Progesterone withdrawal and parturition.
Parturition
Pregnancy
Progesterone
Progesterone withdrawal
Journal
The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
23
06
2021
revised:
30
08
2022
accepted:
07
09
2022
medline:
23
10
2023
pubmed:
13
9
2022
entrez:
12
9
2022
Statut:
ppublish
Résumé
The steroid hormone progesterone (P4), acting via the nuclear P4 receptors (PRs) in uterine cells, is essential for the establishment and maintenance of pregnancy. P4/PR signaling maintains pregnancy by promoting uterine quiescence and blocking the contractions of labor. Withdrawal of the P4/PR block to labor induces parturition. The success of pregnancy requires the timely birth of a mature neonate to a healthy mother, and to this end, the mechanism by which the P4/PR block is withdrawn, and how that process is physiologically controlled is critical. This review examines current understanding of cell and molecular biology of P4/PR withdrawal in the control of parturition.
Identifiants
pubmed: 36096351
pii: S0960-0760(22)00128-5
doi: 10.1016/j.jsbmb.2022.106177
pii:
doi:
Substances chimiques
Progesterone
4G7DS2Q64Y
Receptors, Progesterone
0
Types de publication
Review
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106177Informations de copyright
Copyright © 2022. Published by Elsevier Ltd.