On-demand electrochemically controlled compound release from an ultrasonically powered implant.
Journal
RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657
Informations de publication
Date de publication:
16 Aug 2022
16 Aug 2022
Historique:
received:
01
06
2022
accepted:
09
08
2022
entrez:
12
9
2022
pubmed:
13
9
2022
medline:
13
9
2022
Statut:
epublish
Résumé
On-demand drug delivery systems are promising for a wide range of therapeutic applications. When combined with wireless implants for controlled drug delivery, they can reduce overall dosage and side effects. Here, we demonstrate release of fluorescein from a novel on-demand release system for negatively charged compounds. The release system is based on a modified electroresponsive polypyrrole nanoparticulate film designed to minimize ion exchange with the stored compound - a major passive leakage mechanism. We further designed an ultrasonically powered mm-sized implant to electronically control the on-demand drug delivery system
Identifiants
pubmed: 36090393
doi: 10.1039/d2ra03422k
pii: d2ra03422k
pmc: PMC9382542
doi:
Types de publication
Journal Article
Langues
eng
Pagination
23337-23345Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts of interest to declare.
Références
J Control Release. 2006 Feb 21;110(3):531-41
pubmed: 16360955
Sci Transl Med. 2012 Feb 22;4(122):122ra21
pubmed: 22344516
IEEE Trans Biomed Circuits Syst. 2018 Oct;12(5):1100-1111
pubmed: 30235147
Nanoscale. 2016 Apr 28;8(17):9310-7
pubmed: 27088543
Nanoscale. 2016 Nov 10;8(44):18718-18725
pubmed: 27787528
J Control Release. 2014 May 10;181:1-10
pubmed: 24548479
J Pharm Pharmacol. 2007 Feb;59(2):311-5
pubmed: 17270084
Nanoscale. 2018 May 24;10(20):9773-9779
pubmed: 29767192
Nature. 1999 Jan 28;397(6717):335-8
pubmed: 9988626
Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug;2016:541-544
pubmed: 28324933
Nano Lett. 2011 Mar 9;11(3):1284-8
pubmed: 21280644
ACS Nano. 2012 Jan 24;6(1):227-33
pubmed: 22111891
IEEE Trans Biomed Eng. 2020 Jul;67(7):1821-1830
pubmed: 31634824
J Clin Endocrinol Metab. 2013 May;98(5):1845-59
pubmed: 23589524
Anal Chim Acta. 2006 May 24;568(1-2):119-25
pubmed: 17761251
J Mater Chem B. 2016 May 14;4(18):3019-3030
pubmed: 32263041
J Control Release. 2019 Sep 10;309:244-264
pubmed: 31351927
J Control Release. 2010 Aug 17;146(1):6-15
pubmed: 20359512
Sci Adv. 2021 Jan 1;7(1):
pubmed: 33523849