Prevalence of haplotype DQ2/DQ8 and celiac disease in children with type 1 diabetes.
Celiac disease
Diabetes type 1
Haplotype HLA-DQ2/DQ8
Journal
Diabetology & metabolic syndrome
ISSN: 1758-5996
Titre abrégé: Diabetol Metab Syndr
Pays: England
ID NLM: 101488958
Informations de publication
Date de publication:
12 Sep 2022
12 Sep 2022
Historique:
received:
10
06
2022
accepted:
17
08
2022
entrez:
12
9
2022
pubmed:
13
9
2022
medline:
13
9
2022
Statut:
epublish
Résumé
Type 1 diabetes (T1D) and celiac disease (CD) coexist very often. Identification of the human leukocyte antigen (HLA) DQ2/DQ8 can confirm the genetic predisposition to CD. Negative result of this test allows to exclude CD with a high probability. It was suggested that in individuals with higher risk of CD, including T1D patients, the implementation of genetic testing should reduce the number of patients requiring systematic immunological screening. The aim of this study was to analyze the prevalence of different haplotypes predisposing to CD in children and adolescents with previously diagnosed T1D. A retrospective analysis was performed on 166 T1D children (91 girls) in whom HLA DQ2/DQ8 alleles were tested. In 9.6% CD was also diagnosed. In 12.7% both HLA DQ2/DQ8 were negative. In 87.3% patients HLA DQ2 and/or DQ8 was positive, including 27.7% patients with both haplotypes DQ2.5 and DQ8 positive. In all CD patients the disease predisposing alleles were positive, while none of the HLA DQ2/DQ8 negative children were diagnosed with CD. The prevalence of HLA DQ2.5 and the HLA DQ2.5 / HLA DQ8 configuration is higher in patients with T1D, and CD compared to children with T1D alone. The combination of HLA DQ2 and HLA DQ8 most significantly increases the risk of developing CD. The group of HLA DQ2/DQ8 negative patients with improbable CD diagnosis, is relatively small. Most of T1D patients HLA DQ2/DQ8 positive need further regular antibody assessment. In patients with T1D, who are at high risk of developing CD, genetic testing may be considered to select those who require further systematic serological evaluation. Due to its retrospective nature, the study was not registered in the database of clinical trials and the Clinical trial registration number is not available.
Identifiants
pubmed: 36096955
doi: 10.1186/s13098-022-00897-8
pii: 10.1186/s13098-022-00897-8
pmc: PMC9465882
doi:
Types de publication
Journal Article
Langues
eng
Pagination
128Informations de copyright
© 2022. The Author(s).
Références
Nutr Metab Cardiovasc Dis. 2014 Apr;24(4):378-83
pubmed: 24393392
Pediatr Diabetes. 2012 Dec;13(8):597-606
pubmed: 22564209
Hum Immunol. 2009 Jan;70(1):55-9
pubmed: 19027045
Gastroenterology. 2000 Jul;119(1):234-42
pubmed: 10889174
J Pediatr Gastroenterol Nutr. 2012 Jan;54(1):136-60
pubmed: 22197856
Curr Diab Rep. 2014 Aug;14(8):517
pubmed: 24952108
N Engl J Med. 1965 Mar 4;272:448-56
pubmed: 14242522
Hum Immunol. 2003 Apr;64(4):469-77
pubmed: 12651074
Intest Res. 2018 Apr;16(2):288-292
pubmed: 29743842
Lancet. 2018 Jan 6;391(10115):70-81
pubmed: 28760445
Front Endocrinol (Lausanne). 2020 Aug 06;11:476
pubmed: 32849272
J Pediatr Gastroenterol Nutr. 2020 Jan;70(1):141-156
pubmed: 31568151
Hum Immunol. 2020 Feb - Mar;81(2-3):59-64
pubmed: 32005535
Acta Diabetol. 2015 Jun;52(3):483-8
pubmed: 25381194
Tissue Antigens. 1997 Jan;49(1):29-34
pubmed: 9027962
BMC Med. 2019 Jul 23;17(1):142
pubmed: 31331324
Endocrinol Metab Clin North Am. 2002 Jun;31(2):339-52
pubmed: 12092454
Clin Genet. 2011 Sep;80(3):203-313
pubmed: 21595655
Diabetes Care. 2004 Jun;27(6):1294-8
pubmed: 15161778
Front Nutr. 2020 Feb 07;7:6
pubmed: 32118025
Diabetes Care. 2006 Apr;29(4):858-63
pubmed: 16567828
Gut. 2007 Aug;56(8):1054-9
pubmed: 17344279
Acta Biomed. 2018 Dec 17;89(9-S):17-21
pubmed: 30561391
BMC Gastroenterol. 2015 Dec 21;15:181
pubmed: 26692164
Nat Immunol. 2009 Oct;10(10):1096-101
pubmed: 19718029
Nat Genet. 2010 Apr;42(4):295-302
pubmed: 20190752
Maedica (Bucur). 2017 Jun;12(2):136-142
pubmed: 29090036
Prz Gastroenterol. 2014;9(1):11-7
pubmed: 24868293
J Biomed Sci. 2012 Oct 11;19:88
pubmed: 23050549
Hum Immunol. 2011 Feb;72(2):179-82
pubmed: 21075156
World J Gastrointest Pathophysiol. 2017 May 15;8(2):27-38
pubmed: 28573065
Rev Gastroenterol Mex. 2015 Apr-Jun;80(2):135-43
pubmed: 26088570
Pediatr Diabetes. 2011 Jun;12(4 Pt 1):322-5
pubmed: 21615651
PLoS Genet. 2011 Feb;7(2):e1002004
pubmed: 21383967
PLoS One. 2008 May 28;3(5):e2270
pubmed: 18509540
PLoS One. 2015 Mar 04;10(3):e0118618
pubmed: 25738288
Diabetes Care. 2011 Oct;34(10):2158-63
pubmed: 21911773
Pediatrics. 2002 May;109(5):833-8
pubmed: 11986443
Cells. 2019 Jul 19;8(7):
pubmed: 31331105
Pediatr Diabetes. 2018 Oct;19 Suppl 27:275-286
pubmed: 30066458
QJM. 1996 Oct;89(10):737-43
pubmed: 8944229
Hum Pathol. 2011 Aug;42(8):1112-6
pubmed: 21292306
J Diabetes. 2021 Jun;13(6):448-457
pubmed: 33118261
Clin Gastroenterol Hepatol. 2004 Oct;2(10):888-94
pubmed: 15476152
Gastroenterology. 2005 Apr;128(4 Suppl 1):S47-51
pubmed: 15825126
Nat Rev Endocrinol. 2011 Nov 08;8(1):7-8
pubmed: 22064502
Arch Immunol Ther Exp (Warsz). 2018 Dec;66(6):423-430
pubmed: 30167716
Diabetol Metab Syndr. 2016 Jul 29;8:51
pubmed: 27478507
World J Diabetes. 2019 Mar 15;10(3):189-199
pubmed: 30891154
Ital J Pediatr. 2012 Mar 26;38:10
pubmed: 22449104
Gastroenterology. 2012 Mar;142(3):552-61
pubmed: 22108197
Am J Gastroenterol. 2008 Jan;103(1):190-5
pubmed: 18184122
Diabetes Care. 2006 Nov;29(11):2452-6
pubmed: 17065683
Diabetes. 2008 Apr;57(4):1084-92
pubmed: 18252895