The FDA-approved drug Auranofin has a dual inhibitory effect on SARS-CoV-2 entry and NF-κB signaling.
Biochemistry
Chemistry
Medical biochemistry
Molecular biology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
21 Oct 2022
21 Oct 2022
Historique:
received:
12
04
2022
revised:
21
07
2022
accepted:
30
08
2022
pubmed:
13
9
2022
medline:
13
9
2022
entrez:
12
9
2022
Statut:
ppublish
Résumé
Patients with severe COVID-19 show an altered immune response that fails to control the viral spread and suffer from exacerbated inflammatory response, which eventually can lead to death. A major challenge is to develop an effective treatment for COVID-19. NF-κB is a major player in innate immunity and inflammatory process. By a high-throughput screening approach, we identified FDA-approved compounds that inhibit the NF-κB pathway and thus dampen inflammation
Identifiants
pubmed: 36093378
doi: 10.1016/j.isci.2022.105066
pii: S2589-0042(22)01338-4
pmc: PMC9439859
doi:
Types de publication
Journal Article
Langues
eng
Pagination
105066Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors have no competing interests.
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