Mesenchymal stem cell therapy: A review of clinical trials for multiple sclerosis.
Hematopoietic stem cells
Mesenchymal stem cells
Multiple sclerosis
Regenerative medicine
Stem cell therapy
Journal
Regenerative therapy
ISSN: 2352-3204
Titre abrégé: Regen Ther
Pays: Netherlands
ID NLM: 101709085
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
27
05
2022
revised:
02
07
2022
accepted:
15
07
2022
entrez:
12
9
2022
pubmed:
13
9
2022
medline:
13
9
2022
Statut:
epublish
Résumé
Multiple sclerosis (MS) is a disease of the central nervous system (CNS) that is the result of the body's own immune cells being auto-reactive to the myelin regions of the body as if these regions were foreign antigens. This demyelination process is damaging to the electrical conductivity of neurons. The current medicines are only capable of fighting off the symptoms of the disease, but not the disease itself. Specialized stem cells, known as mesenchymal stem cells (MSCs), seem to be the candidate therapy to get rid of MS. MSCs can be isolated from multiple sources of the person's body, and even from the umbilical cord (UC) and placenta of a donor. These cells have anti-inflammatory effects so they can target the overactivity and self-antigen attacks by T cells and macrophages; this immune system overactivity is characteristic of MS. MSCs show the ability to locate into brain lesions when injected and thus can compensate for the loss of the brain function by differentiating into neuronal precursor cells and glial cells. The author has listed tables of clinical trials that have utilized MSCs from different sources, along with the years and the phase of study completed for each trial. The consensus is that these cells work on inhibiting CD4
Identifiants
pubmed: 36092509
doi: 10.1016/j.reth.2022.07.003
pii: S2352-3204(22)00066-9
pmc: PMC9420954
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
201-209Informations de copyright
© 2022 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.
Déclaration de conflit d'intérêts
The author has no conflict of interest to declare.
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