Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders.
Brain cell types
Network analysis
Neurodegeneration
Psychiatric disorder
RNA-Seq
Transcriptome profiling
Journal
Computational and structural biotechnology journal
ISSN: 2001-0370
Titre abrégé: Comput Struct Biotechnol J
Pays: Netherlands
ID NLM: 101585369
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
04
2022
revised:
16
08
2022
accepted:
16
08
2022
entrez:
12
9
2022
pubmed:
13
9
2022
medline:
13
9
2022
Statut:
epublish
Résumé
Neurodegenerative and neuropsychiatric disorders (ND-NPs) are multifactorial, polygenic and complex behavioral phenotypes caused by brain abnormalities. Large-scale collaborative efforts have tried to identify the genetic architecture of these conditions. However, the specific and shared underlying molecular pathobiology of brain illnesses is not clear. Here, we examine transcriptome-wide characterization of eight conditions, using a total of 2,633 post-mortem brain samples from patients with Alzheimer's disease (AD), Parkinson's disease (PD), Progressive Supranuclear Palsy (PSP), Pathological Aging (PA), Autism Spectrum Disorder (ASD), Schizophrenia (Scz), Major Depressive Disorder (MDD), and Bipolar Disorder (BP)-in comparison with 2,078 brain samples from matched control subjects. Similar transcriptome alterations were observed between NDs and NPs with the top correlations obtained between Scz-BP, ASD-PD, AD-PD, and Scz-ASD. Region-specific comparisons also revealed shared transcriptome alterations in frontal and temporal lobes across NPs and NDs. Co-expression network analysis identified coordinated dysregulations of cell-type-specific modules across NDs and NPs. This study provides a transcriptomic framework to understand the molecular alterations of NPs and NDs through their shared- and specific gene expression in the brain.
Identifiants
pubmed: 36090817
doi: 10.1016/j.csbj.2022.08.037
pii: S2001-0370(22)00371-3
pmc: PMC9428860
doi:
Types de publication
Journal Article
Langues
eng
Pagination
4549-4561Informations de copyright
© 2022 Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
J Neurol Sci. 2016 Oct 15;369:242-249
pubmed: 27653898
Neuron. 2011 Jul 14;71(1):35-48
pubmed: 21745636
Nat Commun. 2019 Sep 2;10(1):3933
pubmed: 31477693
Int J Mol Sci. 2017 Jul 29;18(8):
pubmed: 28758927
Front Cell Neurosci. 2018 Aug 06;12:247
pubmed: 30127724
Neuroimage Clin. 2017 Sep 06;16:575-585
pubmed: 28971008
Expert Rev Neurother. 2010 Jul;10(7):1131-41
pubmed: 20586693
PLoS One. 2012;7(4):e36351
pubmed: 22558445
Brain Pathol. 2007 Jan;17(1):74-82
pubmed: 17493041
Gene. 2017 Mar 30;606:17-24
pubmed: 28042091
Nat Neurosci. 2015 Aug;18(8):1168-74
pubmed: 26167905
Neurorehabil Neural Repair. 2016 Nov;30(10):963-971
pubmed: 27221042
Front Aging Neurosci. 2019 Aug 30;11:233
pubmed: 31543810
Arzneimittelforschung. 1992 Feb;42(2A):265-8
pubmed: 1350197
Sci Rep. 2018 Jun 11;8(1):8868
pubmed: 29892006
Cold Spring Harb Perspect Biol. 2015 Apr 15;7(6):
pubmed: 25877220
PLoS One. 2016 Dec 16;11(12):e0166944
pubmed: 27992436
Nat Rev Neurosci. 2017 Jan 20;18(2):101-113
pubmed: 28104909
Prog Neurobiol. 2017 Feb - Mar;149-150:1-20
pubmed: 28143732
Nat Rev Genet. 2015 Aug;16(8):441-58
pubmed: 26149713
Mol Psychiatry. 2006 Jul;11(7):615, 663-79
pubmed: 16636682
Cell. 2019 Dec 12;179(7):1469-1482.e11
pubmed: 31835028
Source Code Biol Med. 2012 May 28;7(1):6
pubmed: 22640879
Nature. 2021 Nov;599(7886):650-656
pubmed: 34732887
Database (Oxford). 2019 Jan 1;2019:
pubmed: 30951143
Neurochem Res. 2008 Dec;33(12):2502-9
pubmed: 18998208
Redox Biol. 2020 Jul;34:101558
pubmed: 32447261
Neurology. 2011 Apr 12;76(15):1344-52
pubmed: 21482951
Front Neurol. 2011 Jul 11;2:42
pubmed: 21808630
Curr Neuropharmacol. 2018;16(5):508-518
pubmed: 28730967
Neurobiol Aging. 2017 Dec;60:104-115
pubmed: 28941726
PLoS One. 2014 Apr 28;9(4):e95875
pubmed: 24776767
Nucleic Acids Res. 2010 Sep;38(17):e169
pubmed: 20660011
Parkinsonism Relat Disord. 2020 Apr;73:105-116
pubmed: 32487421
Bioinformatics. 2016 Jan 15;32(2):292-4
pubmed: 26428292
Bioinformatics. 2013 Mar 1;29(5):614-21
pubmed: 23329413
JAMA Psychiatry. 2013 Jan;70(1):49-58
pubmed: 23404112
Nat Commun. 2016 Mar 31;7:11173
pubmed: 27029645
J Psychiatr Res. 2020 Nov;130:167-176
pubmed: 32823050
Nat Neurosci. 2020 Feb;23(2):167-171
pubmed: 31873194
Front Neurol. 2019 Oct 03;10:1059
pubmed: 31632342
Neuroimage. 2014 Nov 15;102 Pt 2:657-65
pubmed: 25173418
Nat Neurosci. 2006 Feb;9(2):157-8
pubmed: 16439979
Front Aging Neurosci. 2019 Mar 19;11:59
pubmed: 30941031
Neurobiol Aging. 2015 Jan;36(1):241-8
pubmed: 25212465
Genome Med. 2017 Jul 28;9(1):72
pubmed: 28754123
Mol Psychiatry. 2017 Mar;22(3):441-449
pubmed: 27350034
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
Pac Symp Biocomput. 2016;22:94-104
pubmed: 27896965
Cell Stress Chaperones. 2020 Jul;25(4):655-665
pubmed: 32301006
BMC Med Genomics. 2016 Jan 21;9:5
pubmed: 26793951
Biol Psychiatry. 2006 Sep 15;60(6):650-8
pubmed: 16997002
Nat Med. 2017 Sep;23(9):1102-1111
pubmed: 28825715
Front Neuroendocrinol. 2019 Jan;52:156-164
pubmed: 30481522
Front Pharmacol. 2019 Sep 27;10:1114
pubmed: 31611796
Neurosci Biobehav Rev. 2018 Oct;93:57-70
pubmed: 29944960
Glia. 2021 Jul;69(7):1799-1815
pubmed: 33710690
Neuron Glia Biol. 2011 May;7(2-4):205-13
pubmed: 22874006
Alzheimers Dement. 2016 Mar;12(3):292-323
pubmed: 27012484
J Neurodev Disord. 2015;7(1):29
pubmed: 26322138
Brain Pathol. 2013 May;23(3):263-73
pubmed: 22994884
Front Aging Neurosci. 2017 May 29;9:166
pubmed: 28611656
Hum Mol Genet. 2005 Jan 15;14(2):241-53
pubmed: 15563509
Bioinformatics. 2014 Oct;30(19):2811-2
pubmed: 24930139
Mol Cell. 2020 Mar 19;77(6):1176-1192.e16
pubmed: 31999954
Nat Neurosci. 2018 Aug;21(8):1117-1125
pubmed: 30050107
Mol Syst Biol. 2009;5:291
pubmed: 19638972
Transl Psychiatry. 2017 May 9;7(5):e1126
pubmed: 28485729
Science. 2018 Feb 9;359(6376):693-697
pubmed: 29439242
Nat Neurosci. 2014 Jun;17(6):782-90
pubmed: 24866044
Neuroscience. 2021 Dec 15;479:192-205
pubmed: 34748859
Cell. 2014 May 22;157(5):1216-29
pubmed: 24855953
Transl Psychiatry. 2017 Aug 15;7(8):e1203
pubmed: 28809853
Sci Rep. 2020 Apr 28;10(1):7118
pubmed: 32346016
Neuron. 2016 Jan 6;89(1):37-53
pubmed: 26687838
Mol Aspects Med. 2019 Dec;70:127-140
pubmed: 31319085
Brain Behav Immun. 2019 Jul;79:75-90
pubmed: 31029798
BMC Bioinformatics. 2011 Aug 04;12:323
pubmed: 21816040
RNA. 2014 Jul;20(7):1103-11
pubmed: 24847104
Brain Pathol. 1990 Sep;1(1):2-5
pubmed: 1669689
Nat Neurosci. 2019 Oct;22(10):1617-1623
pubmed: 31551603
Cell Death Differ. 2015 Dec;22(12):2034-45
pubmed: 26470727
World J Radiol. 2017 Oct 28;9(10):371-388
pubmed: 29104740
Aging Dis. 2019 Jun 01;10(3):664-675
pubmed: 31165009
Life Sci Alliance. 2019 Dec 2;2(6):
pubmed: 31792059
Mol Psychiatry. 2017 May;22(5):760-773
pubmed: 27528462
Sci Data. 2018 Sep 11;5:180185
pubmed: 30204156
Int J Geriatr Psychiatry. 2018 May;33(5):703-709
pubmed: 29280514
Front Pharmacol. 2020 Jun 16;11:886
pubmed: 32612529
PLoS Biol. 2016 Sep 29;14(9):e1002558
pubmed: 27685936
Schizophr Bull. 2012 Sep;38(5):1040-9
pubmed: 21536784
Prog Neuropsychopharmacol Biol Psychiatry. 2001 May;25(4):691-707
pubmed: 11383973
World Psychiatry. 2020 Feb;19(1):15-33
pubmed: 31922684
Nat Commun. 2021 May 18;12(1):2909
pubmed: 34006833
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Neuroimage Clin. 2017 Jun 01;15:494-501
pubmed: 28649492
Lancet. 2013 Apr 20;381(9875):1371-1379
pubmed: 23453885
J Neurosci. 2014 Jan 22;34(4):1420-31
pubmed: 24453331
Alzheimers Res Ther. 2014 May 06;6(3):24
pubmed: 25031637
Nat Commun. 2019 Dec 4;10(1):5535
pubmed: 31797870
Nature. 2009 Aug 6;460(7256):748-52
pubmed: 19571811
Nat Biotechnol. 2017 Apr 11;35(4):316-319
pubmed: 28398311
Sci Data. 2016 Oct 11;3:160089
pubmed: 27727239
Mol Syst Biol. 2014 Dec 30;10:774
pubmed: 25549968
Commun Biol. 2021 Jan 8;4(1):61
pubmed: 33420340
Science. 2018 Dec 14;362(6420):
pubmed: 30545854
Neurobiol Aging. 2017 Jan;49:204-213
pubmed: 27836336
Nat Rev Neurosci. 2012 Apr 18;13(5):293-307
pubmed: 22510887
Nat Med. 2017 Sep 8;23(9):1018-1027
pubmed: 28886007
Transl Neurodegener. 2013 Aug 08;2(1):17
pubmed: 23925007
Science. 2015 May 1;348(6234):499-500
pubmed: 25931539
BMC Bioinformatics. 2008 Dec 29;9:559
pubmed: 19114008
Nat Rev Neurosci. 2012 Jan 05;13(2):77-93
pubmed: 22218207
Int Rev Neurobiol. 2013;112:155-77
pubmed: 24295621
Genome Med. 2018 Jan 31;10(1):9
pubmed: 29386063
Nat Genet. 2019 Jul;51(7):1193
pubmed: 31160808
Schizophr Res. 2012 Aug;139(1-3):1-6
pubmed: 22647883
Transl Psychiatry. 2020 Aug 14;10(1):286
pubmed: 32796821
Neurobiol Aging. 2006 Oct;27(10):1435-9
pubmed: 16137793
Mol Psychiatry. 2014 Nov;19(11):1179-85
pubmed: 24393808
Front Hum Neurosci. 2016 Nov 08;10:566
pubmed: 27877121
Nat Rev Neurosci. 2015 Jun;16(6):345-57
pubmed: 25991442
Cells. 2020 Jul 14;9(7):
pubmed: 32674367
Neurobiol Aging. 2017 May;53:36-47
pubmed: 28208064
Brain. 2016 Mar;139(Pt 3):922-36
pubmed: 26813969