Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.
MAPT
MT: oligonucleotides: therapies and applications
antisense oligonucleotides
cynomolgus monkey
intrathecal
locked nucleic acids
neurodegeneration
tau
tauopathies
Journal
Molecular therapy. Nucleic acids
ISSN: 2162-2531
Titre abrégé: Mol Ther Nucleic Acids
Pays: United States
ID NLM: 101581621
Informations de publication
Date de publication:
13 Sep 2022
13 Sep 2022
Historique:
received:
20
10
2021
accepted:
31
07
2022
entrez:
12
9
2022
pubmed:
13
9
2022
medline:
13
9
2022
Statut:
epublish
Résumé
Tau is a microtubule-associated protein (
Identifiants
pubmed: 36090761
doi: 10.1016/j.omtn.2022.07.027
pii: S2162-2531(22)00196-2
pmc: PMC9424863
doi:
Types de publication
Journal Article
Langues
eng
Pagination
625-642Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
C.M.K., J.K.L., R.S., Y.B., D.D., S.E.M., and R.E.O. are employees of BMS and own stock or restricted stock units in BMS. A.E., Y. Li, Y. Lu, J.E. Meredith, J.E. Macor, M.W., V.W., K.J., M.G., J.M.B., L.H., A.F., J.P., M.B., A.B., J.E.M., C.F.A., and A.M.C. were employees of BMS when the work described was carried out. R.E.O., A.M.C., P.H.H., A.M.H., J.M.B., M.L.J., and S.E.M. are co-inventors on US Patent 10,799,523 and US patent applications US 2016/0237427, US 2018/0161356 and US 2019/0383797; and PCT patent application 2016/126995. P.H.H., R.E.O., A.M.H., and M.L.J. are co-inventors on US patent application US 2018/0023081.
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