83) than rectal cancer (OR = 0.89, 95% CI 0.79-1.02). Colorectal cancer risk was inversely associated with the intake of dietary GOSs, but not ITFs and FOSs.
Identifiants
pubmed: 36089645
doi: 10.1007/s00394-022-02984-y
pii: 10.1007/s00394-022-02984-y
pmc: PMC9899730
doi:
Substances chimiques
Raffinose
N5O3QU595M
Dietary Fiber
0
Fructans
0
Inulin
9005-80-5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
455-464Subventions
Organisme : Ministero della Salute
ID : GR-2016-02361123
Informations de copyright
© 2022. The Author(s).
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