A TRPM7 mutation linked to familial trigeminal neuralgia: Omega current and hyperexcitability of trigeminal ganglion neurons.
TRP channels
gating current
human mutations
trigeminal neuralgia
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
20 09 2022
20 09 2022
Historique:
entrez:
12
9
2022
pubmed:
13
9
2022
medline:
15
9
2022
Statut:
ppublish
Résumé
Trigeminal neuralgia (TN) is a unique pain disorder characterized by intense paroxysmal facial pain within areas innervated by the trigeminal nerve. Although most cases of TN are sporadic, familial clusters of TN suggest that genetic factors may contribute to this disorder. Whole-exome sequencing in patients with TN reporting positive family history demonstrated a spectrum of variants of ion channels including TRP channels. Here, we used patch-clamp analysis and Ca
Identifiants
pubmed: 36095216
doi: 10.1073/pnas.2119630119
pmc: PMC9499596
doi:
Substances chimiques
TRPM Cation Channels
0
Protein Serine-Threonine Kinases
EC 2.7.11.1
TRPM7 protein, human
EC 2.7.11.1
Alanine
OF5P57N2ZX
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2119630119Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
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