Subunit Flexibility of Multimeric von Willebrand Factor/Factor VIII Complexes.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
06 Sep 2022
06 Sep 2022
Historique:
received:
31
05
2022
accepted:
10
08
2022
entrez:
12
9
2022
pubmed:
13
9
2022
medline:
13
9
2022
Statut:
epublish
Résumé
Von Willebrand factor (VWF) is a plasma glycoprotein that participates in platelet adhesion and aggregation and serves as a carrier for blood coagulation factor VIII (fVIII). Plasma VWF consists of a population of multimers that range in molecular weight from ∼ 0.55 MDa to greater than 10 MDa. The VWF multimer consists of a variable number of concatenated disulfide-linked ∼275 kDa subunits. We fractionated plasma-derived human VWF/fVIII complexes by size-exclusion chromatography at a pH of 7.4 and subjected them to analysis by sodium dodecyl sulfate agarose gel electrophoresis, sedimentation velocity analytical ultracentrifugation (SV AUC), dynamic light scattering (DLS), and multi-angle light scattering (MALS). Weight-average molecular weights,
Identifiants
pubmed: 36092565
doi: 10.1021/acsomega.2c03389
pmc: PMC9453814
doi:
Types de publication
Journal Article
Langues
eng
Pagination
31183-31196Informations de copyright
© 2022 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Blood. 2002 Jan 15;99(2):450-6
pubmed: 11781224
Biochemistry. 1986 Jun 3;25(11):3171-84
pubmed: 3524673
Curr Protoc Protein Sci. 2013 Feb;Chapter 20:Unit20.12
pubmed: 23377850
Anal Chem. 2003 Aug 15;75(16):4279-91
pubmed: 14632147
Anal Chem. 2020 Aug 18;92(16):10863-10871
pubmed: 32678579
Blood. 2014 Aug 28;124(9):1412-25
pubmed: 24928861
PLoS One. 2015 May 21;10(5):e0126420
pubmed: 25997164
J Biol Chem. 1997 Oct 3;272(40):25162-7
pubmed: 9312128
Cell. 2020 Oct 29;183(3):717-729.e16
pubmed: 33031746
J Clin Invest. 1980 Jun;65(6):1318-25
pubmed: 6773982
Biophys Rev. 2016 Dec;8(4):409-427
pubmed: 28510011
Biophys J. 2000 Mar;78(3):1606-19
pubmed: 10692345
Annu Rev Biochem. 1998;67:395-424
pubmed: 9759493
Bio Protoc. 2021 Oct 20;11(20):e4195
pubmed: 34761067
J Clin Invest. 1985 Oct;76(4):1491-500
pubmed: 2932468
EMBO J. 2011 Aug 19;30(19):4098-111
pubmed: 21857647
J Mol Biol. 2020 Apr 17;432(9):2930-2948
pubmed: 31877325
N Engl J Med. 1982 Dec 2;307(23):1432-5
pubmed: 6813740
J Thromb Haemost. 2011 Jul;9 Suppl 1:130-43
pubmed: 21781248
J Phys Colloid Chem. 1947 Jan;51(1):18-32
pubmed: 20286386
Blood. 2019 Apr 4;133(14):1523-1533
pubmed: 30642920
Protein Sci. 2002 Sep;11(9):2067-79
pubmed: 12192063
Biophys J. 2010 May 19;98(9):L35-7
pubmed: 20441731
Anal Biochem. 2014 Aug 1;458:37-9
pubmed: 24799348
Biotechnol Genet Eng Rev. 2014 Oct;30(1-2):142-57
pubmed: 25686159
J Biol Chem. 2004 Feb 20;279(8):6546-52
pubmed: 14660593
Biomacromolecules. 2007 Aug;8(8):2464-75
pubmed: 17645309
Nat Commun. 2017 Aug 23;8(1):324
pubmed: 28831047
J Cell Biol. 1982 Nov;95(2 Pt 1):632-40
pubmed: 6815213
Methods Enzymol. 2004;384:185-212
pubmed: 15081688
J Biol Chem. 1998 Apr 24;273(17):10396-401
pubmed: 9553097
Haemophilia. 2013 Jan;19 Suppl 1:8-11
pubmed: 23278994
Appl Opt. 2001 Aug 20;40(24):4087-91
pubmed: 18360445
Nature. 2001 Oct 4;413(6855):488-94
pubmed: 11586351
Methods Cell Biol. 2008;84:143-79
pubmed: 17964931
Protein Sci. 2010 Jan;19(1):94-8
pubmed: 19916166
Stat Med. 1990 Dec;9(12):1463-73
pubmed: 2281234
Clin Chem. 2013 Apr;59(4):684-91
pubmed: 23340442
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12391-2
pubmed: 11070072
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9226-31
pubmed: 19470641
J Biol Chem. 1985 Jul 15;260(14):8559-63
pubmed: 3874208
Biochemistry. 1986 Jun 3;25(11):3146-55
pubmed: 3015199
J Thromb Haemost. 2009 Jul;7 Suppl 1:24-7
pubmed: 19630761
Protein Sci. 1995 Nov;4(11):2411-23
pubmed: 8563639
Biophys J. 2011 May 4;100(9):2309-17
pubmed: 21539801
Anal Biochem. 2003 Sep 1;320(1):104-24
pubmed: 12895474
Methods Enzymol. 2015;562:109-33
pubmed: 26412649
J Biol Chem. 2021 Jan-Jun;296:100420
pubmed: 33600794