Postoperative paralytic ileus following debulking surgery in ovarian cancer patients.

anastomotic leakage complications ovarian cancer paralytic ileus surgical complexity

Journal

Frontiers in surgery
ISSN: 2296-875X
Titre abrégé: Front Surg
Pays: Switzerland
ID NLM: 101645127

Informations de publication

Date de publication:
2022
Historique:
received: 23 06 2022
accepted: 08 08 2022
entrez: 12 9 2022
pubmed: 13 9 2022
medline: 13 9 2022
Statut: epublish

Résumé

This study aims to evaluate the incidence of postoperative ileus (POI) following cytoreductive surgery in epithelial ovarian cancer (EOC) patients and its impact on anastomotic leakage occurrence and postoperative complications. A total of 357 surgeries were performed on 346 ovarian cancer patients between 1/2010 and 12/2020 at our institution. The postoperative course regarding paralytic ileus, anastomotic leakage, and postoperative complications was analyzed by Fisher's exact test and through ordinal logistic regression. A total of 233 patients (65.3%) returned to normal gastrointestinal functions within 3 days after surgery. A total of 123 patients (34.5%) developed POI. There were 199 anastomoses in 165 patients and 24 leakages (12.1%). Postoperative antibiotics ( Postoperative antibiotics, an early start with laxatives, and stoma creation were associated with reduced POI rates. Patients with anastomoses showed an increased risk for POI. Severe complications, anastomotic leakages, and POI were more common in the case of intraoperative fluid balance exceeding 5,000 cc.

Identifiants

pubmed: 36090332
doi: 10.3389/fsurg.2022.976497
pmc: PMC9448895
doi:

Types de publication

Journal Article

Langues

eng

Pagination

976497

Informations de copyright

© 2022 Egger, Merker, Ralser, Marinova, Vilz, Matthaei, Hilbert and Mustea.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Lancet Gastroenterol Hepatol. 2020 Aug;5(8):729-738
pubmed: 32325012
J Clin Oncol. 2002 Mar 1;20(5):1248-59
pubmed: 11870167
J Gastrointest Surg. 2012 Jul;16(7):1379-88
pubmed: 22585532
World J Surg. 2019 Mar;43(3):659-695
pubmed: 30426190
Ann R Coll Surg Engl. 2020 Mar;102(3):194-203
pubmed: 31858809
Dis Colon Rectum. 2019 Aug;62(8):997-1004
pubmed: 30998528
Surg Oncol. 2019 Mar;28:201-207
pubmed: 30851901
J Gastrointest Surg. 2015 Sep;19(9):1684-90
pubmed: 26105552
Anticancer Res. 2019 Sep;39(9):5209-5218
pubmed: 31519635
Int J Colorectal Dis. 2022 Mar;37(3):623-630
pubmed: 34993568
Neurogastroenterol Motil. 2013 Aug;25(8):e540-9
pubmed: 23711101
Gynecol Oncol. 2018 Nov;151(2):299-305
pubmed: 30201234
Surgery. 2017 Jun;161(6):1628-1632
pubmed: 28139242
Colorectal Dis. 2016 Jan;18(1):O1-9
pubmed: 26558477
Dig Surg. 2020;37(3):192-198
pubmed: 31055568
Gynecol Oncol. 2007 Oct;107(1):99-106
pubmed: 17602726
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
J Perinat Med. 2018 Sep 25;46(7):786-790
pubmed: 29451863
Gynecol Oncol. 2020 Sep;158(3):603-607
pubmed: 32571682
Arch Gynecol Obstet. 2022 Jul;306(1):199-207
pubmed: 34958401
Gynecol Oncol. 2008 Feb;108(2):276-81
pubmed: 18063020
Arch Gynecol Obstet. 2020 Sep;302(3):707-714
pubmed: 32648028
Neurogastroenterol Motil. 2020 Aug;32(8):e13862
pubmed: 32400934
Med Oncol. 2018 May 9;35(6):95
pubmed: 29744679
Gynecol Oncol. 2013 Sep;130(3):493-8
pubmed: 23747291
Cancer. 2009 Mar 15;115(6):1234-44
pubmed: 19189349
Ann Surg Oncol. 2021 Oct;28(11):6721-6722
pubmed: 33586073
Gut. 2008 Jan;57(1):33-40
pubmed: 17591620
Ann Surg Oncol. 2022 Aug;29(8):4791-4802
pubmed: 35435561
Dig Surg. 2020;37(1):22-31
pubmed: 30636241
Front Pharmacol. 2020 Nov 24;11:583422
pubmed: 33390950
Dis Colon Rectum. 2020 Jan;63(1):68-74
pubmed: 31633601
Cancer Treat Res. 1996;82:359-74
pubmed: 8849962
BMC Surg. 2021 Feb 11;21(1):80
pubmed: 33573636
Ann Surg Oncol. 2022 Aug;29(8):4803-4804
pubmed: 35430663
Life Sci. 2021 Jun 1;274:119345
pubmed: 33713666
ANZ J Surg. 2020 Jan;90(1-2):41-47
pubmed: 31272135
Ann Coloproctol. 2021 Feb;37(1):44-50
pubmed: 32972101
Ann Surg Oncol. 2015 Apr;22(4):1061-7
pubmed: 25319579
Anesth Analg. 2018 Jun;126(6):1896-1907
pubmed: 29293183
Colorectal Dis. 2017 Jul;19(7):667-674
pubmed: 27943617
Med Sci Monit. 2018 Oct 10;24:7231-7237
pubmed: 30303179
Langenbecks Arch Surg. 2019 Feb;404(1):39-43
pubmed: 30607532
In Vivo. 2020 Nov-Dec;34(6):3361-3365
pubmed: 33144443
J Clin Epidemiol. 1994 Nov;47(11):1245-51
pubmed: 7722560

Auteurs

Eva K Egger (EK)

Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany.

Freya Merker (F)

Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany.

Damian J Ralser (DJ)

Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany.

Milka Marinova (M)

Department of Interventional and Diagnostic Radiology, University Hospital Bonn, Bonn, Germany.

Tim O Vilz (TO)

Department of Surgery, University Hospital Bonn, Bonn, Germany.

Hanno Matthaei (H)

Department of Surgery, University Hospital Bonn, Bonn, Germany.

Tobias Hilbert (T)

Department of Anesthesiology, University Hospital Bonn, Bonn, Germany.

Alexander Mustea (A)

Department of Gynecology and Gynecological Oncology, University Hospital Bonn, Bonn, Germany.

Classifications MeSH